The NHS and Community Care reforms give increased emphasis to meeting the needs of patients as co... more The NHS and Community Care reforms give increased emphasis to meeting the needs of patients as consumers of services, but little is known about patients' perceptions of services. In this study, we obtained the views of patients attending a geriatric day hospital about community care services and professional support; their knowledge of services, perceived unmet needs and perceptions of benefit. Forty-seven patients with a mental status score above 7/10 who attended the day hospital in a four week period were interviewed using structured questionnaires for consumer opinion, modified for this population. Patients had poor knowledge of services, especially of those which support carers and of private sources of support. When informed about the availability and purpose of local services, they recognised few unmet needs on average, less than one per patient, nearly always a need for social services, especially other forms of day care. Patients' perceptions of benefit from services and professional support were highest for day hospital care itself (98% of maximum possible benefit). There could be scope for the development of social work case management programmes in geriatric day hospitals; the methods used in this study provide a model for obtaining consumer opinion.
Nutritional supplements have been commonly used in the poultry industry last few years. The study... more Nutritional supplements have been commonly used in the poultry industry last few years. The study aimed to investigate the epigenetic effects of adding vitamin E and organic selenium to the diet of broiler breeders Ross-308 on their progeny meat production performance. The treatments included the control group fed with a standard diet without supplementation (T1), T2 using a standard diet supplemented with 500 mg of vitamin E / kg, T3 using a standard diet supplemented with 0.5 mg of organic selenium (Availa powder) /kg, and T4 using a standard diet supplemented with a mixture of vitamin E and organic selenium in proportions 500 and 0.5 mg/kg respectively. The eggs were collected from each treatment to obtain the progeny reared for 35 periods, and measurements were recorded for meat production and carcass traits. The results showed that the treatments had significant epigenetic effects on body weight at hatching. Hence, T2 had a significantly heavier body weight than T1, while no si...
Nutrition supplementation in broiler breeder diets are necessary to provide the nutritional requi... more Nutrition supplementation in broiler breeder diets are necessary to provide the nutritional requirements for the optimal performance of the broiler breeder flock after significant genetic improvement of production performance. The study aimed to determine the effect of adding vitamin E and organic selenium to the diet of broiler breeder Rose 308 in the productive and reproductive traits. The experimental flock consist of  60 hens  and 10 cocks at 41 weeks of age. The birds divided into four groups for treatments application, and each treatment had three replicates (five hens per replication). The first treatment T1 fed a standard diet without addition (control) containing 15% crude protein and metabolic energy 2775 kilocalories / kg of diet, and T2 used a standard diet and 500 mg vitamin E / kg of diet supplementation, and T3 used a standard ration plus 0.5 mg of organic selenium (Availa powder) / kg of diet supplementation, and T4 used  a standard diet plus a mixture of vitamin E a...
Silver nanoparticles (AgNPs) are the most common nanomaterials in consumer products. Therefore, i... more Silver nanoparticles (AgNPs) are the most common nanomaterials in consumer products. Therefore, it ‎has been crucial to control AgNPs toxicological effects to improve their safety and increase the outcome of their applications. This work investigated the possible protective effect of thymoquinone (TQ) against ‎AgNPs-induced hepatic and renal cytotoxicity in rats. Serum markers of liver and kidney functions as ‎well as liver and kidney oxidative stress status, pro-inflammatory cytokines, apoptosis markers, and ‎histopathology were assessed. TQ reversed AgNPs-induced elevation in serum liver and kidney function markers, including aspartate transaminase, alanine transaminase, urea, and ‎creatinine. Moreover, TQ co-administration with AgNPs alleviates hepatic and renal oxidative insults ‎by decreasing MDA and NO levels with a significant increase in the activity of ‎antioxidant enzymes (superoxide dismutase, catalase, and glutathione recycling enzymes peroxidase ‎and reductase) compared...
Schizophrenia (SCZ), a multifactorial neuropsychiatric disorder, is treated with inefficient anti... more Schizophrenia (SCZ), a multifactorial neuropsychiatric disorder, is treated with inefficient antipsychotics and linked to poor treatment outcomes. This study, therefore, investigated the combined administration of prodigiosin (PDG) and selenium (Na2SeO3) against SCZ induced by amphetamine (AMPH) in rats. Animals were allocated into four groups corresponding to their respective seven-day treatments: control, AMPH (2 mg/kg), PDG (300 mg/kg) + Na2SeO3 (2 mg/kg), and AMPH + PDG + Na2SeO3. The model group exhibited biochemical, molecular, and histopathological changes similar to those of the SCZ group. Contrastingly, co-administration of PDG and Na2SeO3 significantly increased the time for social interaction and decreased AChE and dopamine. It also downregulated the gene expression of NMDAR1 and restored neurotrophin (BDNF and NGF) levels. Further, PDG combined with Na2SeO3 improved the antioxidant defence of the hippocampus by boosting the activities of SOD, CAT, GPx, and GR. These find...
Since its emergence as a pandemic in March 2020, coronavirus disease (COVID-19) outcome has been ... more Since its emergence as a pandemic in March 2020, coronavirus disease (COVID-19) outcome has been exploredviaseveral predictive models, using specific clinical or biochemical parameters. In the current study, we developed an integrative non-linear predictive model of COVID-19 outcome, using clinical, biochemical, immunological, and radiological data of patients with different disease severities. Initially, the immunological signature of the disease was investigated through transcriptomics analysis of nasopharyngeal swab samples of patients with different COVID-19 severity versus control subjects (exploratory cohort, n=61), identifying significant differential expression of several cytokines. Accordingly, 24 cytokines were validated using a multiplex assay in the serum of COVID-19 patients and control subjects (validation cohort, n=77). Predictors of severity were Interleukin (IL)-10, Programmed Death-Ligand-1 (PDL-1), Tumor necrosis factors-α, absolute neutrophil count, C-reactive pr...
Iron is an integral part of haemoglobin molecule. Its deficiency leads to the commonest type of a... more Iron is an integral part of haemoglobin molecule. Its deficiency leads to the commonest type of anaemia in all geographic regions and racial groups. Its overload, if associated with presence of unbound iron in tissues, is characterized by tissue injury which may be severe enough to cause significant morbidity as a result of damage to heart, liver, pancreas, endocrines and almost any tissue. During the last decade, many poorly understood areas of iron homeostasis have been unraveled, especially pertaining to the influx of iron in the upper part of small intestine, its trafficking in the plasma, metabolism in the macrophage, red cell precursors & hepatocytes, and role of genes in iron metabolism.
Gastric ulcer (GU) is a lesion in the gastric mucosa associated with excessive oxidative damage, ... more Gastric ulcer (GU) is a lesion in the gastric mucosa associated with excessive oxidative damage, inflammatory response, apoptotic events, and irritation which may develop into cancer. However, medications commonly used in GU treatment cannot normalize gastric mucosa, while causing several adverse effects. Proanthocyanidins (PAs) are dietary flavonoids with numerous biological and pharmacological activities. In the current investigation, we studied the potential anti-ulcerative activity of PAs against acidified ethanol (HCl/ethanol)-caused gastric ulceration. Fifty male albino Wistar rats were allocated into five equal groups: control, HCl/ethanol (3 mL/kg), lansoprazole (LPZ, 30 mg/kg) + HCl/ethanol, and PAs (100 and 250 mg/kg) + HCl/ethanol. LPZ and PAs were applied one week before gastric ulcer induction. PAs pretreatment notably reduced gastric mucosal macroscopic and microscopic pathological changes in a dose-dependent manner. Additionally, PAs activated the innate antioxidant molecules including glutathione and its derived antioxidants (glutathione peroxidase and glutathione reductase), along with superoxide dismutase and catalase, while attenuating pro-oxidant formation, including malondialdehyde and nitric oxide. Interestingly, PAs supplementation at a higher dose suppressed gastric inflammatory and apoptotic responses, as demonstrated by the reduced levels of interleukin-1β, interleukin-6, tumor necrosis factor alpha, high-mobility group box 1, cyclooxygenase 2, prostaglandin E2, nuclear factor kappa-B, Bcl-2-associated X protein, and caspase-3, while B cell lymphoma 2 was elevated. Hence, PAs could exhibit antiulcer activity by protecting gastric tissue from the development of oxidative damage, inflammatory responses, and apoptosis events associated with ulceration. PRACTICAL IMPLICATIONS: Gastric ulcer is a lesion in the gastric mucosal layer associated with excessive inflammatory response, apoptotic events, oxidative damage, and irritation, and may develop into cancer with about 5%-10% morbidity rate. However, medications commonly used in GU treatment cannot normalize gastric mucosa, while causing several adverse effects. Therefore, new therapeutic approaches are needed to treat or prevent gastric ulceration. Proanthocyanidins (PAs, condensed tannins) are dietary flavonoids found in abundance in different plant species, including their fruits, bark, and seeds. Due to their potent antioxidative activity, PAs have been applied to prevent or treat oxidative stress-related diseases, including cancer, as well as metabolic, neurodegenerative, cardiovascular, and inflammatory disorders. Here, we examine the potential therapeutic role of proanthocyanidins (PAs) against acidified ethanol-induced gastric ulcer in rats through evaluating oxidative challenge, inflammatory response, apoptotic events, and histopathological changes in the gastric tissue.
A large number of central venous catheters (CVC) are placed each year in the emergency room, oper... more A large number of central venous catheters (CVC) are placed each year in the emergency room, operation theatre and critical care units. Although rarely associated with life threatening complications, femoral CVC is known to have the highest incidence of mechanical complications. The femoral veins are frequently preferred when other access sites are exhausted or there is increased risk for complications such as with emergency access, coagulopathy, and in the uncooperative patient .Femoral line placement confirmation is not routine practice. We present our case 59 years old male, Known case of Diabetes ,liver cirrhosis and portal hypertension presented to Accident and Emergency with repeated hematemesis and melena 3 times. On arrival to hospital patient was drowsy and hallucinating. Two large bore venous cannula were inserted and due to his hemodynamic instability requiring vasopressor support, Femoral venous catheter was inserted because of his deranged coagulation profile, with good...
The NHS and Community Care reforms give increased emphasis to meeting the needs of patients as co... more The NHS and Community Care reforms give increased emphasis to meeting the needs of patients as consumers of services, but little is known about patients' perceptions of services. In this study, we obtained the views of patients attending a geriatric day hospital about community care services and professional support; their knowledge of services, perceived unmet needs and perceptions of benefit. Forty-seven patients with a mental status score above 7/10 who attended the day hospital in a four week period were interviewed using structured questionnaires for consumer opinion, modified for this population. Patients had poor knowledge of services, especially of those which support carers and of private sources of support. When informed about the availability and purpose of local services, they recognised few unmet needs on average, less than one per patient, nearly always a need for social services, especially other forms of day care. Patients' perceptions of benefit from services and professional support were highest for day hospital care itself (98% of maximum possible benefit). There could be scope for the development of social work case management programmes in geriatric day hospitals; the methods used in this study provide a model for obtaining consumer opinion.
Nutritional supplements have been commonly used in the poultry industry last few years. The study... more Nutritional supplements have been commonly used in the poultry industry last few years. The study aimed to investigate the epigenetic effects of adding vitamin E and organic selenium to the diet of broiler breeders Ross-308 on their progeny meat production performance. The treatments included the control group fed with a standard diet without supplementation (T1), T2 using a standard diet supplemented with 500 mg of vitamin E / kg, T3 using a standard diet supplemented with 0.5 mg of organic selenium (Availa powder) /kg, and T4 using a standard diet supplemented with a mixture of vitamin E and organic selenium in proportions 500 and 0.5 mg/kg respectively. The eggs were collected from each treatment to obtain the progeny reared for 35 periods, and measurements were recorded for meat production and carcass traits. The results showed that the treatments had significant epigenetic effects on body weight at hatching. Hence, T2 had a significantly heavier body weight than T1, while no si...
Nutrition supplementation in broiler breeder diets are necessary to provide the nutritional requi... more Nutrition supplementation in broiler breeder diets are necessary to provide the nutritional requirements for the optimal performance of the broiler breeder flock after significant genetic improvement of production performance. The study aimed to determine the effect of adding vitamin E and organic selenium to the diet of broiler breeder Rose 308 in the productive and reproductive traits. The experimental flock consist of  60 hens  and 10 cocks at 41 weeks of age. The birds divided into four groups for treatments application, and each treatment had three replicates (five hens per replication). The first treatment T1 fed a standard diet without addition (control) containing 15% crude protein and metabolic energy 2775 kilocalories / kg of diet, and T2 used a standard diet and 500 mg vitamin E / kg of diet supplementation, and T3 used a standard ration plus 0.5 mg of organic selenium (Availa powder) / kg of diet supplementation, and T4 used  a standard diet plus a mixture of vitamin E a...
Silver nanoparticles (AgNPs) are the most common nanomaterials in consumer products. Therefore, i... more Silver nanoparticles (AgNPs) are the most common nanomaterials in consumer products. Therefore, it ‎has been crucial to control AgNPs toxicological effects to improve their safety and increase the outcome of their applications. This work investigated the possible protective effect of thymoquinone (TQ) against ‎AgNPs-induced hepatic and renal cytotoxicity in rats. Serum markers of liver and kidney functions as ‎well as liver and kidney oxidative stress status, pro-inflammatory cytokines, apoptosis markers, and ‎histopathology were assessed. TQ reversed AgNPs-induced elevation in serum liver and kidney function markers, including aspartate transaminase, alanine transaminase, urea, and ‎creatinine. Moreover, TQ co-administration with AgNPs alleviates hepatic and renal oxidative insults ‎by decreasing MDA and NO levels with a significant increase in the activity of ‎antioxidant enzymes (superoxide dismutase, catalase, and glutathione recycling enzymes peroxidase ‎and reductase) compared...
Schizophrenia (SCZ), a multifactorial neuropsychiatric disorder, is treated with inefficient anti... more Schizophrenia (SCZ), a multifactorial neuropsychiatric disorder, is treated with inefficient antipsychotics and linked to poor treatment outcomes. This study, therefore, investigated the combined administration of prodigiosin (PDG) and selenium (Na2SeO3) against SCZ induced by amphetamine (AMPH) in rats. Animals were allocated into four groups corresponding to their respective seven-day treatments: control, AMPH (2 mg/kg), PDG (300 mg/kg) + Na2SeO3 (2 mg/kg), and AMPH + PDG + Na2SeO3. The model group exhibited biochemical, molecular, and histopathological changes similar to those of the SCZ group. Contrastingly, co-administration of PDG and Na2SeO3 significantly increased the time for social interaction and decreased AChE and dopamine. It also downregulated the gene expression of NMDAR1 and restored neurotrophin (BDNF and NGF) levels. Further, PDG combined with Na2SeO3 improved the antioxidant defence of the hippocampus by boosting the activities of SOD, CAT, GPx, and GR. These find...
Since its emergence as a pandemic in March 2020, coronavirus disease (COVID-19) outcome has been ... more Since its emergence as a pandemic in March 2020, coronavirus disease (COVID-19) outcome has been exploredviaseveral predictive models, using specific clinical or biochemical parameters. In the current study, we developed an integrative non-linear predictive model of COVID-19 outcome, using clinical, biochemical, immunological, and radiological data of patients with different disease severities. Initially, the immunological signature of the disease was investigated through transcriptomics analysis of nasopharyngeal swab samples of patients with different COVID-19 severity versus control subjects (exploratory cohort, n=61), identifying significant differential expression of several cytokines. Accordingly, 24 cytokines were validated using a multiplex assay in the serum of COVID-19 patients and control subjects (validation cohort, n=77). Predictors of severity were Interleukin (IL)-10, Programmed Death-Ligand-1 (PDL-1), Tumor necrosis factors-α, absolute neutrophil count, C-reactive pr...
Iron is an integral part of haemoglobin molecule. Its deficiency leads to the commonest type of a... more Iron is an integral part of haemoglobin molecule. Its deficiency leads to the commonest type of anaemia in all geographic regions and racial groups. Its overload, if associated with presence of unbound iron in tissues, is characterized by tissue injury which may be severe enough to cause significant morbidity as a result of damage to heart, liver, pancreas, endocrines and almost any tissue. During the last decade, many poorly understood areas of iron homeostasis have been unraveled, especially pertaining to the influx of iron in the upper part of small intestine, its trafficking in the plasma, metabolism in the macrophage, red cell precursors & hepatocytes, and role of genes in iron metabolism.
Gastric ulcer (GU) is a lesion in the gastric mucosa associated with excessive oxidative damage, ... more Gastric ulcer (GU) is a lesion in the gastric mucosa associated with excessive oxidative damage, inflammatory response, apoptotic events, and irritation which may develop into cancer. However, medications commonly used in GU treatment cannot normalize gastric mucosa, while causing several adverse effects. Proanthocyanidins (PAs) are dietary flavonoids with numerous biological and pharmacological activities. In the current investigation, we studied the potential anti-ulcerative activity of PAs against acidified ethanol (HCl/ethanol)-caused gastric ulceration. Fifty male albino Wistar rats were allocated into five equal groups: control, HCl/ethanol (3 mL/kg), lansoprazole (LPZ, 30 mg/kg) + HCl/ethanol, and PAs (100 and 250 mg/kg) + HCl/ethanol. LPZ and PAs were applied one week before gastric ulcer induction. PAs pretreatment notably reduced gastric mucosal macroscopic and microscopic pathological changes in a dose-dependent manner. Additionally, PAs activated the innate antioxidant molecules including glutathione and its derived antioxidants (glutathione peroxidase and glutathione reductase), along with superoxide dismutase and catalase, while attenuating pro-oxidant formation, including malondialdehyde and nitric oxide. Interestingly, PAs supplementation at a higher dose suppressed gastric inflammatory and apoptotic responses, as demonstrated by the reduced levels of interleukin-1β, interleukin-6, tumor necrosis factor alpha, high-mobility group box 1, cyclooxygenase 2, prostaglandin E2, nuclear factor kappa-B, Bcl-2-associated X protein, and caspase-3, while B cell lymphoma 2 was elevated. Hence, PAs could exhibit antiulcer activity by protecting gastric tissue from the development of oxidative damage, inflammatory responses, and apoptosis events associated with ulceration. PRACTICAL IMPLICATIONS: Gastric ulcer is a lesion in the gastric mucosal layer associated with excessive inflammatory response, apoptotic events, oxidative damage, and irritation, and may develop into cancer with about 5%-10% morbidity rate. However, medications commonly used in GU treatment cannot normalize gastric mucosa, while causing several adverse effects. Therefore, new therapeutic approaches are needed to treat or prevent gastric ulceration. Proanthocyanidins (PAs, condensed tannins) are dietary flavonoids found in abundance in different plant species, including their fruits, bark, and seeds. Due to their potent antioxidative activity, PAs have been applied to prevent or treat oxidative stress-related diseases, including cancer, as well as metabolic, neurodegenerative, cardiovascular, and inflammatory disorders. Here, we examine the potential therapeutic role of proanthocyanidins (PAs) against acidified ethanol-induced gastric ulcer in rats through evaluating oxidative challenge, inflammatory response, apoptotic events, and histopathological changes in the gastric tissue.
A large number of central venous catheters (CVC) are placed each year in the emergency room, oper... more A large number of central venous catheters (CVC) are placed each year in the emergency room, operation theatre and critical care units. Although rarely associated with life threatening complications, femoral CVC is known to have the highest incidence of mechanical complications. The femoral veins are frequently preferred when other access sites are exhausted or there is increased risk for complications such as with emergency access, coagulopathy, and in the uncooperative patient .Femoral line placement confirmation is not routine practice. We present our case 59 years old male, Known case of Diabetes ,liver cirrhosis and portal hypertension presented to Accident and Emergency with repeated hematemesis and melena 3 times. On arrival to hospital patient was drowsy and hallucinating. Two large bore venous cannula were inserted and due to his hemodynamic instability requiring vasopressor support, Femoral venous catheter was inserted because of his deranged coagulation profile, with good...
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