Rationale d-Serine is an endogenous co-agonist of the N-methyl-d-aspartate (NMDA) receptor and ha... more Rationale d-Serine is an endogenous co-agonist of the N-methyl-d-aspartate (NMDA) receptor and has been suggested to improve cognitive deficits in schizophrenia. Objectives The present study investigates the effects of treatment with d-serine in mice on tasks that require recognition learning and working memory, two cognitive domains that are impaired in schizophrenia. Methods We studied the effects of various regimens of systemic administration of d-serine (50 mg/kg/day) on BALB/c mice performing object recognition, T-maze alternation, and open-field exploration tasks. For the object recognition task, we also contrasted the effects of d-serine and d-cycloserine and investigated whether d-serine could reverse alterations induced by subchronic injections of the NMDA antagonist MK-801. d-Serine levels after injections were measured by high-performance liquid chromatography. Results In the object recognition task, pre-training treatment with d-serine or d-cycloserine significantly enhanced recognition memory 24 h after training. A single administration of d-serine 30 min (but not 6 h) after training produced similar enhancement, suggesting an effect on memory consolidation. Daily treatment with d-serine enhanced both object recognition and T-maze performance over multiple days and improved short-term memory in MK-801-treated mice. d-Serine treatment did not alter open-field exploration. Behavioral effects were accompanied by increased levels of d-serine in the hippocampus of treated animals. Conclusions Our results show that treatment with d-serine can improve performance in tasks related to recognition learning and working memory, suggesting that this agent can be useful for the treatment of disorders involving declines in these cognitive domains.
A detailed study is presented of the expected performance of the ATLAS detector. The reconstructi... more A detailed study is presented of the expected performance of the ATLAS detector. The reconstruction of tracks, leptons, photons, missing energy and jets is investigated, together with the performance of b-tagging and the trigger. The physics potential for a variety of interesting physics processes, within the Standard Model and beyond, is examined. The study comprises a series of notes based on simulations of the detector and physics processes, with particular emphasis given to the data expected from the first years of operation of the LHC at CERN.
The T2K experiment observes indications of $\nu_\mu\rightarrow \nu_e$ appearance in data accumula... more The T2K experiment observes indications of $\nu_\mu\rightarrow \nu_e$ appearance in data accumulated with $1.43\times10^{20}$ protons on target. Six events pass all selection criteria at the far detector. In a three-flavor neutrino oscillation scenario with $|\Delta m_{23}^2|=2.4\times10^{-3}$ eV$^2$, $\sin^2 2\theta_{23}=1$ and $\sin^2 2\theta_{13}=0$, the expected number of such events is 1.5$\pm$0.3(syst.). Under this hypothesis, the probability to observe six or more candidate events is 7$\times10^{-3}$, equivalent to 2.5$\sigma$ significance. At 90% C.L., the data are consistent with 0.03(0.04)$<\sin^2 2\theta_{13}<$ 0.28(0.34) for $\delta_{\rm CP}=0$ and a normal (inverted) hierarchy.
... Struma Ovarii and Concomitant Thyroid Disease: Report of Two Cases. Taboada, Giselle F. MD; S... more ... Struma Ovarii and Concomitant Thyroid Disease: Report of Two Cases. Taboada, Giselle F. MD; Sieiro, Ana Paula V. MD; Alanati, Luise MD; Guimarães, Marília M. MD, PhD; Vaisman, Mário MD, PhD. Article Outline. Collapse Box Author Information. ... A, Bezerra AM, Serafini LN. ...
Rationale d-Serine is an endogenous co-agonist of the N-methyl-d-aspartate (NMDA) receptor and ha... more Rationale d-Serine is an endogenous co-agonist of the N-methyl-d-aspartate (NMDA) receptor and has been suggested to improve cognitive deficits in schizophrenia. Objectives The present study investigates the effects of treatment with d-serine in mice on tasks that require recognition learning and working memory, two cognitive domains that are impaired in schizophrenia. Methods We studied the effects of various regimens of systemic administration of d-serine (50 mg/kg/day) on BALB/c mice performing object recognition, T-maze alternation, and open-field exploration tasks. For the object recognition task, we also contrasted the effects of d-serine and d-cycloserine and investigated whether d-serine could reverse alterations induced by subchronic injections of the NMDA antagonist MK-801. d-Serine levels after injections were measured by high-performance liquid chromatography. Results In the object recognition task, pre-training treatment with d-serine or d-cycloserine significantly enhanced recognition memory 24 h after training. A single administration of d-serine 30 min (but not 6 h) after training produced similar enhancement, suggesting an effect on memory consolidation. Daily treatment with d-serine enhanced both object recognition and T-maze performance over multiple days and improved short-term memory in MK-801-treated mice. d-Serine treatment did not alter open-field exploration. Behavioral effects were accompanied by increased levels of d-serine in the hippocampus of treated animals. Conclusions Our results show that treatment with d-serine can improve performance in tasks related to recognition learning and working memory, suggesting that this agent can be useful for the treatment of disorders involving declines in these cognitive domains.
A detailed study is presented of the expected performance of the ATLAS detector. The reconstructi... more A detailed study is presented of the expected performance of the ATLAS detector. The reconstruction of tracks, leptons, photons, missing energy and jets is investigated, together with the performance of b-tagging and the trigger. The physics potential for a variety of interesting physics processes, within the Standard Model and beyond, is examined. The study comprises a series of notes based on simulations of the detector and physics processes, with particular emphasis given to the data expected from the first years of operation of the LHC at CERN.
The T2K experiment observes indications of $\nu_\mu\rightarrow \nu_e$ appearance in data accumula... more The T2K experiment observes indications of $\nu_\mu\rightarrow \nu_e$ appearance in data accumulated with $1.43\times10^{20}$ protons on target. Six events pass all selection criteria at the far detector. In a three-flavor neutrino oscillation scenario with $|\Delta m_{23}^2|=2.4\times10^{-3}$ eV$^2$, $\sin^2 2\theta_{23}=1$ and $\sin^2 2\theta_{13}=0$, the expected number of such events is 1.5$\pm$0.3(syst.). Under this hypothesis, the probability to observe six or more candidate events is 7$\times10^{-3}$, equivalent to 2.5$\sigma$ significance. At 90% C.L., the data are consistent with 0.03(0.04)$<\sin^2 2\theta_{13}<$ 0.28(0.34) for $\delta_{\rm CP}=0$ and a normal (inverted) hierarchy.
... Struma Ovarii and Concomitant Thyroid Disease: Report of Two Cases. Taboada, Giselle F. MD; S... more ... Struma Ovarii and Concomitant Thyroid Disease: Report of Two Cases. Taboada, Giselle F. MD; Sieiro, Ana Paula V. MD; Alanati, Luise MD; Guimarães, Marília M. MD, PhD; Vaisman, Mário MD, PhD. Article Outline. Collapse Box Author Information. ... A, Bezerra AM, Serafini LN. ...
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