The purpose of this study was to describe the clinical, hematologic, gross, histopathologic and t... more The purpose of this study was to describe the clinical, hematologic, gross, histopathologic and toxicologic findings and to report effective therapy application for aflatoxicosis in dogs, ascribed to the ingestion of moldy wet bread contaminated with aflatoxin. A prospective case series of 10 client-owned dogs from the same household developed toxicological signs after eating moldy bread treated with water that had been stored for an undetermined period, fully covered with a grey-green mold. All dogs exhibited vomiting followed by excessive salivation and hyperaesthesia. Among the surviving dogs (n = 7), three of them presented with diarrhea, depression, abdominal pain and two others showed icterus. One of the dead dogs was found on the initial referral. Two others were dead following initial diagnosis and prior to therapy application. The most common gross findings in the dogs were generalized icterus, mucosal or submucosal edema and petechial, to ecchymotic hemorrhages in the orga...
Levels of five heavy metals [copper (Cu), lead (Pb), cadmium (Cd), chromium (Cr) and nickel (Ni)]... more Levels of five heavy metals [copper (Cu), lead (Pb), cadmium (Cd), chromium (Cr) and nickel (Ni)] were evaluated in liver and muscle tissues of fish (Mugil auratus) collected from the Black Sea at Sinop-Icliman, Turkey. Sampling and analysis methods are described. Variations of heavy metal concentrations with seasons are discussed. Cr and Ni concentrations were below the limits of detection ( /0.05 and 0.1 mg/g dry weight) in all tissues and seasons. Cu, Pb and Cd were detected within these limits, as mg/kg dry weight, in liver tissue: 0.49 / 1.30, 0.60 /1.21 and 0.15 /0.50, and in muscle tissue: 0.30 /1.00, 0.57 /1.12 and 0.10 /0.40, respectively. Cu, Pb and Cd concentrations in these tissues were elevated and the highest heavy metal concentrations were found in the liver. While Cu, Pb and Cd concentrations were highest in fish tissues collected in August 2000, the lowest concen-trations of these metals were observed in fish tissues collected in May 2000. Pb had the highest level o...
ABSTRACT. This study was conducted to investigate the prophylactic effects of carnitine against c... more ABSTRACT. This study was conducted to investigate the prophylactic effects of carnitine against contrast-induced nephropathy (CIN) and its relation to oxidant/antioxidant status in kidney, liver, heart, spleen and lung tissues in a CIN rat model. Twenty-eight adult male Wistar rats were divided into 4 groups, the control, contrast media (CM), carnitine and contrast media+carnitine (CM+carnitine) groups. Animals were placed in individual metabolism cages, and on the 2nd day, rats were deprived of water for 24 hr. On the 3rd day, contrast media were admin-istered to groups CM and CM+carnitine. L-carnitine was administered on days 2, 3 and 4. Histopathological changes were evaluated in the right kidney after euthanization. Superoxide dismutase (SOD) and catalase (CAT) activities and glutathione (GSH) and malondialdehyde (MDA) levels were measured in renal, liver, heart, spleen and lung tissues. The SOD activities in the renal (P<0.05), liver (P<0.001) and spleen (P<0.05) tissu...
In this study, nikethamide (N) and dyprophylline (D), which are thought to improve the possibilit... more In this study, nikethamide (N) and dyprophylline (D), which are thought to improve the possibility of survival and enhance the pharmacodynamic effects on several haemodynamic parameters, were evaluated in respiratory deficient animals. For this purpose, 32 mongrel dogs aged 2-4 years were randomly divided into four equal groups. The drugs were administered intravenously to the dogs, following respiratoric suppression, which was formed by the administration of xylazine-thiopental sodium and restriction of oxygen. Haemodynamic measurements were conducted before, at the time of application (20 mg/kg N, 20 mg/kg D, 20 mg/kg N + 10 mg/kg D and 20 mg/kg N + 20 mg/kg D) and at 5, 15, 30, 45 and 60 min after drug administration. Haemodynamic parameters such as heart rate were monitored by ECG; systolic, diastolic and mean arterial blood pressure were determined by a direct method and cardiac output was determined by the thermodilution technique. Consequently, it was shown that the 20 mg/kg ...
Journal of Trace Elements in Medicine and Biology, 2020
This study was aimed to determine the effects of boric acid on oxidative stress, testicular tissu... more This study was aimed to determine the effects of boric acid on oxidative stress, testicular tissue and spermatozoon DNA. Experiments were performed with Swiss Albino mice divided equally into two groups based on the tratment period: one for 4 and the other for 6-week duration. These groups were further divided into subgroups as Control and those administered daily at oral doses of 115 mg/kg, 250 mg/kg and 450 mg/kg of boric acid. Then, testicular tissue were examined postmortem and analyzed using ex-vivo biochemical tools for oxidative stress, spermatozoon membrane integrity, sperm motility and live cell rate (%). In both 4 and 6-week groups, v. seminalis weight, membrane integrity, motility, live cells and GSH levels exhibited a decreasing trent compared to the controls. In addition, 6-week group had a decrease in SOD level. MDA level was higher in controls in both 4 and 6-week groups. Spermatozoon DNA was intact in the 4-week group, but damaged in the 6-week group, and the degree of the damage dependent on the administered dose. Boric acid induces oxidative stress in testicular tissue, and its long-term application (only 6 weeks) caused damage in spermatozoon DNA.
The purpose of this study was to describe the clinical, hematologic, gross, histopathologic and t... more The purpose of this study was to describe the clinical, hematologic, gross, histopathologic and toxicologic findings and to report effective therapy application for aflatoxicosis in dogs, ascribed to the ingestion of moldy wet bread contaminated with aflatoxin. A prospective case series of 10 client-owned dogs from the same household developed toxicological signs after eating moldy bread treated with water that had been stored for an undetermined period, fully covered with a grey-green mold. All dogs exhibited vomiting followed by excessive salivation and hyperaesthesia. Among the surviving dogs (n = 7), three of them presented with diarrhea, depression, abdominal pain and two others showed icterus. One of the dead dogs was found on the initial referral. Two others were dead following initial diagnosis and prior to therapy application. The most common gross findings in the dogs were generalized icterus, mucosal or submucosal edema and petechial, to ecchymotic hemorrhages in the orga...
Levels of five heavy metals [copper (Cu), lead (Pb), cadmium (Cd), chromium (Cr) and nickel (Ni)]... more Levels of five heavy metals [copper (Cu), lead (Pb), cadmium (Cd), chromium (Cr) and nickel (Ni)] were evaluated in liver and muscle tissues of fish (Mugil auratus) collected from the Black Sea at Sinop-Icliman, Turkey. Sampling and analysis methods are described. Variations of heavy metal concentrations with seasons are discussed. Cr and Ni concentrations were below the limits of detection ( /0.05 and 0.1 mg/g dry weight) in all tissues and seasons. Cu, Pb and Cd were detected within these limits, as mg/kg dry weight, in liver tissue: 0.49 / 1.30, 0.60 /1.21 and 0.15 /0.50, and in muscle tissue: 0.30 /1.00, 0.57 /1.12 and 0.10 /0.40, respectively. Cu, Pb and Cd concentrations in these tissues were elevated and the highest heavy metal concentrations were found in the liver. While Cu, Pb and Cd concentrations were highest in fish tissues collected in August 2000, the lowest concen-trations of these metals were observed in fish tissues collected in May 2000. Pb had the highest level o...
ABSTRACT. This study was conducted to investigate the prophylactic effects of carnitine against c... more ABSTRACT. This study was conducted to investigate the prophylactic effects of carnitine against contrast-induced nephropathy (CIN) and its relation to oxidant/antioxidant status in kidney, liver, heart, spleen and lung tissues in a CIN rat model. Twenty-eight adult male Wistar rats were divided into 4 groups, the control, contrast media (CM), carnitine and contrast media+carnitine (CM+carnitine) groups. Animals were placed in individual metabolism cages, and on the 2nd day, rats were deprived of water for 24 hr. On the 3rd day, contrast media were admin-istered to groups CM and CM+carnitine. L-carnitine was administered on days 2, 3 and 4. Histopathological changes were evaluated in the right kidney after euthanization. Superoxide dismutase (SOD) and catalase (CAT) activities and glutathione (GSH) and malondialdehyde (MDA) levels were measured in renal, liver, heart, spleen and lung tissues. The SOD activities in the renal (P<0.05), liver (P<0.001) and spleen (P<0.05) tissu...
In this study, nikethamide (N) and dyprophylline (D), which are thought to improve the possibilit... more In this study, nikethamide (N) and dyprophylline (D), which are thought to improve the possibility of survival and enhance the pharmacodynamic effects on several haemodynamic parameters, were evaluated in respiratory deficient animals. For this purpose, 32 mongrel dogs aged 2-4 years were randomly divided into four equal groups. The drugs were administered intravenously to the dogs, following respiratoric suppression, which was formed by the administration of xylazine-thiopental sodium and restriction of oxygen. Haemodynamic measurements were conducted before, at the time of application (20 mg/kg N, 20 mg/kg D, 20 mg/kg N + 10 mg/kg D and 20 mg/kg N + 20 mg/kg D) and at 5, 15, 30, 45 and 60 min after drug administration. Haemodynamic parameters such as heart rate were monitored by ECG; systolic, diastolic and mean arterial blood pressure were determined by a direct method and cardiac output was determined by the thermodilution technique. Consequently, it was shown that the 20 mg/kg ...
Journal of Trace Elements in Medicine and Biology, 2020
This study was aimed to determine the effects of boric acid on oxidative stress, testicular tissu... more This study was aimed to determine the effects of boric acid on oxidative stress, testicular tissue and spermatozoon DNA. Experiments were performed with Swiss Albino mice divided equally into two groups based on the tratment period: one for 4 and the other for 6-week duration. These groups were further divided into subgroups as Control and those administered daily at oral doses of 115 mg/kg, 250 mg/kg and 450 mg/kg of boric acid. Then, testicular tissue were examined postmortem and analyzed using ex-vivo biochemical tools for oxidative stress, spermatozoon membrane integrity, sperm motility and live cell rate (%). In both 4 and 6-week groups, v. seminalis weight, membrane integrity, motility, live cells and GSH levels exhibited a decreasing trent compared to the controls. In addition, 6-week group had a decrease in SOD level. MDA level was higher in controls in both 4 and 6-week groups. Spermatozoon DNA was intact in the 4-week group, but damaged in the 6-week group, and the degree of the damage dependent on the administered dose. Boric acid induces oxidative stress in testicular tissue, and its long-term application (only 6 weeks) caused damage in spermatozoon DNA.
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