Papers by Leanne Labriola
International Journal of Psychophysiology
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2017 IEEE Healthcare Innovations and Point of Care Technologies (HI-POCT), 2017
In this paper, we present a biosensor chip to study two important biomarkers, lactoferrin (LCF) a... more In this paper, we present a biosensor chip to study two important biomarkers, lactoferrin (LCF) and beta-2-microglubin (B2M) present in our tear fluid. LCF and B2M have direct relevance with dry eye syndrome and diabetic retinopathy in patients respectively. We have developed a multi-layer paper-based biosensor chip connected with handheld printed circuit board (PCB) to monitor the effectiveness of B2M and LCF in contrived tear film (TF) with a wide range of detection (RoD) from 0.001 to 1ng/mL (R2=0.9886) and 1 to 10mg/mL (R2=0.9554) respectively. Multilayer biosensor is composed of graphene nanoplatelet and diblock-co-polymer coated on a filter paper followed by deposition of micro-Au electrodes. Anti-LCF and anti-B2M antibodies were immobilized via 3,3'-dithiodipropionic acid di(N-hydroxysuccinimide ester (DTSP) as a self-assembled monolayer (SAM) on Au. In addition to electrical measurements in real-time setup, Raman spectral analysis and SEM were utilized to characterize the sensor surface before and after testing the relevant proteins. We anticipate that the fabricated sensor chip has promising application to study dry-eye-disease (DED) and diabetes in Point-of-care (POC) setting.
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Investigative Ophthalmology & Visual Science, 2013
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Investigative Ophthalmology & Visual Science, 2012
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Investigative Ophthalmology & Visual Science, 2010
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Investigative Ophthalmology & Visual Science, 2016
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The Journal of Nutrition, 2021
Background Multiple sclerosis (MS) can cause retinal thinning among persons with MS with optic ne... more Background Multiple sclerosis (MS) can cause retinal thinning among persons with MS with optic neuritis (MS-ON). Macular xanthophylls are carotenoids that comprise the macular pigment, filtering blue light and countering photo-oxidation. However, macular xanthophyll status and its implications for markers of neuroaxonal degeneration have not been examined in MS. Objectives This study characterized differences in macular and serum xanthophylls, and retinal morphometry [retinal nerve fiber layer thickness at the macular (mRNFL) and optic disc (odRNFL) and total macular volume (TMV)] in individuals with MS and healthy controls (HC). Associations between macular pigment optical density (MPOD) and retinal morphometry were also examined. Methods Adults aged 45–64 y (HC, n = 42; MS, n = 40) participated in a cross-sectional study. MPOD was measured via heterochromatic flicker photometry. Retinal morphometry was measured via optical coherence tomography (OCT). Serum carotenoids were quantif...
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Journal of VitreoRetinal Diseases, 2020
Purpose: To describe a case with an unusual presentation of Propionibacterium acnes ( P acnes) wi... more Purpose: To describe a case with an unusual presentation of Propionibacterium acnes ( P acnes) with ultimately a good visual outcome. Methods: A case report with review of approaches to P acnes endophthalmitis. Results: We describe a patient with an unusual presentation of P acnes of panuveitis with white, circular preretinal lesions without intracapsular deposits. Diagnosis was made from cultures from pars plana vitrectomy. Eventually, she was definitively managed with capsulectomy, repositioning of her intraocular lens via sutureless intrascleral fixation, and intravitreal vancomycin injection. Conclusion: This is a report of P acnes endophthalmitis presenting with discrete preretinal lesions where surgical and medical management lead to a complete resolution of uveitis and symptoms after a 3-year follow up where the patient’s final visual acuity was Snellen 20/20 OU.
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Current Developments in Nutrition, 2019
Objectives Individuals with multiple sclerosis (MS) often suffer a progressive loss in visual and... more Objectives Individuals with multiple sclerosis (MS) often suffer a progressive loss in visual and cognitive function. While the exact reason for the cognitive decline in MS is unknown, generalized neurodegeneration of the central nervous system has been associated with lower carotenoid levels. Carotenoids have antioxidant effects that could support nerve health and be protective against cognitive decline. Carotenoids are also found in high concentration within the center of the retina, or macula. Their role in the brain may be related to their role in the eye and vision health. We investigated the correlation among macular carotenoids, retinal and nerve fiber layer thickness, and cognitive function in patients with MS. Methods Subjects included persons diagnosed with MS between 45–64 years (N = 29) living in Illinois. Carotenoid accumulation, defined as macular pigment optical density (MPOD), was measured using heterochromatic flicker photometry. Optical coherence tomography (Heidel...
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Journal of VitreoRetinal Diseases, 2019
Purpose: The purpose of this article is to investigate automated segmentation measurements of the... more Purpose: The purpose of this article is to investigate automated segmentation measurements of the outer nuclear layer to differentiate patients with hydroxychloroquine toxicity from healthy individuals. Methods: A 5-year retrospective, case-controlled, interventional study of hydroxychloroquine toxicity patients was conducted. Measurements of the outer nuclear layer were obtained with use of commercially available segmentation software and compared with controls. Results: Seven participants (13 eyes) with toxicity and 16 controls (16 eyes) were included. The data comparing the parafoveal, perifoveal, foveal, and overall regions were significant both in thickness ( P < .0001, P < .0001, P = .0029, and P < .0001, respectively) and volume ( P < .0001, P < .0001, P < .0001, and P < .0001, respectively). The CI indicates there is 95% confidence that toxicity patients have between 147 μm and 201 μm less thickness (average 174 μm) and between 0.39 mm3 and 0.55 mm3 less...
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Biosensors and Bioelectronics, 2018
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The Design Journal, 2017
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ACS applied materials & interfaces, Jan 16, 2017
Lack of current techniques for the early monitoring of bleb leaks and other post-traumatic or pos... more Lack of current techniques for the early monitoring of bleb leaks and other post-traumatic or post-surgical ocular injury has posed an unmet clinical need for the development of new techniques. Present evaluation techniques use either subjective or non-quantitative approaches. At present, there are no FDA approved ocular devices that can directly measure ascorbic acid (AA) concentration levels for both tear film (TF) and aqueous humor (AH) at point-of-care (POC) level. Toward this aim, we present a novel point-of-care (POC) quantitative assay, called the Ocular Biosensor device, which can be used to evaluate the integrity of the anterior surface of the eye by measuring the concentration of AA in TF and AH. Herein, we utilize a novel scientific engineering approach for the development of a disposable paper based POC ocular biosensor strip. A grafted poly(styrene)-block-poly(acrylic acid) (PS-b-PAA) and graphene platelet composite with contour based µ-electrodes design (CBµE) exhibit ...
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Seminars in Ophthalmology, 2016
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RETINAL Cases & Brief Reports, 2016
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Journal of Ophthalmic Inflammation and Infection, 2015
Background The study aims to correlate Fourier-domain optical coherence tomography (FD-OCT) with ... more Background The study aims to correlate Fourier-domain optical coherence tomography (FD-OCT) with Goldmann visual field (GVF) to show the photoreceptor (PR) structure and function relationship in the first described case of cancer-associated retinopathy (CAR) from Merkel cell carcinoma. Findings A case study of a patient with CAR who was imaged with serial GVF and FD-OCT over a 2-year period was carried out. En face images were created using a custom algorithm from the volumetric Fourier-domain OCT scans at the PR level. The areas of decreased PR reflectivity on the en face images were compared with GVF obtained at the same time point. Regions of reduced signal on en face scans corresponded with the position and shape of the GVF scotomas. Initially, the vision improved without PR changes. Cross-sectional OCTs showed early recovery of the outer nuclear layer and later improvement in the nerve fiber layer. Worsening vision corresponded with recurrence of the underlying cancer. Progress...
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Seminars in Ophthalmology, 2009
... Leanne T. Labriola, Thomas R. Friberg Eye and Ear Institute, University of Pittsburgh Medical... more ... Leanne T. Labriola, Thomas R. Friberg Eye and Ear Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. ... Abstract. Hegab SM, Mutawa SA. Immunopathogenesis of toxoplasmosis. Clin Exp Med. 2003 Sept; 3(2):84105. Boothroyd JC, Grigg ME. ...
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Essentials in Ophthalmology, 2010
• Fundus imaging has become an integral part of the retinal examination. • Several techniques o... more • Fundus imaging has become an integral part of the retinal examination. • Several techniques of fundus imaging are available for clinicians and researchers. • The scanning laser ophthalmoscope is an innovative system that is greatly improving fundus imaging because of the advantages it offers over traditional fundus photography. • A specialized scanning laser ophthalmoscope is able to produce a
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International Ophthalmology Clinics, 2012
... Original Articles. Retinal Toxicity of Systemic Medications. Labriola, Leanne T. DO; Jeng, Da... more ... Original Articles. Retinal Toxicity of Systemic Medications. Labriola, Leanne T. DO; Jeng, David MD; Fawzi, Amani A. MD. Article Outline. Collapse Box Author Information. The authors declare that they have no conflicts of interest to disclose. ...
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Proceedings of the International Symposium on Human Factors and Ergonomics in Health Care, 2017
The OcuCheck is a novel ocular device that will disrupt the healthcare industry by reducing the n... more The OcuCheck is a novel ocular device that will disrupt the healthcare industry by reducing the need for Slit Lamps when evaluating corneal integrity. Ocular leaks should be detected and repaired quickly for the best vision outcomes. Patient comfort, user needs, and usability informed the design of the device. Key design objectives included ease of use by persons with all levels of skill, portability, and the ability to assess the patient regardless of the patient’s position or level of consciousness. We utilized a human-centric design approach, driven by the needs of both the patient and medical professionals, to elicit visual cues, patterns of behavior, and product design opportunities. We incorporated sociology, ergonomics, sustainability, human factors, business models, and marketing into the development process early on and worked in parallel with the engineers to integrate the needs of the user from the very beginning. Design, research, and prototype testing were focused upon ...
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Papers by Leanne Labriola