Papers by Jennifer Weidman
<b>Copyright information:</b>Taken from "Maternal Genistein Alters Coat Color an... more <b>Copyright information:</b>Taken from "Maternal Genistein Alters Coat Color and Protects Mouse Offspring from Obesity by Modifying the Fetal Epigenome"Environmental Health Perspectives 2006;114(4):567-572.Published online 26 Jan 2006PMCID:PMC1440782.This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI. () Coat-color distribution of / offspring born to 15 unsupplemented and 12 genistein-supplemented litters. () Genomic sequence containing nine CpG sites located between the cryptic promoter and the IAP promoter (blue arrow in ) at the 5′ end of the contraoriented IAP. CpG sites 1–9 are numbered and marked by gray boxes. () Box plots representing the percentage of cells methylated at sites 4–9 in unsupplemented ( = 52) and genistein-supplemented ( = 44) / offspring. Ends of the boxes indicate the interquartile range representing the 25th to 75th percentiles of the data; horizontal lines within each box indicate median; and dashed horizontal lines represent average percent methylation of CpG sites 4–9 according to coat-color phenotype.
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<b>Copyright information:</b>Taken from "Maternal Genistein Alters Coat Color an... more <b>Copyright information:</b>Taken from "Maternal Genistein Alters Coat Color and Protects Mouse Offspring from Obesity by Modifying the Fetal Epigenome"Environmental Health Perspectives 2006;114(4):567-572.Published online 26 Jan 2006PMCID:PMC1440782.This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI. Significant weight differences among coat-color classes start at week 25 and continue through adulthood. Pseudoagouti animals exhibit normal body weight compared with overweight yellow, slightly mottled, mottled, and heavily mottled animals due to hyper-methylation in the IAP region, which shuts off ectopic transcription. By shifting the offspring population coat-color distribution toward brown pseudoagouti animals, genistein supplementation significantly increases the incidence of normal-body-weight animals.
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<b>Copyright information:</b>Taken from "Maternal Genistein Alters Coat Color an... more <b>Copyright information:</b>Taken from "Maternal Genistein Alters Coat Color and Protects Mouse Offspring from Obesity by Modifying the Fetal Epigenome"Environmental Health Perspectives 2006;114(4):567-572.Published online 26 Jan 2006PMCID:PMC1440782.This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI. Abbreviations: B, brain; K, kidney; L, liver; T, tail. Average methylation across CpG sites 1–9 in day 150 tissues derived from ectodermal (B and T), mesodermal (K), and endodermal (L) tissues from five genistein-supplemented / animals representing the five coat-color phenotypes is correlated with that in day 21 tail tissue (Pearson's &gt; 0.9 and &lt; 0.05 for each correlation).
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<b>Copyright information:</b>Taken from "Maternal Genistein Alters Coat Color an... more <b>Copyright information:</b>Taken from "Maternal Genistein Alters Coat Color and Protects Mouse Offspring from Obesity by Modifying the Fetal Epigenome"Environmental Health Perspectives 2006;114(4):567-572.Published online 26 Jan 2006PMCID:PMC1440782.This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI. () CpG methylation variable specified as regional methylation of CpG sites 4–9. Genistein diet significantly influences coat color (top); however, the relationship is reduced when regional methylation is included in the regression model (bottom). () CpG methylation variable specified as individual CpG site 4. When CpG site 4 methylation is included in the model (bottom), the direct effect of diet on coat color is abrogated, indicating that methylation at site 4 plays a strong role in mediating the genistein effect on coat color.
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In 2008, Environmental Health Perspectives (EHP) established the Paper of the Year Award as a mea... more In 2008, Environmental Health Perspectives (EHP) established the Paper of the Year Award as a means of recognizing high-impact papers published in the journal (Tilson 2008). Originally, the Paper of the Year was selected on the basis of citations received over the preceding 60 months. Earlier this year EHP announced that it would be recognizing two papers each year (Tilson 2011). The EHP Classic Paper of the year will be the research article, commentary, or review article that is the most highly cited paper over the preceding 60 months. The winner of the 2011 EHP Classic Paper of the Year
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Genistein, the major phytoestrogen in soy, is linked to diminished female reproductive performanc... more Genistein, the major phytoestrogen in soy, is linked to diminished female reproductive performance and to cancer chemoprevention and decreased adipose deposition. Dietary genistein may also play a role in the decreased incidence of cancer in Asians compared with Westerners, as well as increased cancer incidence in Asians immigrating to the United States. Here, we report that maternal dietary genistein supplementation of mice during gestation, at levels comparable with humans consuming high-soy diets, shifted the coat color of heterozygous viable yellow agouti (A vy /a) offspring toward pseudoagouti. This marked phenotypic change was significantly associated with increased methylation of six cytosine–guanine sites in a retrotransposon upstream of the transcription start site of the Agouti gene. The extent of this DNA methylation was similar in endodermal, mesodermal, and ectodermal tissues, indicating that genistein acts during early embryonic development. Moreover, this genistein-in...
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We report a high-quality draft of the genome sequence of the grey, short-tailed opossum (Monodelp... more We report a high-quality draft of the genome sequence of the grey, short-tailed opossum (Monodelphis domestica). As the first metatherian ('marsupial') species to be sequenced, the opossum provides a unique perspective on the organization and evolution of mammalian genomes. Distinctive features of the opossum chromosomes provide support for recent theories about genome evolution and function, including a strong influence of biased gene conversion on nucleotide sequence composition, and a relationship between chromosomal characteristics and X chromosome inactivation. Comparison of opossum and eutherian genomes also reveals a sharp difference in evolutionary innovation between protein-coding and non-coding functional elements. True innovation in protein-coding genes seems to be relatively rare, with lineage-specific differences being largely due to diversification and rapid turnover in gene families involved in environmental interactions. In contrast, about 20% of eutherian ...
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The Cancer Journal, 2007
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Reproductive Toxicology, 2007
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Pediatric Research, 2007
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Journal of Dental Research, 2007
Maternal oral infection, caused by bacteria such as C. rectus or P. gingivalis, has been implicat... more Maternal oral infection, caused by bacteria such as C. rectus or P. gingivalis, has been implicated as a potential source of placental and fetal infection and inflammatory challenge, which increases the relative risk for pre-term delivery and growth restriction. Intra-uterine growth restriction has also been reported in various animal models infected with oral organisms. Analyzing placental tissues of infected growth-restricted mice, we found down-regulation of the imprinted Igf2 gene. Epigenetic modification of imprinted genes via changes in DNA methylation plays a critical role in fetal growth and development programming. Here, we assessed whether C. rectus infection mediates changes in the murine placenta Igf2 methylation patterns. We found that infection induced hypermethylation in the promoter region-P0 of the Igf2 gene. This novel finding, correlating infection with epigenetic alterations, provides a mechanism linking environmental signals to placental phenotype, with conseque...
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Pediatric …, 2007
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Genome Research, 2006
Muscular hypertrophy in callipyge sheep results from a single nucleotide substitution located in ... more Muscular hypertrophy in callipyge sheep results from a single nucleotide substitution located in the genomic interval between the imprinted Delta, Drosophila, Homolog-like 1 (DLK1) and Maternally Expressed Gene 3 (MEG3). The mechanism linking the mutation to muscle hypertrophy is unclear but involves DLK1 overexpression. The mutation is contained within CLPG1 transcripts produced from this region. Herein we show that CLPG1 is expressed prenatally in the hypertrophy-responsive longissimus dorsi muscle by all four possible genotypes, but postnatal expression is restricted to sheep carrying the mutation. Surprisingly, the mutation results in nonimprinted monoallelic transcription of CLPG1 from only the mutated allele in adult sheep, whereas it is expressed biallelically during prenatal development. We further demonstrate that local CpG methylation is altered by the presence of the mutation in longissimus dorsi of postnatal sheep. For 10 CpG sites flanking the mutation, methylation is s...
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Genome Research, 2004
Genomic imprinting results in monoallelic gene transcription that is directed by cis-acting regul... more Genomic imprinting results in monoallelic gene transcription that is directed by cis-acting regulatory elements epigenetically marked in a parent-of-origin-dependent manner. We performed phylogenetic sequence and epigenetic comparisons of IGF2 between the nonimprinted platypus (Ornithorhynchus anatinus) and imprinted opossum (Didelphis virginiana), mouse (Mus musculus), and human (Homo sapiens) to determine if their divergent imprint status would reflect differences in the conservation of genomic elements important in the regulation of imprinting. We report herein that IGF2 imprinting does not correlate evolutionarily with differential intragenic methylation, nor is it associated with motif 13, a reported IGF2-specific “imprint signature” located in the coding region. Instead, IGF2 imprinting is strongly associated with both the lack of short interspersed transposable elements (SINEs) and an intragenic conserved inverted repeat that contains candidate CTCF-binding sites, a role not ...
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Epigenetics, 2006
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Environmental Health Perspectives, 2006
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Papers by Jennifer Weidman