Papers by Loic Charbonniere
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Dalton Transactions, 2018
After bulk solids and nanoparticles, examples of upconversion are now emerging at the discrete mo... more After bulk solids and nanoparticles, examples of upconversion are now emerging at the discrete molecular scale in solution.
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Nanoscale
This review aims at providing a survey of the various designs of nanoparticles containing dye-pho... more This review aims at providing a survey of the various designs of nanoparticles containing dye-photosensitized lanthanide ions and their use as luminescent probes, from seminal work to the most recent evolutions.
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Angewandte Chemie, 2018
The release of uranyl(VI) is ah azardous environmental issue,w ith limited ways to monitor accumu... more The release of uranyl(VI) is ah azardous environmental issue,w ith limited ways to monitor accumulation in situ. Here,wepresent amethod for the detection of uranyl(VI) ions through the utilization of au nique fluorescence energy transfer process to europium(III). Our system displays the first example of a" turn-on" europium(III) emission process with asmall, water-soluble lanthanide complex triggered by uranyl-(VI) ions. The development of nuclear technologies has led to many cases of accidental and intentional release of radionuclides, with accumulation of significant levels of uranium in the environment. [1] Of particular concern is the uranyl(VI) cation, UO 2 2+ .T his species,apotent nephrotoxin, [2] is highly mobile in groundwater and biological systems,l eading to possible problematic spread of radiotoxic material following containment breaches. To date,there has been limited development of probes for UO 2 2+ detection, with scintillation counting and X-ray based met...
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European Journal of Inorganic Chemistry, 2021
The surface coordination of p‐sulfonato‐ (C[4]), p‐sulfonatothia‐ (SC[4]) and p‐sulfonato‐sulfoxo... more The surface coordination of p‐sulfonato‐ (C[4]), p‐sulfonatothia‐ (SC[4]) and p‐sulfonato‐sulfoxocalix[4]arene (SO2C[4]) on La0.9Tb0.1F3 nanoparticles (TbNP) was investigated by UV‐Vis absorption and luminescence spectroscopies. SO2C[4] displayed the strongest affinity towards the NPs and a significant antenna effect leading to observation of the characteristic Tb emission bands upon calixarene excitation. NPs decorated by a shell of SO2C[4] were prepared and the interaction with rhodamine 6G (R6G) was studied. The progressive addition of R6G resulted in a strong Tb to R6G energy transfer process, as revealed by a long lived emission of R6G upon SO2C[4] excitation. The FRET efficiency was almost quantitative (87–90 %), pointing to an average distance of 28 to 32 Å between the R6G and the Tb emitting centres of the NP. An association of one R6G per SO2C[4] was deduced with a very strong apparent affinity (K=2.5×107 M−1) in water. Similar interactions were observed with paraquat, resu...
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Chemistry – A European Journal, 2020
Lanthanide‐doped nanoparticles (LnNPs) have become an important class of fluorophores for advance... more Lanthanide‐doped nanoparticles (LnNPs) have become an important class of fluorophores for advanced biosensing and bioimaging. LnNPs that are photosensitized by surface‐attached antenna ligands can possess exceptional brightness. However, their functional bioconjugation remains an important challenge for their translation into bioanalytical applications. To solve this problem, we designed a ligand that can be simultaneously applied as efficient light harvesting antenna for Tb surface ions and strong linker of biomolecules to the LnNPs surfaces. To demonstrate generic applicability of the photosensitized TbNP‐bioconjugates, we applied them in two prototypical applications for biosensing and bioimaging. First, in‐solution biorecognition was shown by time‐resolved Förster resonance energy transfer (FRET) between streptavidin‐functionalized TbNPs to biotinylated dyes (ATTO 610). Second, in situ detection of ligand–receptor binding on cells was accomplished with TbNP‐antibody (Matuzumab) ...
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Angewandte Chemie International Edition, 2020
The search for more biocompatible alternatives to Gd3+‐based MRI agents, and the interest in 52Mn... more The search for more biocompatible alternatives to Gd3+‐based MRI agents, and the interest in 52Mn for PET imaging call for ligands that form inert Mn2+ chelates. Given the labile nature of Mn2+, high inertness is challenging to achieve. The strongly preorganized structure of the 2,4‐pyridyl‐disubstituted bispidol ligand L1 endows its Mn2+ complex with exceptional kinetic inertness. Indeed, MnL1 did not show any dissociation for 140 days in the presence of 50 equiv. of Zn2+ (37 °C, pH 6), while recently reported potential MRI agents MnPyC3A and MnPC2A‐EA have dissociation half‐lives of 0.285 h and 54.4 h under similar conditions. In addition, the relaxivity of MnL1 (4.28 mm−1 s−1 at 25 °C, 20 MHz) is remarkable for a monohydrated, small Mn2+ chelate. In vivo MRI experiments in mice and determination of the tissue Mn content evidence rapid renal clearance of MnL1. Additionally, L1 could be radiolabeled with 52Mn and the complex revealed good stability in biological media.
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Chemistry – A European Journal, 2020
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Chemistry – A European Journal, 2020
The heptadentate ligand L was shown to form an extremely stable Gd complex at neutral pH with a p... more The heptadentate ligand L was shown to form an extremely stable Gd complex at neutral pH with a pGd value of 18.4 at pH 7.4. The X‐ray crystal structures of the complexes formed with Gd and Tb displayed two very different coordination behaviors being, respectively, octa‐ and nonacoordinated. The relaxometric properties of the Gd complex were studied by field‐dependent relaxivity measurements at various temperatures and by 17O NMR spectroscopy. The pH‐dependence of the longitudinal relaxivity profile indicated large changes around neutral pH leading to a very large value of 10.1 mm−1⋅s−1 (60 MHz, 298 K) at pH 4.7. The changes were attributed to an increase of the hydration number from one water molecule in basic conditions to two at acidic pH. A similar trend was observed for the luminescence of the Eu complex, confirming the change in hydration state. DOSY experiments were performed on the Lu analogue, pointing to the absence of dimers in solution in the considered pH range. A breat...
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Coordination Chemistry Reviews, 2020
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Dalton Transactions, 2019
The stabilization of a divalent Europium provides an efficient pathway for the quenching of the l... more The stabilization of a divalent Europium provides an efficient pathway for the quenching of the luminescence in ten-coordinate macrocyclic complexes.
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Angewandte Chemie International Edition, 2018
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Inorganic Chemistry, 2018
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Bioconjugate Chemistry, 2018
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Bioconjugate Chemistry, 2018
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Chemistry (Weinheim an der Bergstrasse, Germany), Jan 12, 2018
In the presence of fluoride anions, [LnL(HO)]complexes, based on the coordination of a lanthanide... more In the presence of fluoride anions, [LnL(HO)]complexes, based on the coordination of a lanthanide (Ln) cation into the cavity of a Csymmetrical cyclen-based ligand (L), self-assemble in water to form [(LnL)F]dimers. The crystal structures of the Yb hydrated monomer and of the fluorinated dimer are reported and analyzed to unravel the impact of the cumulative effect of weak hydrogen bonding and aromatic stacking interactions in the supramolecular assembly. The assembly is stable over a broad range of pH 3-8. A combination of equimolar amounts of Eu and Tb complexes led to a quasistatistical mixture of homo- and heterodimers, as observed by using electrospray mass spectrometry. In the heterodimers, selective excitation into theF→Dabsorption band of the Tb center at λ=488 nm allowed the observation of a Tb-to-Eu downshifting energy transfer, not observed in the absence of fluoride ions. Analysis of the excited-state lifetimes of the dimers within the frame of the Förster theory of ener...
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European Journal of Inorganic Chemistry, 2017
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Inorganic Chemistry, 2017
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Dalton Transactions, 2016
ON–OFF fluorescent chemosensors based on sulphur-rich functionalized calix[4]arenes selectively b... more ON–OFF fluorescent chemosensors based on sulphur-rich functionalized calix[4]arenes selectively bind Hg2+over Cu2+, Zn2+and Cd2+.
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Dalton Transactions, 2016
ON–OFF fluorescent chemosensors based on sulphur-rich functionalized calix[4]arenes selectively b... more ON–OFF fluorescent chemosensors based on sulphur-rich functionalized calix[4]arenes selectively bind Hg2+over Cu2+, Zn2+and Cd2+.
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Papers by Loic Charbonniere