Selective recognition of metal ions is a real challenge for a large range of applications especia... more Selective recognition of metal ions is a real challenge for a large range of applications especially in sorption purposes. The use of ultrasound in the synthesizing and modifying of sodium alginate-based material is investigated, for enhancing the dispersion, degassing, crosslinking processes and enhance the homogeneity of ion imprinted polymer properties. Cobalt imprinted polymer was prepared using an inexpensive and simple ultrasonic-mediated polymerization process that incorporated dual functional monomers, acrylic acid, and 2-Acrylamido-2-methylpropane sulfonic acid to feature a multifunctional of carboxylic and sulfonic groups. SEM, TGA, DTA, and EDX were used to analyze the surface morphology. FT-IR study confirmed that the complexation of the Co-IIP was successfully takes place. The ability of the adsorption of ion imprinted was optimized at pH 5. The increase of the temperature from 27 to 52 °C caused the increase in the adsorption capacity. Batch tests have been performed t...
Abstract Recent advances in nanostructure materials have been developed by new synthetic method t... more Abstract Recent advances in nanostructure materials have been developed by new synthetic method that provides control over size and chemical structure. The utilization of high intensity ultrasound has been investigated for synthesis of nanostructure polymer that is often unavailable by conventional methods. The preparation of emulsion polymer of carboxy methyl cellulose (CMC) as a backbone with grafting of methyl acrylate and acrylic acid has been investigated using ultrasonic irradiation at 15 min and Tween 80 as a surfactant which, hardly formed by conventional co-polymerization methods. Tween 80 was immersed inside the polymer matrix to improve interfacial tension between polymer and outer sphere water molecule, as well as to overcome the aggregation and compact of the component inside the polymer which, facilitate the grafting reaction. The influence of surfactant type, ultrasonic time and temperature on the particle morphology was studied. Moreover, Nitrilo tri-acetic acid (NTA) was grafted during the polymerization process to increase the effective function groups and hence increasing the sorption capacity toward Lanthanum (La3+), Cerium (Ce3+), Neodymium (Nd3+), Gadolinum (Gd3+) and Uranium (U4+) metal ions. The results showed relatively high sorption capacity reached to110, 121,169, 131, 158, 198 for La3+, Ce3+, Nd3+, Eu3+, Gd3+ and U4+ mg/g metal ions respectively.
A new selective polymeric composite capped with crown ether was successfully synthesized using N-... more A new selective polymeric composite capped with crown ether was successfully synthesized using N-isopropyl acrylamide copolymerized acrylic acid paired with Dibenzo-18-crown-6, P(NIPAm-Co-AA-DB 18C-6), by Gamma irradiation and ultrasonic homogenizer polymerization. Scanner electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and dynamic light scattering were used to characterize the selected polymeric composite's chemical and physical constitution. SEM shows a rough irregular surface, and FTIR spectra confirmed the function groups of P(NIPAm-Co-AA-DB 18C-6). Moreover, a systematic study of monomer and crown ether concentration was investigated to enhance the composite's performance. The behavior of the synthetic composite toward the selective separation of Co-60 from Cs-137 in a binary system was evaluated. Effects of pH, contact time, and initial ion concentration were investigated in a batch mode and the maximum capacity reached 108.0 mg/g for Co-60 a...
Susceptibility-weighted image (SWI) is a T2* gradient echo sequence, which is highly sensitive to... more Susceptibility-weighted image (SWI) is a T2* gradient echo sequence, which is highly sensitive to substances that have magnetic properties. The phase and magnitude of SWI can play an important role in the diagnosis of several diseases. The phase data is highly affected by spatial variations in the main magnetic field of the magnetic resonance imaging (MRI) scanner. The axial acquisition is the frequent plane alignment while acquiring SWI in diagnostic imaging. Clinical requirements often lead to changing of the alignment angles due to variability in patient positioning and anatomy. For many patients undergoing brain MRI, the line of the anterior and posterior commissure AC-PC can vary in direction with respect to the transverse plane of the MRI system. We investigated whether there exist significant effect on phase data of SWI, and this is due to oblique orientation. The obtained results showed significant differences in phase values between axial and anatomically alignments.
Abstract Diclofenac is considered one of the best drugs used as anti-inflammatory agent, so in th... more Abstract Diclofenac is considered one of the best drugs used as anti-inflammatory agent, so in the present work new diclofenac derivatives containing bioactive moieties, such as triazole, oxadiazole, and thiadiazol, were synthesized. The structures of the new compounds were established based on spectral and elemental analysis. The new synthesized compounds were tested against anti-inflammatory agents and exhibited high activity as expected. The binding position of new diclofenac derivatives toward Cox-1 and Cox-2 enzymes was proved by molecular docking. Also, some of the new compounds were tested against bacteria and displayed high activity.
According to the World Health Organization, Malaria is still a dangerous disease. Efforts to disc... more According to the World Health Organization, Malaria is still a dangerous disease. Efforts to discover and cure it are widely required. In this work, 2D photonic crystal (PhC) biomedical sensors based on the index of refraction are designed, simulated, and evaluated. The target is to propose two designs to detect effective stages of Malaria. The first design can be fabricated based on today’s technology, and it has remarkable sensitivity with reasonable quality factors and compactness with size 11.4 × 9.2 µm2. The second one requires advanced fabrication techniques, but it has ultra-quality factors with reasonable sensitivity and compactness with size 9.4 × 5.5 µm2. The operating wavelength for both structures is 1.55 µm. These performance indicators exceed corresponding levels in all literature discusses Malaria detectors. A comparison between the presented work and others based on several technologies is carried to prove the validity and effectiveness of the proposed designs.
Background: Assessment of cell proliferation through the evaluation of cyclin D1, AgNORs, and DNA... more Background: Assessment of cell proliferation through the evaluation of cyclin D1, AgNORs, and DNA content provides a promising approach to the prognosis of breast cancer. Therefore, this work aimed to evaluate the prognostic significance of AgNORs and DNA image cytometry, and their relation to cyclin D1 immunoreactivity in breast cancer. Subjects and methods: This study was carried out on 50 prospective biopsies taken from patients with breast tumors. They were divided into control (10 cases) and benign (10 cases) as well as malignant (30 cases) groups. Computer-assisted image analysis cytometry is applied to evaluate the count of positive reactions of AgNORs and Journal of Medical and Life Science, 2020, Vol.2, No. 4, P.54 -68 pISSN: 2636-4093, eISSN: 2636-4107 55 cyclin D1, and an integrated optical density (IOD) technique is used to quantify DNA content in the tissues stained by Feulgen stain and to assess the density of cyclin D1 immunoreactivity. Results: The comparison between...
Five methanol extracts obtained from five plant species selected according ethnobotanical data we... more Five methanol extracts obtained from five plant species selected according ethnobotanical data were screened for their antiprotozoal activity against Plasmodium falciparum, Leishmania infantum, Trypanosoma cruzi and Trypanosoma brucei. Cytotoxicity was evaluated on MRC-5 cells. Withania somnifera methanol extract showed low activity against P. falciparum (IC50 17.7 μg ml -1 ), but with non-selective antimalarial activity. Most of the extracts tested against L. infantum exhibited low activity with IC50 ranging from 20 to 32 μg ml -1 , except W. somnifera which showed a remarkable but non-selective leishmanicidal activity (IC50 of 2.0 μg ml -1 ). W. somnifera methanol extract also exhibited a marked activity against T cruzi (IC50 0.6 μg ml -1 , SI=3.5).
Selective recognition of metal ions is a real challenge for a large range of applications especia... more Selective recognition of metal ions is a real challenge for a large range of applications especially in sorption purposes. The use of ultrasound in the synthesizing and modifying of sodium alginate-based material is investigated, for enhancing the dispersion, degassing, crosslinking processes and enhance the homogeneity of ion imprinted polymer properties. Cobalt imprinted polymer was prepared using an inexpensive and simple ultrasonic-mediated polymerization process that incorporated dual functional monomers, acrylic acid, and 2-Acrylamido-2-methylpropane sulfonic acid to feature a multifunctional of carboxylic and sulfonic groups. SEM, TGA, DTA, and EDX were used to analyze the surface morphology. FT-IR study confirmed that the complexation of the Co-IIP was successfully takes place. The ability of the adsorption of ion imprinted was optimized at pH 5. The increase of the temperature from 27 to 52 °C caused the increase in the adsorption capacity. Batch tests have been performed t...
Abstract Recent advances in nanostructure materials have been developed by new synthetic method t... more Abstract Recent advances in nanostructure materials have been developed by new synthetic method that provides control over size and chemical structure. The utilization of high intensity ultrasound has been investigated for synthesis of nanostructure polymer that is often unavailable by conventional methods. The preparation of emulsion polymer of carboxy methyl cellulose (CMC) as a backbone with grafting of methyl acrylate and acrylic acid has been investigated using ultrasonic irradiation at 15 min and Tween 80 as a surfactant which, hardly formed by conventional co-polymerization methods. Tween 80 was immersed inside the polymer matrix to improve interfacial tension between polymer and outer sphere water molecule, as well as to overcome the aggregation and compact of the component inside the polymer which, facilitate the grafting reaction. The influence of surfactant type, ultrasonic time and temperature on the particle morphology was studied. Moreover, Nitrilo tri-acetic acid (NTA) was grafted during the polymerization process to increase the effective function groups and hence increasing the sorption capacity toward Lanthanum (La3+), Cerium (Ce3+), Neodymium (Nd3+), Gadolinum (Gd3+) and Uranium (U4+) metal ions. The results showed relatively high sorption capacity reached to110, 121,169, 131, 158, 198 for La3+, Ce3+, Nd3+, Eu3+, Gd3+ and U4+ mg/g metal ions respectively.
A new selective polymeric composite capped with crown ether was successfully synthesized using N-... more A new selective polymeric composite capped with crown ether was successfully synthesized using N-isopropyl acrylamide copolymerized acrylic acid paired with Dibenzo-18-crown-6, P(NIPAm-Co-AA-DB 18C-6), by Gamma irradiation and ultrasonic homogenizer polymerization. Scanner electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and dynamic light scattering were used to characterize the selected polymeric composite's chemical and physical constitution. SEM shows a rough irregular surface, and FTIR spectra confirmed the function groups of P(NIPAm-Co-AA-DB 18C-6). Moreover, a systematic study of monomer and crown ether concentration was investigated to enhance the composite's performance. The behavior of the synthetic composite toward the selective separation of Co-60 from Cs-137 in a binary system was evaluated. Effects of pH, contact time, and initial ion concentration were investigated in a batch mode and the maximum capacity reached 108.0 mg/g for Co-60 a...
Susceptibility-weighted image (SWI) is a T2* gradient echo sequence, which is highly sensitive to... more Susceptibility-weighted image (SWI) is a T2* gradient echo sequence, which is highly sensitive to substances that have magnetic properties. The phase and magnitude of SWI can play an important role in the diagnosis of several diseases. The phase data is highly affected by spatial variations in the main magnetic field of the magnetic resonance imaging (MRI) scanner. The axial acquisition is the frequent plane alignment while acquiring SWI in diagnostic imaging. Clinical requirements often lead to changing of the alignment angles due to variability in patient positioning and anatomy. For many patients undergoing brain MRI, the line of the anterior and posterior commissure AC-PC can vary in direction with respect to the transverse plane of the MRI system. We investigated whether there exist significant effect on phase data of SWI, and this is due to oblique orientation. The obtained results showed significant differences in phase values between axial and anatomically alignments.
Abstract Diclofenac is considered one of the best drugs used as anti-inflammatory agent, so in th... more Abstract Diclofenac is considered one of the best drugs used as anti-inflammatory agent, so in the present work new diclofenac derivatives containing bioactive moieties, such as triazole, oxadiazole, and thiadiazol, were synthesized. The structures of the new compounds were established based on spectral and elemental analysis. The new synthesized compounds were tested against anti-inflammatory agents and exhibited high activity as expected. The binding position of new diclofenac derivatives toward Cox-1 and Cox-2 enzymes was proved by molecular docking. Also, some of the new compounds were tested against bacteria and displayed high activity.
According to the World Health Organization, Malaria is still a dangerous disease. Efforts to disc... more According to the World Health Organization, Malaria is still a dangerous disease. Efforts to discover and cure it are widely required. In this work, 2D photonic crystal (PhC) biomedical sensors based on the index of refraction are designed, simulated, and evaluated. The target is to propose two designs to detect effective stages of Malaria. The first design can be fabricated based on today’s technology, and it has remarkable sensitivity with reasonable quality factors and compactness with size 11.4 × 9.2 µm2. The second one requires advanced fabrication techniques, but it has ultra-quality factors with reasonable sensitivity and compactness with size 9.4 × 5.5 µm2. The operating wavelength for both structures is 1.55 µm. These performance indicators exceed corresponding levels in all literature discusses Malaria detectors. A comparison between the presented work and others based on several technologies is carried to prove the validity and effectiveness of the proposed designs.
Background: Assessment of cell proliferation through the evaluation of cyclin D1, AgNORs, and DNA... more Background: Assessment of cell proliferation through the evaluation of cyclin D1, AgNORs, and DNA content provides a promising approach to the prognosis of breast cancer. Therefore, this work aimed to evaluate the prognostic significance of AgNORs and DNA image cytometry, and their relation to cyclin D1 immunoreactivity in breast cancer. Subjects and methods: This study was carried out on 50 prospective biopsies taken from patients with breast tumors. They were divided into control (10 cases) and benign (10 cases) as well as malignant (30 cases) groups. Computer-assisted image analysis cytometry is applied to evaluate the count of positive reactions of AgNORs and Journal of Medical and Life Science, 2020, Vol.2, No. 4, P.54 -68 pISSN: 2636-4093, eISSN: 2636-4107 55 cyclin D1, and an integrated optical density (IOD) technique is used to quantify DNA content in the tissues stained by Feulgen stain and to assess the density of cyclin D1 immunoreactivity. Results: The comparison between...
Five methanol extracts obtained from five plant species selected according ethnobotanical data we... more Five methanol extracts obtained from five plant species selected according ethnobotanical data were screened for their antiprotozoal activity against Plasmodium falciparum, Leishmania infantum, Trypanosoma cruzi and Trypanosoma brucei. Cytotoxicity was evaluated on MRC-5 cells. Withania somnifera methanol extract showed low activity against P. falciparum (IC50 17.7 μg ml -1 ), but with non-selective antimalarial activity. Most of the extracts tested against L. infantum exhibited low activity with IC50 ranging from 20 to 32 μg ml -1 , except W. somnifera which showed a remarkable but non-selective leishmanicidal activity (IC50 of 2.0 μg ml -1 ). W. somnifera methanol extract also exhibited a marked activity against T cruzi (IC50 0.6 μg ml -1 , SI=3.5).
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