Papers by Humberto González
Hematology and cell therapy, 1999
Since 1990 we have treated 60 patients with standard-dose fludarabine for chronic lymphocytic leu... more Since 1990 we have treated 60 patients with standard-dose fludarabine for chronic lymphocytic leukemia (B-CLL), on a compassionate basis. Three patients developed grade IV neurologic complications after treatment, with demyelination of white matter on magnetic resonance imaging (MRI) in patient # 1, diffuse demyelination, abnormal oligodendroglia and enlarged astrocytes at brain biopsy in patient no 2, and progressive multifocal leukoencephalitis (PML) with JC virus on brain biopsy in patient # 3. The neurotoxicity of fludarabine was often observed after administration of high doses (90-120 mg/m2). At standard doses (18-25 mg/m2) neurologic complications were observed in very few cases (0.2%). PML was observed in only 0.52% of patients with chronic lymphocytic leukemia (CLL), particularly those with advanced CLL. Our findings are consistent with the results of published studies and show an increase in neurologic complications in patients with advanced CLL treated with fludarabine. T...
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1995 IEEE Nuclear Science Symposium and Medical Imaging Conference Record, 1995
A test stand for the next generation of the Silicon Vertex Detector (SVX-II) of the Collider Dete... more A test stand for the next generation of the Silicon Vertex Detector (SVX-II) of the Collider Detector Facility (CDF) at Fermilab has been developed. It is capable of performing cosmic ray, beam, and laser pulsing tests on silicon strip detectors using the new generation of SVX chips. The test stand is composed of a SGI workstation, a VME CPU, the
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Small Ruminant Research, 1998
This study was conducted to investigate the effect of high (0.5 mg/kg) and low (1.0 mg) doses of ... more This study was conducted to investigate the effect of high (0.5 mg/kg) and low (1.0 mg) doses of naloxone on sexual behaviour, ovulation rate and blood plasma concentrations of oestradiol 17 β in Suffolk×Hampshire ewes induced into oestrus during the non-breeding season (May 1993). For this purpose, 60 ewes were allocated at random to four groups of 15 animals. Those
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Progress in Oceanography, 2007
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Vertical fluxes of particles have been estimated during the last decade in coastal and oceanic sy... more Vertical fluxes of particles have been estimated during the last decade in coastal and oceanic systems off central-southern Chile. Free-drifting, cylindrical sediment traps have been deployed below the mixing layer from coastal areas, while automatic, cone-shaped sediment traps have been anchored in deep oceanic areas. Vertical fluxes toward 2300 m depth off Coquimbo were dominated by calcium carbonate (~70 mg
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SPE Latin America Petroleum Engineering Conference, 1992
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Progress in Oceanography, 2007
Seasonal variations in diversity and biomass of diatoms, tintinnids, and dinoflagellates and the ... more Seasonal variations in diversity and biomass of diatoms, tintinnids, and dinoflagellates and the contribution of microplankton and faecal material to the vertical flux of particulates were investigated at one time series station T (station 18) between 2002 and 2005 and at a grid of stations during November 2004 in the coastal and oceanic area off Concepción (36°S), Chile. The variations
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Marine Ecology-progress Series, 2005
The feeding of 2 sympatric larval myctophids, Diogenichthys laternatus and Triphoturus mexicanus ... more The feeding of 2 sympatric larval myctophids, Diogenichthys laternatus and Triphoturus mexicanus aff. oculeus, was analyzed in an upwelling area off northern Chile (23° S, 71° W). Diel feeding period, feeding incidence, feeding selectivity and diet overlap was estimated under different environmental conditions: coastal and oceanic areas and 2 depth strata in summer and winter 1997. Analyses were based on
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Marine Ecology-progress Series, 2000
ABSTRACT A multi-disciplinary research program was conducted in the northern Humboldt Current Sys... more ABSTRACT A multi-disciplinary research program was conducted in the northern Humboldt Current System in a 80 x 80 nautical mile area off Antofagasta, northern Chile (23°S) on 3 occasions: before the 1997/98 El Nino event (January 1997), and during the onset and maximum periods of the event (July 1997 and January 1998, respectively). As a part of this program, the trophodynamic role of pelagic tunicates (salps and appendicularians), as well as the crustacean zooplankton, divided into 3 size classes (large- [euphausiids], medium- [large calanoid copepods] and small-size animals [small calanoid and cyclopoid copepods]) were assessed. One of the most conspicuous physical processes was the deepening of the thermocline during the El Nino event, which in turn led to suppression of nutrient enrichment by upwelling events and low chlorophyll a (chl a) concentrations in the study area. Chl a and particulate organic carbon (POC) values were higher near the coast, and coastal/oceanic gradients were greater in the case of chl a. High chl a (100 to 160 mg m -2) and POC (11 to 17 g m -2) concentrations were usually found associated with bays and/or capes within 40 nautical miles of the coast. In contrast, oceanic areas showed low concentrations throughout the study. Small calanoid and cyclopoid copepods represented only a minor fraction of the total crustacean zooplankton carbon (4 to 20%), although they often accounted for a relatively large portion of the total ingestion (26 to 68%) of the crustacean zooplankton community. Euphausiids represented a large fraction of total crustacean zooplankton carbon (28 to 73%), and accounted for between 5 and 61% of total crustacean zooplankton grazing. Ingestion rate as a percentage of body carbon was negatively correlated with animal size, varying between 4% in euphausiids (17 mm) and 123% in small calanoid copepods (0.8 to 1.7 mm). A comparison of estimated dally respiration rates and dally carbon ingestion rates indicated that ingestion of phytoplankton would have exceeded respiratory demands for both large and small calanoid copepods during all 3 sampling periods. In contrast, ingestion of phytoplankton failed to account for the respiratory needs of the euphausiids. This, together with microscopical observations, led to the conclusion that euphausiids utilised other sources of carbon such as detritus, micro- and mesozooplankton in addition to phytoplankton. Crustacean zooplankton showed a significant grazing impact, removing from 10 to 34% of primary production (PP). Salps of the species Salpa fusiformis were present in dense aggregates that could have removed up to 60% of PP during January 1997. On average, the grazing impact of this species was approximately one-half (16%) that of the whole crustacean zooplankton community combined (34%). We did not find any significant difference in zooplankton biomass between January 1997 (non-El Nino) and January 1998 (El Nino), with average biomasses of 24.6 and 21.4 mg dry wt m -3, respectively. There was, however, a shift in the size spectrum of crustacean zooplankton towards small-sized copepods between January 1997 (60 mg C m -2) and January 1998 (186 mg C m -2).
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Medicina Intensiva, 2010
To present the results of the first year of the functioning of a Cardiopulmonary Resuscitation (C... more To present the results of the first year of the functioning of a Cardiopulmonary Resuscitation (CPR) Hospital Plan and to describe the characteristics of the patients with cardiopulmonary arrest (CPA) in hospital units with no monitoring facilities (HU). An observational, prospective study in a cohort of patients who presented CPA during a one-year period. HU of a general hospital and as province reference. Patients admitted to an HU from May 2007 to May 2008 with CPA and treated according to a specific hospital CPA Program, organized in order to: (a) decentralize the CPR through the training of the nurse as the first responder capable of performing immediate CPR and early defibrillation (DF) (less than 4 min), (b) a specific phone number as hospital alarm of CPR and (c) maintenance of the CPR maneuvers by an early intervention Resuscitation Team (RT) (less than 8 min). Characteristics of patients, CPA episode and results according to the <Utstein style>. A total of 73 patients were included with activation of the CPA alarm, 8 of which were false alarms, with an average age of 70 years and 60% men. A total of 65% occurred in the medical area in patients with heart or respiratory failure, sepsis or septic shock. Initial heart rhythm of the patients attended was asystolic in 74% of the patients, ventricular fibrillation in 18% and electromechanical dissociation in 8%. The first attending person was the nurse in 79% of cases, CPR was always initiated in less than 1 min, DF in less than 2 min (92%) and RT in less than 8 min (96%). Fifty-five percent survived and 35% of the reanimated patients were discharged live from the hospital, 78% with good neurological outcomes. The CPR "Juan Ramón Jiménez" Hospital Program is an applicable and effective initiative in our setting.
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Marine Pollution Bulletin, 1990
Havana City, with a population of more than 2 million, is the most populated area of Cuba with a ... more Havana City, with a population of more than 2 million, is the most populated area of Cuba with a major industrial centre and maritime port. A mean of 233,000 m super(3) day of untreated mixed urban and industrial waste waters are discharged at Chivo Beach ...
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International Journal of Paediatric Dentistry, 2006
The purpose of this study was to compare the chemomechanical caries-removal system (Carisolv) wit... more The purpose of this study was to compare the chemomechanical caries-removal system (Carisolv) with high-speed excavation in cavitated occlusal caries of primary molars. Design and setting. The study was a randomized controlled, clinical trial in which the two techniques were compared in each subject. Participants were chosen from public schools, in Maracaibo County, Zulia State, Venezuela. The sample consisted of 80 primary molars selected from 40 children (mean age 7.7+/-0.7 years). Each patient had at least two contralateral primary molars with cavitated occlusal caries and approximately equal-size access to lesions. The outcome variables were: clinically complete caries removal, size of the opening of the cavity, volume of carious tissue removed, pain during caries removal, anaesthesia requested by the patient, caries-removal time, and behaviour and preference of patients. All treated molars were clinically caries free whichever caries-removal procedure was used. When Carisolv' was used the final cavity entrance sizes were smaller (P<0.001) and the estimated volume of tissue removed was less (P<0.001). The time taken for caries removal was three times longer (7.51+/-1.83 min, P<0.001). Some pain was reported by seven (17.5%) participants when Carisolv was used, compared with 16 (40%) when high-speed excavation was used (P<0.05). Using the Carisolv method there was a higher proportion of patients with positive behaviour (P<0.01), and 71.0% (P<0.05) preferred this treatment. Carisolv is an effective clinical alternative treatment for the removal of occlusal dentinal caries in cavitated primary molars; it is more conservative of dental tissue and appeared to be more comfortable for most patients, although the clinical time spent is longer than when using high-speed excavation.
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Gayana (Concepción), 2006
ABSTRACT Vertical fluxes of particles have been estimated during the last decade in coastal and o... more ABSTRACT Vertical fluxes of particles have been estimated during the last decade in coastal and oceanic systems off central-southern Chile. Free-drifting, cylindrical sediment traps have been deployed below the mixing layer from coastal areas, while automatic, cone-shaped sediment traps have been anchored in deep oceanic areas. Vertical fluxes toward 2300 m depth off Coquimbo were dominated by calcium carbonate (~70 mg m -2 d -1 ) instead of particulate organic carbon (POC ~7 mg m -2 d - 1 ), where foraminifers (Neogloboquadrina pachyderma) and faecal pellets of Euphausia mucronata and Oikopleura spp, played important roles as vehicles for carbonate and carbon, respectively. In coastal upwelling systems, (i. e. Concepción), the dominant vertical flux was POC, mainly driven by euphausiids faecal strings and diatoms of the genera Thalassiosira, Chaetoceros and Skeletonema. Bacterial degradation of exported POC towards deeper layer of the ocean seems not to be significantly affected by the oxic versus hypoxic levels of dissolved oxygen characteristics of different water masses.
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Revista Española de Geriatría y Gerontología, 2005
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Data came from a herd of Limousin cattle located at the north of México. Progeny (n=17 and n=24) ... more Data came from a herd of Limousin cattle located at the north of México. Progeny (n=17 and n=24) calves from heifers and mature cows, respectively of 41 of a total of 51dams involving inheritance of Limousin mated to Limousin sires (n=9) were used. The objective was to estimate heritability direct, and phenotypic parameters for weight at 365-d YWT, total feed
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Thirty three consecutive patients with chronic osteomyelitis and deficient soft tissue coverage t... more Thirty three consecutive patients with chronic osteomyelitis and deficient soft tissue coverage treated with a muscle flap from 1991-1998 were reviewed retro- spectively. Osteomyelitis was diagnosed by positive bone cultures and radio- graphic changes consistent with osteomy- elitis. Osteomyelitis was divided into local- ized <50% diameter : 24 patients and diffuse >50% diameter or infected non- union: 9 patients. The
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Tectonophysics, 1987
The Western Cordillera of Colombia was formed by intense alpine-type nappe-forming folding and th... more The Western Cordillera of Colombia was formed by intense alpine-type nappe-forming folding and thrusting. The Cretaceous (80120 Ma BP) tholeiitic material of the Western Cordilleran nappes has been obducted onto the Paleozoic and Precambrian polymetamorphic ...
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Genetic parameters for birth weight BW and calving difficulty CD were estimated in the progeny of... more Genetic parameters for birth weight BW and calving difficulty CD were estimated in the progeny of 53 Holstein heifers mated AI to Jersey sires (n=7), under a grazing system, and heat stress conditions, in a dairy herd located in a desertic region at the north west of Mexico. Data was analyzed by using least squares The analytical model included: dam, sex of the calf, and season of parturition as fixed effects; sire, sire x season parturition interaction and the residual as random. The average age of heifers and weight at first mating AFM were 17.39±2.03 month and 345 kg, respectively. Overall mean BW was 31.82±1.59. BW ranged 32.04 ±1.60 to 30.44 ±1.52 kg in male and female calves, respectively. Male calves were 5.25% heavier (P<0.05) than female calves. The average values of number of services per conception SPC and gestation length GL were 1.37± 0.07 and 270.71±9.40 and weight; 268.68± 5.37 and 272.59± 5.45 d for female and male calves, respectively. GL of Jersey x Holstein hei...
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Papers by Humberto González