Papers by Lorenzo Fantini
JCO precision oncology, Dec 1, 2019
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Therapeutic Advances in Medical Oncology, 2021
Background: The aim of this study was to improve activity over single human epidermal growth fact... more Background: The aim of this study was to improve activity over single human epidermal growth factor receptor 2 (HER2)-blockade sequential neaodjuvant regimens for HER2-positive breast cancer, by exploiting the concomitant administration of trastuzumab, taxane and anthracycline, while restraining cardiac toxicity with use of liposomal doxorubicin, and by adding metformin, based on preliminary evidence of antitumor activity. Patients and methods: This multi-center, single-arm, two-stage phase II trial, assessed the safety and the activity of a new treatment regimen for HER2-positive, early or locally advanced breast cancer. Patients received six 21-day cycles of non-pegylated liposomal doxorubicin, 50 mg/m2 intravenously (i.v.) on day 1, docetaxel, 30 mg/m2 i.v. on days 2 and 9, trastuzumab, 2 mg/kg/week i.v. on days 2, 9, and 16 (with 4 mg/kg loading dose), in association with metformin 1000 mg orally twice daily. The primary endpoint was the rate of pathological complete response (p...
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The Journal of Nuclear Medicine, 2010
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European Journal of Nuclear Medicine and Molecular Imaging, 2020
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European Journal of Nuclear Medicine and Molecular Imaging, 2017
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Proteases in Biology and Disease
... Chappell MC, Diz DI, Gallagher PE, 2001, The renin-angiotensin system and the exocrine pancre... more ... Chappell MC, Diz DI, Gallagher PE, 2001, The renin-angiotensin system and the exocrine pancreas. ... Fishman MP, Melton DA., 2002, Pancreatic lineage analysis using a retroviral vector in embryonic mice demonstrates a common progenitor for endocrine and exocrine cells. ...
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World Journal of Gastroenterology, 2006
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JOP : Journal of the pancreas, Jan 10, 2007
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Advances in medical sciences, 2007
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Pancreas, 2008
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Pancreatology, 2007
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Digestive and Liver Disease, 2005
Introduction.Health-related quality of life is becoming a major issue in the evaluation of any th... more Introduction.Health-related quality of life is becoming a major issue in the evaluation of any therapeutic intervention in patients with chronic or hard to cure diseases.
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Clinical Nuclear Medicine, 2013
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Annals of Nuclear Medicine, 2010
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Frontiers in Oncology
PurposeThe objective of this study was to evaluate a set of radiomics-based advanced textural fea... more PurposeThe objective of this study was to evaluate a set of radiomics-based advanced textural features extracted from 18F-FLT-PET/CT images to predict tumor response to neoadjuvant chemotherapy (NCT) in patients with locally advanced breast cancer (BC).Materials and MethodsPatients with operable (T2-T3, N0-N2, M0) or locally advanced (T4, N0-N2, M0) BC were enrolled. All patients underwent chemotherapy (six cycles every 3 weeks). Surgery was performed within 4 weeks of the end of NCT. The MD Anderson Residual Cancer Burden calculator was used to evaluate the pathological response. 18F-FLT-PET/CT was performed 2 weeks before the start of NCT and approximately 3 weeks after the first cycle. The evaluation of PET response was based on EORTC criteria. Standard uptake value (SUV) statistics (SUVmax, SUVpeak, SUVmean), together with 148 textural features, were extracted from each lesion. Indices that are robust against contour variability (ICC test) were used as independent variables to l...
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Digestive Diseases and Sciences, 2007
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European journal of nuclear medicine and molecular imaging, Mar 6, 2017
The role of 18F-choline positron emission tomography/computed tomography (FCH-PET/CT) in patients... more The role of 18F-choline positron emission tomography/computed tomography (FCH-PET/CT) in patients with metastatic castration-resistant prostate cancer (mCRPC) has been firmly established in recent years. We analyzed the prognostic value of functional parameters such as mean standardized uptake volume (SUVmean), maximum standardized uptake volume (SUVmax), metabolic total volume (MTV; the volume of interest consisting of all spatially connected voxels within a fixed threshold of 40% of the SUVmax), and total lesion activity (TLA: the product of MTV and mean standardized uptake value) estimated with FCH-PET/CT in mCRPC patients in progression after docetaxel and treated with new antiandrogen receptor therapies, abiraterone or enzalutamide. We retrospectively studied 94 mCRPC patients, mean age 74 years (range 42-90), previously treated with docetaxel who were treated with either abiraterone (n = 52) or enzalutamide (n = 42). An FCH-PET/CT was performed at baseline, and patients were e...
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European Journal of Nuclear Medicine and Molecular Imaging, 2016
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JOP : Journal of the pancreas, Jan 9, 2007
The aim of this paper was to review the data existing in the English literature on the quality of... more The aim of this paper was to review the data existing in the English literature on the quality of life in patients who undergo surgical resection of the pancreatic gland either for benign or for malignant diseases. MEDLINE, Web of Science, and ScienceDirect were browsed in order to select the data existing in the literature on quality of life and pancreatic surgery. Alerts received by e-mail were also taken into account. Only full text papers were selected. Of the 161 papers found, only 13 papers were evaluated for the purpose of this study: 11 focused on surgical resective procedures in chronic pancreatitis and two focused their interest on assessing the quality of life related to resective procedures in pancreatic neoplasms. Despite the scarcity of studies assessing the quality of life in patients who underwent pancreatic surgery, there is the need to routinely assess well-being in patients who have been operated on.
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JOP : Journal of the pancreas, 2007
The only potentially radical treatment for pancreatic cancer is the removal of the tumor which ca... more The only potentially radical treatment for pancreatic cancer is the removal of the tumor which can be performed by total or subtotal surgical resection of the pancreas; this is possible in the early stages of the disease when the tumor is confined to the pancreatic gland without metastasis to the liver, lymph nodes and/or the peritoneum, or involvement of the vascular system such as the celiac trunk and its branches and the superior mesenteric artery. In this paper, we describe the accuracy of computed tomography and positron emission tomography in the diagnosis of exocrine pancreatic cancer.
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Papers by Lorenzo Fantini