Papers by Lars von Knorring
Journal of studies on alcohol, Sep 1, 1985
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Nordic Journal of Psychiatry, Aug 4, 2021
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Journal of International Medical Research, 1980
A double-blind controlled study of viloxazine against placebo in elderly depressed patients with ... more A double-blind controlled study of viloxazine against placebo in elderly depressed patients with a primary diagnosis of depressive illness records statistically significant improvements in depression ratings in the viloxazine group after three weeks. Viloxazine was effective and well tolerated at doses of 100 to 200 mg in depressed elderly patients, several of whom had concurrent cardiac disease.
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PubMed, Oct 1, 1996
The prevalence of depressive disorders appears to be on the increase, and age at onset to be succ... more The prevalence of depressive disorders appears to be on the increase, and age at onset to be successively declining. In most cases, it is a question of a lifelong disorder with recurrent episodes, which it has been estimated will occupy 20 per cent of the patient's remaining lifespan. As a group, patients with depressive disorders are characterised by high mortality (even if suicide cases are excluded) on a par with the rates for cancer, diabetes and ischaemic heart disease: they often have somatic disorders, and are high consumers of pharmaceutical drugs of all categories. Modern classification systems with well defined criteria for the depressive disorders and new drugs have facilitated treatment. Studies have shown that increased knowledge among GPs of the diagnosis and treatment of depressive disorders can have a pronounced effect on the level of public health.
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The experience of pain in patients with depressive disorders : a clinical and experimental study
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Advances in biological psychiatry, Apr 16, 2015
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Pain, 1983
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Acta Psychiatrica Scandinavica, Aug 1, 1983
ABSTRACT— The aim of this study was to evaluate the safety of zimeldine, a 5‐HT reuptake inhibito... more ABSTRACT— The aim of this study was to evaluate the safety of zimeldine, a 5‐HT reuptake inhibitor, in the long‐term treatment of depressive disorders. The study was an open label, multicentre investigation involving 147 patients who were suffering from depressive illness and who needed long‐term antidepressant treatment. Sixty‐five patients completed the intended treatment period of 1 year, 75 terminated prematurely, and 7 are still in the programme. The reasons for termination were mainly ineffectiveness of the drug and adverse reactions. During the long‐term treatment the most common emergent symptoms were, in order of decreasing frequency, dizziness, dry mouth, sleep disorders, sweating, tremor, nausea and headache. The side‐effects were, however, mild and they generally decreased during the treatment period. No new adverse symptoms were reported. In the long‐term treatment group, body weight showed a slight mean decrease. Clinical chemistry and cardiovascular investigations were judged to show no changes of clinical importance. It is concluded that zimeldine was shown to be a safe drug in this 1‐year treatment programme of depression.
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Biological Psychiatry, May 1, 1988
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Sleep disorders, 2016
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Neuropsychobiology, 1978
19 patients with bipolar affective disorders were investigated with visual averaged evoked respon... more 19 patients with bipolar affective disorders were investigated with visual averaged evoked responses (V.AER) to different stimulus intensities. 7 patients were investigated only in the depressive phase, 8 only in the manic phase, 2 in both the depressive and the manic phase, 1 in the manic phase and after recovery, and 1 patient was followed in both the depressive and the manic phase and when recovered. Both the comparisons between the independent groups and the results from the individual patients followed in different phases of the disorder indicate that patients in the depressive phase have a tendency to decrease in maximum amplitude when stimulus intensity is increased (reducing). Patients in the manic phase, on the other hand, show increasing maximum amplitude with increasing stimulus intensity (augmenting). The biochemical basis for this switch in augmenting/reducing tendency seem to be changes in the activity in the monoaminergic systems.
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Deprimerade patienter - okad sarbarhet och okad dodlighet. Sammanfattning fran symposium om Sarba... more Deprimerade patienter - okad sarbarhet och okad dodlighet. Sammanfattning fran symposium om Sarbarhet vid depression, Uppsala, Nov 1997
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Papers by Lars von Knorring