Papers by Jan Carlo Delorenzi
Food and Nutrition Sciences
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Journal of Cardiovascular Development and Disease
Depression is one of the world’s most common and mentally disabling illnesses. Post-partum depres... more Depression is one of the world’s most common and mentally disabling illnesses. Post-partum depression is a subtype of depression that affects one in seven women worldwide. Successful pharmacological treatment must consider the consequences for both, since the mother–child bond is fundamental for the well-being of both mother and infant as well as the general development of the newborn. Changes in maternal physiology and/or behavior can significantly influence the development of breastfed infants. Ketamine has been extensively studied for use as an antidepressant due to its mixed mechanisms of action. Safety and efficacy studies in the cardiovascular and urinary systems of a lactating postpartum depression animal model are essential for contributing toward ketamine’s clinical use in the respective patient population. Thus, this project aimed to study the implications of postpartum maternal exposure to ketamine during lactation on the cardiovascular system of female rats submitted to ...
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African journal of pharmacy and pharmacology
The knowledge of pharmacological activity is mainly derived from the use that the population make... more The knowledge of pharmacological activity is mainly derived from the use that the population makes of plants. Rue (Ruta graveolens L.) is popularly used with a degree of mysticism due to its anti-inflammatory, healing, sedative and antispasmodic characteristics. In an attempt to confirm the well-known analgesic effects, the present study evaluated Rue extracts in animal models. Two organic extracts were produced and orally administered to mice, approximately 30 min before the tail immersion test in warm water (55 ± 0.5°C). The results reveal a small chronic analgesic effect and a high effect in acute essay (62.1% of pain inhibition) especially observed in the hexane extract, supporting the hypothesis of the use of this plant as having analgesic activity. However, the reports of the population about its analgesic activity should be caused also by its anti-inflammatory characteristics and the presence of compounds related in literature as analgesics. Further experiments should be done...
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Phytochemistry, 2011
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Planta Medica, 2010
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Planta Medica, 2010
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Planta Medica, 2010
Leishmaniasis is a major worldwide health problem, with around 12 million people infected and 600... more Leishmaniasis is a major worldwide health problem, with around 12 million people infected and 600 thousand new cases appearing each year. In Brazil, 30 thousand new cases appear annually only in the Northeast region. Pentavalent antimonals are the first line treatment for leishmaniasis. Disadvantages such as costs, long-term treatment, side effects and low efficacy against many strains have been reported. Although great efforts had done along the last century to develop new drugs for leishmaniasis treatment, a drug with high efficacy and low side effects is still need. Among all strategies used to develop new agents against leishmaniasis, the research of natural products produced good results. This work investigated the leishmanicidal activity of oleanolic acid (OA), a natural triterpene found in a great variety of plants against promastigotes forms of L. braziliensis and L. chagasi. Promastigotes were incubated in the presence of different concentrations of OA, which was added only once to the cultures. After 3 days at 26°C, parasite survival was estimated by counting viable or motile forms. OA exhibited a good anti-promastigote activity both for L. braziliensis and L. chagasi, reducing parasite survival in 75 and 94%, respectively, when we used 50µg/ml of the drug. DMSO 1% was used as solvent control. These results suggest that L. braziliensis is less susceptive than L. chagasi. No toxicity to the macrophages was observed after the treatment with OA, as measured by their spreading and adherence to glass surface. These results reinforce that OA could be a strong candidate for an antileishmanial drug. Acknowledgements: Hebron Farmaceutica, MackPesquisa, PIBIC/Mackenzie, CNPq, FAPERJ
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Toxics, May 23, 2022
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Revista Em Extensão, 2013
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- Avaliar a atividade anti-promastigota contra Leishmania amazonensis Leishmania brasiliensis e L... more - Avaliar a atividade anti-promastigota contra Leishmania amazonensis Leishmania brasiliensis e Leishmania chagasi, in vitro, de Ibogamina, Tabersonina e 12-metoxi-Nb-Metilvoachalotina; - Avaliar a atividade anti-amastigota contra Leishmania amazonensis, Leishmania brasiliensis e Leishmania chagasi, in vitro, de Ibogamina, Tabersonina e 12-metoxi-Nb-Metilvoachalotina; - Avaliar a citotoxicidade dos referidos farmacos contra macrofagos peritoneais de camundongo, estabelecendo uma ordem crescente de citotoxicidade; - Avaliar a atividade Leishmanicida, in vivo, em modelo de infeccao tegumentar dos farmacos; Proceder a avaliacoes in silico do tipo ADMET (Absorcao, Distribuicao, Metabolismo, Excrecao e Toxicidade) dos farmacos em estudo
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Medical research archives, 2018
Antiphospholipid syndrome (APS) is characterized by thrombosis and/or recurrent miscarriage and t... more Antiphospholipid syndrome (APS) is characterized by thrombosis and/or recurrent miscarriage and the presence of persistent antiphospholipid antibodies (aPL). APS during pregnanvy represents an increased risk of miscarriage and thrombotic events for the woman and fetus. The treatment of APS is based on lifetime anticoagulation therapy, using aspirin which may be combined with heparin. However, many reports show that women can be refractory to this treatment. In spite of attempts to develop new therapies, the treatment outcomes for APS in pregnancy remain poor. The development of new therapeutic modalities is needed to treat and/or prevent thrombosis in pregnant patients with APS and protect the fetus.
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Parasitology International, 2016
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Experimental Diabetes Research, 2012
We evaluated cardiac autonomic modulation by heart rate (HRV), and arterial pressure variability ... more We evaluated cardiac autonomic modulation by heart rate (HRV), and arterial pressure variability (APV), and metabolic response in streptozotocin diabetic rats treated with green tea. Male Wistar rats were separated in groups: control, drinking tap water (C), green tea-treated (GT) group, diabetic, drinking tap water (D), and diabetic, treated with green tea (DGT). Kidney mass was greater in D and DGT than in C and GT, but reduced in DGT compared to D. Green tea prevented the increase in creatinine clearance and reduced hyperglycemia in DGT compared to D. Arterial pressure was increased in GT and decreased in D compared to C. HRV was reduced in D compared with all groups. APV was decreased in D compared to C and recovery in DGT. Sympathetic modulation of APV was decreased in D compared with all groups. Green tea reduced hyperglycemia, prevented renal injury and autonomic dysfunction, suggesting reduced cardiovascular risk and target organ damage in diabetes.
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Planta Medica, 2010
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Parasitology International, 2010
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Antimicrobial Agents and Chemotherapy, 2002
In previous studies, we demonstrated the leishmanicide effect of coronaridine, a natural indole a... more In previous studies, we demonstrated the leishmanicide effect of coronaridine, a natural indole alkaloid isolated from stem bark of Peschiera australis (Delorenzi et al., Antimicrob. Agents Chemother. 45: 1349-1354, 2001). In this study we show the leishmanicidal effect of the synthetic coronaridine and its racemic 18-methoxylated analog, 18-methoxycoronaridine. Both alkaloids revealed a potent leishmanicide effect against Leishmania amazonensis , a causative agent of cutaneous and diffuse cutaneous leishmaniasis in the New World. Despite their potent leishmanicide effect, both alkaloids were neither toxic to murine macrophages nor did they modulate their oxidative or cytokine production responses.
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Antimicrobial Agents and Chemotherapy, 2001
In this study, we show the leishmanicidal effects of a chloroform fraction (CLF) and a purified i... more In this study, we show the leishmanicidal effects of a chloroform fraction (CLF) and a purified indole alkaloid obtained from crude stem extract of Peschiera australis against Leishmania amazonensis , a causative agent of cutaneous leishmaniasis in the New World. In a bioassay-guided chemical fractionation, the leishmanicidal activity in CLF completely and irreversibly inhibited promastigote growth. This fraction was also active against amastigotes in infected murine macrophages. Chemical analysis of CLF identified an iboga-type indole alkaloid coronaridine as one of its major compounds. Coronaridine showed potent antileishmanial activity, inhibiting promastigote and amastigote growth. Promastigotes and amastigotes treated with CLF or coronaridine showed pronounced alterations in their mitochondria as assessed by transmission electron microscopy.
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Papers by Jan Carlo Delorenzi