Papers by Mandana Donoghue
Medical Hypotheses, Aug 1, 2022
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Journal of Oral and Maxillofacial Pathology, 2011
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CODS - journal of dentistry, 2012
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Journal of Oral and Maxillofacial Pathology : JOMFP, 2020
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Journal of Forensic Dental Sciences, 2013
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Journal of Microscopy and Ultrastructure, 2022
Objectives:The purpose of this study was to compare the efficacy of prebreakfast tooth brushing (... more Objectives:The purpose of this study was to compare the efficacy of prebreakfast tooth brushing (PrBTB) and postbreakfast tooth brushing (PoBTB) with or without a prebrushing rinse in caries prevention through the estimation of Streptococcus mutans count.Materials and Methods:Sixty consenting dental students were divided into three age-matched groups of 20 each and instructed to follow prebreakfast, postbreakfast tooth brushing, and prebreakfast rinsing plus PoBTB using the Bass technique. Plaque samples were collected at the start and at the end of every quarter for a total of 6 quarters (18 months) for the evaluation of S. mutans colony-forming unit (CFU) counts. The decayed missing filled surface (DMFS) index of participants was also recorded and compared at the beginning and end of the study period.Results:The post-breakfast tooth brushing group with pre-breakfast rinse (RPoBTB) and without pre-breakfast rinse (PoBTB) showed a highly significant reduction in total S. mutans CFU counts per ml (38% and 29% respectively) at the end of the study. The changes in DMFS value were not significant and did not show any correlation with the S. mutans counts.Conclusion:Our study revealed that PoBTB with or without a prebreakfast rinse reduces the total counts of the cariogenic bacteria S. mutans more efficiently than PrBTB. Although further proof in the form of clinical trials is essential, this study provides the proof of concept for a minor change in the tooth brushing habit, which can significantly enhance caries prevention.
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CODS - journal of dentistry, 2013
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Journal of Oral and Maxillofacial Pathology
Background: Antiasthmatic medications such as β2 agonists and corticosteroids have shown potentia... more Background: Antiasthmatic medications such as β2 agonists and corticosteroids have shown potential side effects such as increased caries risk and oral candidiasis. Studies evaluating microbial changes in adult asthmatics are very scanty in the literature. The present study aimed to evaluate the effects of asthma and its medication on cariogenic bacteria and Candida albicans in adult asthmatics. Aim and Objectives: Our aim was to evaluate and compare counts of Streptococcus mutans (SM) and lactobacilli in plaque and C. albicans in saliva samples of adult asthmatics with controls and during the course of medication longitudinally. Methodology: Samples were collected from twenty recently diagnosed asthmatic adults and twenty controls for estimation of microbial counts at baseline and at 3rd and 6th month after initiation of medication among cases. Results: Asthmatics at baseline had higher microbial counts than controls, but the difference was not statistically significant. Comparison between asthmatics at baseline and 3rd month after initiation of medication showed an increase in counts of SM, lactobacilli and decreased C. albicans counts though the difference was not significant. Comparison between asthmatics at baseline and 6th month and also between 3rd and 6th month showed significantly increased counts of SM. Although there was an increase in counts of lactobacilli and decreased C. albicans counts, significant results were not noted. Asthmatics showed increased microbial counts than controls overall. Conclusion: Asthmatics were found to have higher microbial counts than controls at baseline. Increase in SM and lactobacilli counts in asthmatics after medication emphasizes the need to monitor these patients regularly.
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CODS - journal of dentistry, 2011
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Biohealth Science Bulletin, 2010
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Cancer Science & Research: Open Access, 2015
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Journal of oral and maxillofacial pathology : JOMFP
Oral submucous fibrosis (OSF) is a multi-causal inflammatory reaction to the chemical or mechanic... more Oral submucous fibrosis (OSF) is a multi-causal inflammatory reaction to the chemical or mechanical trauma caused due to exposure to arecanut containing products with or without tobacco (ANCP/T). Arecanut and additional components such as lime and chewing tobacco render ANCP/T highly alkaline. Fibrosing repair is a common reaction to an alkaline exposure in the skin. OSF may be related to the alkaline exposure by ANCP/T in a similar manner. The study was aimed at establishing the relationship of habit-associated salivary pH changes and OSF. The study design was controlled cross-sectional. Base line salivary pH (BLS pH), salivary pH after chewing the habitual ANCP/T substance, post chew salivary pH (PCSpH) for 2 min and salivary pH recovery time (SpHRT) were compared in 30 OSF patients and 30 sex-matched individuals with ANCP/T habits and apparently healthy oral mucosa. The group's mean BLSpH values were similar and within normal range and representative of the population level v...
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Journal of Oral and Maxillofacial Pathology, 2015
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Journal of Forensic Dental Sciences, 2015
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The Open Dentistry Journal, 2015
A 24 year-old male was presented for the diagnosis of an asymptomatic bony expansion in relation ... more A 24 year-old male was presented for the diagnosis of an asymptomatic bony expansion in relation to the right maxillary canine and first premolar. The unilocular radiolucent lesion with central foci of calcification had caused divergence of canine and first premolar roots without any resorption. This case report details a diagnosis of two distinct disease processes of different cellular origin namely, focal cemento-ossifying dysplasia and adenomatoid odontogenic tumor in a previously unreported concomitant and contiguous relationship. The diagnosis was determined by a combination of clinical, radiographic, histopathological and surgical evidence. This case highlights two points, first the need to examine all mixed radiolucent-radiopaque lesions with advanced imaging techniques to assess the number and extent of the lesions prior to treatment planning. Second a likely role of periodontal ligament as the tissue source for odontogenic epithelial cells and mesenchymal stem cells require...
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Journal of Natural Science, Biology and Medicine, 2015
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Journal of Otology & Rhinology, 2015
Mucocutaneous Verruca Vulgaris: A Rare Presentation in an Immunocompetent Patient Cutaneous warts... more Mucocutaneous Verruca Vulgaris: A Rare Presentation in an Immunocompetent Patient Cutaneous warts encountered in Verruca vulgaris are easily recognized by the medical professionals. The mucosal counterparts in the oral cavity are, however, rarely seen in the medical practice. Overall the verrucopapillary lesions of the oral cavity are rare, and difficulties may, therefore, be encountered in diagnosing this lesion. Thorough clinical and histopathological examinations along with a relevant habit history are often essential in reaching a diagnosis. Early identification and eradication of the lesion is crucial in the prevention of further transmission, tissue destruction and rarely malignant transformation.
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Journal of Nepal Dental Assoiation, 2010
ABSTRACT Objective: Carcinoma is an uncontrolled multiplication of cells, such cell production re... more ABSTRACT Objective: Carcinoma is an uncontrolled multiplication of cells, such cell production requires to replace lost cells, that will place a strain on all normal processes and deplete normal stores, one very important component for every cell is the lipid used in its cell wall. This large scale unplanned cell production would deplete cholesterol stores and possibly manifest as a fall of lipid values. Hence the present study was carried out to evaluate changes in plasma lipid profi le in patients with oral precancerous conditions and to evaluate if any relation exists between the plasma lipid level and malignant potential. Methods: A total sample size of 56 subjects was chosen, with the study group consisting of a total of 28 patients 14 with OFS and 14 with LP. The control group consisted of 28 sex and age matched individuals, with out any systemic or oral condition. The histopathological confi rmation was done and the patients were recalled with a minimum of 12 hour of fasting for blood examination for complete lipid profi le. Results: The present study showed that 3 parameters (TC, HDL, LDL) of lipid profi le were reduced in Oral Precancerous cases as compared to age and sex matched healthy controls. Statistical Analysis: Mean and Standard Deviation (SD) was calculated for each group. One way ANOVA was used for multiple group comparison and student’s t test (unpaired) for group wise comparison. Diagnostic validity tests were performed using lipid values as biomarkers to differentiate different disease groups with healthy controls. For all the tests p value of 0.05 or less was used for statistical signifi cance Conclusion: The estimation of lipid profi le can be considered as a good marker for increased cell turnover. However this will also have to be confirmed by using a larger sample size.
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Journal of Pharmacy and Bioallied Sciences, 2014
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Papers by Mandana Donoghue