Papers by Hitoshi Miyaoka
The Proceedings of the Annual Convention of the Japanese Psychological Association
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The Open Family Studies Journal
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Seishin Shinkeigaku Zasshi Psychiatria Et Neurologia Japonica, Feb 1, 2006
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The Kitasato Medical Journal, Sep 30, 2004
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J Interferon Cytokine Res, 2005
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Epilepsy research, Jul 1, 2016
A mouse model of epilepsy was generated by inducing status epilepticus (SE) for either 1.5 or 4.5... more A mouse model of epilepsy was generated by inducing status epilepticus (SE) for either 1.5 or 4.5h with pilocarpine to study anxiety-related behaviors, changes in the electroencephalogram of the cerebral cortex and hippocampus, and expression of hippocampal proteins. The viability and rate of success of SE induction were high in C57BL/6N mice but not in C57BL/6J mice. C57BL/6N mice were immotile during the first 2days after SE; however, by the third day, most mice were recovered and exhibited strong anxiety-related behaviors in response to the light/dark preference test and open field test. There was a striking difference in the temporal appearance of anxiety-related behavior between the two SE durations: 1.5h SE mice exhibited strong anxiety-related behavior 3days after SE that gradually attenuated over the next few weeks, whereas 4.5h SE mice exhibited strong anxiety-related behavior 3days after SE that persisted even at nearly 1year after SE. Mice receiving both SE durations exhi...
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Nippon Rinsho Japanese Journal of Clinical Medicine, Oct 1, 2013
In Japan, the elderly patients generally account for high percentages of both inpatients and outp... more In Japan, the elderly patients generally account for high percentages of both inpatients and outpatients. As aging of the population accelerates, it will become increasingly important to properly detect, assess and intervene for psychiatric symptoms of the elderly patients to establish differential diagnoses. Thus, we must assess all existing psychiatric symptoms by keeping in mind the brain/physical conditions and social circumstances of the elderly patients and considering not just their complaints but also objective information from other organizations/services. In doing so, particular emphasis should be placed on assessing consciousness. Decreased alertness should not be dismissed as "old age". Medical professionals and caregivers must carefully assess psychiatric symptoms in the elderly patients while respecting their self-esteem.
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Seizure, 2016
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Neurosci Res, 2011
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Journal of Psychiatric Research, Jul 1, 2000
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Int Clin Psychopharmacol, 1999
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Journal of Interferon Cytokine Research, May 1, 2005
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Circulation, Nov 25, 2014
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Cell Mol Neurobiol, 2003
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Journal of Psychiatry Neuroscience Jpn, Jul 1, 2003
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The Kitasato Medical Journal, Mar 1, 2008
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International Clinical Psychopharmacology, Dec 1, 1995
This report describes a case of encephalopathy developed in the course of amitriptyline therapy, ... more This report describes a case of encephalopathy developed in the course of amitriptyline therapy, during a remission of unipolar depression. This patient could have been diagnosed as having either neuroleptic malignant syndrome (NMS) or serotonin syndrome (SS). The major determinant of the symptoms may have been dopamine/serotonin imbalance in the central nervous system. The NMS-like encephalopathy that develops in association with the use of antidepressants indicates that NMS and SS are spectrum disorders induced by drugs with both antidopaminergic and serotonergic effects.
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Seishin Shinkeigaku Zasshi Psychiatria Et Neurologia Japonica, 2014
In May 2011, the Japanese Society of Psychiatry and Neurology released their Guidelines on Confli... more In May 2011, the Japanese Society of Psychiatry and Neurology released their Guidelines on Conflict of Interest (COI) in Clinical Research and detailed regulations. These guidelines cover clinical research, although each committee of the society may have a policy to cover basic research as well as clinical research. The COI Committee implemented the guidelines, including a one-year trial period. According to the guidelines, members of the society have to disclose their COIs at the time of presentations, manuscript submissions, and publications; the board and committees members have to submit their COIs to the president of the society. During the trial period, the latter was limited to the four committees involved in the development of the guidelines: Conflict of Interest; Pharmaceutical Affairs; Research Ethics; and Editorial Committees. The COI Committee reviewed the COIs submitted by the board and committee members. The COI Committee found that, among the 382 board and committee members, 298 were without COI; 31 COIs were regarded by one committee member as not necessary to be circulated to all the attending members (total of these 2 categories: 329, 87%); 31 COIs (8%) were regarded as necessary to be circulated; and 18 cases (4.7%) were problematic: not submitted or explicit rejection of submission. Considering the seriousness of scientific misconduct by a researcher in another disease area who resigned his professorship and is now under investigation, we should further discuss the implementation of our COI guidelines.
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international journal of stomatology & occlusion medicine, 2011
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Seishin Shinkeigaku Zasshi Psychiatria Et Neurologia Japonica, 2011
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Papers by Hitoshi Miyaoka