Papers by Maryam Niknejadi
International Journal of Fertility & Sterility, 2010
Bookmarks Related papers MentionsView impact
Journal of Ovarian Research
Background Ovarian reserve is a crucial indicator of a woman’s fertility potential, which is dete... more Background Ovarian reserve is a crucial indicator of a woman’s fertility potential, which is determined by the quality and quantity of antral follicles and oocytes. However, certain factors such as endometriosis, pelvic inflammatory disease, myoma, and the natural process of aging can lead to a poor ovarian response to stimulation, reducing a woman’s chances of conceiving. Objective To evaluate the effect of uterus congenital anomalies and uterine leiomyoma are associated on ovarian reserve. Methods The present cross-sectional study was performed on 321 infertile women in three groups consisted of 97 infertile women with intramural uterine leiomyoma and 81 infertile women with uterine anomalies and 143 infertile women without uterine anomalies and uterine leiomyoma during 2017–2019 in Royan Center. Sampling method was continuous and available. Data collection tool in this study was a questionnaire which was in two parts of individual variables and the second part was related to ultr...
Bookmarks Related papers MentionsView impact
Connective Tissue Research
Bookmarks Related papers MentionsView impact
Archives of Iranian Medicine, Jun 1, 2015
Bookmarks Related papers MentionsView impact
Poster: "ECR 2015 / C-0851 / Hysterosalpingography findings among a large sample of infertil... more Poster: "ECR 2015 / C-0851 / Hysterosalpingography findings among a large sample of infertile women: A cross sectional study" by: "M. Niknejadi, A. Pooyan, M. Javam, F. Niknejad; Tehran/IR"
Bookmarks Related papers MentionsView impact
Iranian Journal of Radiology, 2010
In this case report, we present a dizygotic twin pregnancy with two different major anomalies one... more In this case report, we present a dizygotic twin pregnancy with two different major anomalies one of which was a fetus with multiple congenital anomalies consisting of alobar holoprosencephaly, cleft lip and palate, enlarged echogenic kidneys and clubfoot. The other fetus with early asymmetrical growth restriction and sandal gap sign suggesting Down syndrome which was confirmed after birth.
Bookmarks Related papers MentionsView impact
Objective: Perianal fistulas in Crohn's disease (CD) are the main challenges in inflammat... more Objective: Perianal fistulas in Crohn's disease (CD) are the main challenges in inflammatory bowel diseases (IBDs). Some of the fistulas are refractory to any therapeutic strategy. The aim of this study was to evaluate the therapeutic effects of mesenchymal stromal cells (MSCs) as a novel promising modality for the treatment of fistulizing CD. Materials and Methods: This case series clinical interventional study was conducted from 2014 to 2017 at Shariati Hospital, an IBD referral center in Tehran, Iran. Refractory adult patients with CD who had draining perianal fistulas were enrolled in this study. All patients were examined by a colorectal surgeon and the fistula imaging studies were performed by pelvic magnetic resonance imaging (MRI). After autologous bone marrow (BM) aspiration and MSCs isolation, the cells were cultured and passaged under current good manufacturing practice (cGMP) conditions. Four intra-fistula injections of cells, each containing 40×10 6 MSCs suspended in fibrin glue, were administered by an expert surgeon every 4 weeks. Procedure safety, feasibility and closure of the perianal fistulas at week 24 were assessed. Clinical examination and MRI findings were considered as the primary end points. Results: In total, 5 patients (2 males and 3 females) were enrolled in this study. No adverse events were observed during the six-month follow-up in these patients. Both the Crohn's Disease Activity Index (CDAI) and Perianal Disease Activity Index (PDAI) scores decreased in all patients after cell injections and one patient achieved complete remission with closure of fistulas, discontinuation of fistula discharge, and closure of the external opening. Conclusion: Local injection of MSCs combined with fibrin glue is potentially a safe and effective therapeutic approach for complex perianal fistulas in patients with CD.
Bookmarks Related papers MentionsView impact
International Journal of Fertility and Sterility, 2010
Pregnancy implantation within the scar of a previous cesarean delivery is one of the rarest locat... more Pregnancy implantation within the scar of a previous cesarean delivery is one of the rarest locations for an ectopic pregnancy. Early diagnosis of this condition with the use of ultrasound imaging allows for preserving the uterus and subsequent fertility. However, a delay in either diagnosis or treatment can lead to uterine rupture, hysterectomy and significant maternal morbidity. With increasing incidence of cesarean sections (CS) worldwide and more liberal use of transvaginal sonography (TVS) in early pregnancy, more cases of cesarean scar pregnancy (CSP) are diagnosed. Thus every woman with a previous CS presenting to the early pregnancy unit should have a routine check for the cesarean scar appearance. We present the case of a 34 year-old multigravid woman who was found to have an ectopic pregnancy in a cesarean scar at six weeks gestation, with significantly elevated beta-human chorionic gonadotrophin (Beta-hCG) level.
Bookmarks Related papers MentionsView impact
International Journal of Fertility and Sterility, 2010
Background To evaluate the diagnostic accuracy of transvaginal sonography (TVS) in infertile pati... more Background To evaluate the diagnostic accuracy of transvaginal sonography (TVS) in infertile patients and compare its results with hysteroscopy as the gold standard. Materials and methods A total of 679 infertile women who underwent both TVS and diagnostic hysteroscopy were retrospectively investigated. TVS was performed in the mid-follicular phase (days 5-8) of their cycles. Sensitivity specificity and positive and negative predictive values were calculated for TVS. Results Hysteroscopy diagnosed endometrial polyps in 197 out of 679 cases (24.5%). TVS confirmed the hysteroscopy findings in 174 of 197 (88.3%) cases. The sensitivity specificity and positive and negative predictive values of TVS compared to hysteroscopy in the detection of endometrial polyps were 88.3% 91.9% 81.6% and 90.8% respectively. Conclusion TVS is both a cost-effective and non-invasive method for the diagnosis of intrauterine lesions such as polyps. When used in conjunction with a saline infusion it can be a p...
Bookmarks Related papers MentionsView impact
Archives of Iranian medicine, 2015
BACKGROUND Osteoarthritis (OA) is a debilitating disease that typically affects a large number of... more BACKGROUND Osteoarthritis (OA) is a debilitating disease that typically affects a large number of the middle-aged and elderly population. Current treatment strategies have had limited success in these patients. This study aims to investigate the safety of treatment with autologous bone marrow (BM)-derived mesenchymal stem cells (MSCs) transplanted in patients with OA of the knee, ankle, or hip. METHODS We enrolled 18 patients with different joint involvements (knee, ankle, or hip OA) and one was lost to follow-up. BM samples were taken from the patients, after which BM-derived MSCs were isolated and cultured. Each patient received one MSC injection. Patients were followed with clinical examinations, MRI and laboratory tests at 2, 6, 12, and 30 months post-transplantation. RESULTS We observed no severe adverse events such as pulmonary embolism, death, or systemic complications. A limited number of patients had very minor localized adverse effects such as rash and erythema. There were...
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Pregnancy implantation within the scar of a previous cesarean delivery is one of the rarest locat... more Pregnancy implantation within the scar of a previous cesarean delivery is one of the rarest locations for an ectopic pregnancy. Early diagnosis of this condition with the use of ultrasound imaging allows for preserving the uterus and subsequent fertility. However, a delay in either diagnosis or treatment can lead to uterine rupture, hysterectomy and significant maternal morbidity. With increasing incidence of cesarean sections (CS) worldwide and more liberal use of transvaginal sonography (TVS) in early pregnancy, more cases of cesarean scar pregnancy (CSP) are diagnosed. Thus every woman with a previous CS presenting to the early pregnancy unit should have a routine check for the cesarean scar appearance. We present the case of a 34 year-old multigravid woman who was found to have an ectopic pregnancy in a cesarean scar at six weeks gestation, with significantly elevated beta-human chorionic gonadotrophin (Beta-hCG) level.
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Iranian Journal of Reproductive Medicine, 2013
Background: Assessment of uterine abnormalities is a core part in infertility evaluation. Objecti... more Background: Assessment of uterine abnormalities is a core part in infertility evaluation. Objective: The aim of this study was to evaluate the sensitivity and specificity of three-dimensional hysterosonography (3-DHS) in the diagnosis of uterine abnormalities in infertile women. Materials and Methods: The infertile women who visited Royan Institute and referred to 3-DHS consecutively, prior to in vitro fertilization, from 2010-2011 included in this cross-sectional study. For patients who underwent hysteroscopy in addition to 3-DHS (214/977), the verification bias adjusted sensitivity and specificity of 3-DHS which were calculated by global sensitivity analysis method. Hysteroscopy was used as the gold standard for diagnosis of uterine abnormalities. Histological diagnosis of resected endometrial tissues by hysteroscopy was assessed and the adjusted sensitivity and specificity of 3-DHS and hysteroscopy in detection of polyp or hyperplasia were determined. Histopathologic results were...
Bookmarks Related papers MentionsView impact
Poster: "ECR 2013 / C-1198 / Ultrasonographic screening of major structural anomalies during... more Poster: "ECR 2013 / C-1198 / Ultrasonographic screening of major structural anomalies during the NT examinationsin infertile patients" by: "M. Niknejadi; Tehran/IR"
Bookmarks Related papers MentionsView impact
The Journal of Maternal-Fetal & Neonatal Medicine
Bookmarks Related papers MentionsView impact
Cytotherapy
Bookmarks Related papers MentionsView impact
Cytotherapy, 2018
In this study, we intend to assess the safety and tolerability of intra-articular knee implantati... more In this study, we intend to assess the safety and tolerability of intra-articular knee implantation of autologous bone marrow-derived mesenchymal stromal cells (MSCs) in patients with rheumatoid arthritis (RA) and to determine the preliminary clinical efficacy data in this population. The trial registration numbers are as follows: Royan Institute Ethics Committee: AC/91/1133; NCT01873625. This single-center, randomized, triple-blind, placebo-controlled phase 1/2 clinical trial randomized RA patients with knee involvement to receive either an intra-articular knee implantation of 40 million autologous bone marrow-derived MSCs per joint or normal saline (placebo). Patients were followed up for 12 months to assess therapy outcomes. A total of 30 patients, 15 in the MSC group and 15 in the placebo group, enrolled in this study. There were no adverse effects reported after MSC administration or during follow-up. Patients who received MSCs had superior findings according to the Western Ont...
Bookmarks Related papers MentionsView impact
Iranian Journal of Radiology, 2017
Bookmarks Related papers MentionsView impact
Iranian Journal of Radiology, 2016
Bookmarks Related papers MentionsView impact
Uploads
Papers by Maryam Niknejadi