Papers by Guillermo Belerenian
IntechOpen eBooks, May 6, 2024
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Medical Research Archives
The application of the Alfieri technique in humans is a well-known and pioneering thechnique that... more The application of the Alfieri technique in humans is a well-known and pioneering thechnique that was replaced by modern atrioventricular valve repair strategies.1,2 This technique in canines and also in humans is yet a valid alternative, particullary to canine tricuspid dysplasia.1 The “strategy” consists to transform the “monorificial” dysplastic tricuspid valve insufficiency into a “biorificial” one by means of a suturing at the level of the valve apposition face in the site of greatest regurgitant flow. The surgical field is cleared from blood by means of occlusion of both venae cavae. With this strategy the reduction of the insufficiency jet was achieved in 7 canine carriers of said congenital pathology. The technique demonstrated its anatomical reliability, repeatability, low mortality, and low cost. Of the total number of cases operated on, one patient died the day after surgery, another patient a year later due to non-cardiac causes, and the rest continue under clinical foll...
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Open Veterinary Journal
Background: In human medicine, arrhythmogenic left ventricular cardiomyopathy was described as a ... more Background: In human medicine, arrhythmogenic left ventricular cardiomyopathy was described as a primary disease of the heart characterized by fibroadipose replacement of the myocardium. Case Description: We report the case of a dog, with history of syncope and irregular cardiac rhythm. Electrocardiogram, echocardiography and a 24-hours Holter monitoring showed, respectively, presence of premature ventricular complexes with right bundle branch block morphology, increase of the left ventricle end‐diastolic diameter with preserved fractional shortening and ejection fraction, and a sinus arrhythmia as baseline rhythm with supraventricular tachycardia episodes and ventricular complexes with left bundle branch block morphology. After the death of the canine, postmortem examination showed cardiomegaly. Fibroadipose replacement of the septum and both ventricles, with left ventricle myocardial fibrosis, suggestive of a previous necrosis, was observed. Conclusion: These findings are suggesti...
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Objective: Reporting the use of mechanical ventilation for the treatment of acute respiratory fai... more Objective: Reporting the use of mechanical ventilation for the treatment of acute respiratory failure in a feline patient with acute cardiogenic pulmonary edema. Clinical Case: A 2-year- old castrated female Snowshoe feline suffering from acute dyspnea was referred to the clinic. A 3/6 systolic murmur in the left parasternal region was detected in the physical examination and auscultation also revealed increases in the bronchovesicular sounds. Generalized cardiomegaly and severe increase of lung density in the perihilar region were diagnosed by radiographic evaluation of the chest. The severity of the feline’s respiratory distress, together with the recruitment of accessory muscles and the implied increased risk of respiratory muscle fatigue led us to decide the initiation of mechanical ventilation. Furosemide and topic nitroglycerine were administrated. Twenty four hours after the initiation of mechanical ventilation radiologic examination was repeated and an improvement from the previous study was observed. As a result, weaning the patient from the ventilator was decided. The patient recovered well and 24 hours after being discharged, an echocardiografic evaluation showed concentric left ventricular hypertrophy and a false tendon with insertion from the anterior papillary muscle head to the subaortic endocardium septum across the lumen outflow tract of the left ventricle. Clinical relevance: To the author´s knowledge, it is the first time that the use of mechanical ventilation in feline patients suffering from acute cardiogenic pulmonary edema due to diastolic dysfunction was ever reported.Objetivo: Reportar el empleo de asistencia ventilatoria mecánica para el manejo de la insuficiencia respiratoria aguda en un paciente felino con edema agudo de pulmón de origen cardiogénico Caso Clínico: Un paciente felino de dos años de edad, hembra castrada de raza Snowshoe fue derivado a la clínica por un cuadro de disnea aguda. Al examen físico se detectó un soplo sistólico de intensidad 3/6 a nivel paraesternal izquierdo y se auscultó aumento del murmullo vesicular en ambos campos pulmonares. Se realizó una radiografía de tórax donde se observó cardiomegalia generalizada y aumento severo de la densidad pulmonar a expensas de un patrón alveolar peri-hiliar. Debido al severo cuadro de dificultad respiratoria con reclutamiento de músculos accesorios y al riesgo de fatiga de los músculos respiratorios que esto implica, se decidió iniciar asistencia ventilatoria mecánica (AVM). Se medicó con furosemida y nitroglicerina tópica. A las 24 horas de iniciada la AVM se repitió la radiografía de tórax observándose una mejoría marcada con respecto al estudio anterior por lo que se decidió realizar el destete del ventilador mecánico. El paciente evolucionó favorablemente y a las 24 hs de externado se realizó un ecocardiograma en el cual se observó hipertrofia concéntrica del ventrículo izquierdo y un falso tendón con inserción desde la cabeza del músculo papilar anterior hasta el endocardio del séptum subaórtico cruzando la luz del tracto de salida del ventrículo izquierdo. Relevancia clínica: Al conocimiento de los autores el presente trabajo es el primer reporte del empleo de asistencia ventilatoria mecánica en pacientes felinos con edema agudo de pulmón cardiogénico debido a disfunción diastólica.Fil: Donati, Pablo. UCIcoop; ArgentinaFil: Belerenian, Guillermo. Instituto Pasteur; ArgentinaFil: Mesplet, Maria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; ArgentinaFil: Fernandez, Viviana. UCIcoop; ArgentinaFil: Figuls, Eliana. UCIcoop; ArgentinaFil: Gargiulo, E.. UCIcoop; ArgentinaFil: Guevara, Juan Manuel. UCIcoop; ArgentinaFil: Luztman, Denise. UCIcoop; ArgentinaFil: Moretti, Julieta. UCIcoop; ArgentinaFil: Plataroti, Anabella. UCIcoop; ArgentinaFil: Rodriguez, Sergio. No especifica;Fil: Tunesi, Marcela. UCIcoop; ArgentinaFil: Zayas, Macarena. UCIcoop; ArgentinaFil: Guillemi, Eliana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentin
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Open Veterinary Journal, 2021
Background: Myocardial infarction (MI) is an important cause of death and disability among humans... more Background: Myocardial infarction (MI) is an important cause of death and disability among humans worldwide. Few studies have reported the occurrence of MI in small animals as well. Reports in human medicine indicate that up to 30% of patients with clinical signs compatible with myocardial ischemia suggestive of coronary disease exhibit normal epicardial arteries at angiography. These symptoms have been associated with a syndrome characterized by alterations in cardiac microvasculature, known as coronary microvascular dysfunction (CMD). Aim: This study aimed to describe the necropsy findings and clinical-pathological characterization (when available) of cats with histopathological findings suggesting CMD. Methods: Necropsy records of cats presenting histopathological diagnosis compatible with acute and/or chronic MI, with normal epicardial arteries and microvascular disorders were evaluated. Results: Twenty animals met the inclusion criteria. Eight cats (40%) exhibited findings compatible with mild hypertrophic cardiomyopathy (HCM) without left atrial enlargement, one (5%) presented restrictive cardiomyopathy, and another one (5%) had lesions consistent with histiocytoid cardiomyopathy. The remaining cats (50%) showed alterations compatible with severe HCM with left atrial enlargement. In all cases, epicardial arteries were normal (without obstruction). All the evaluated hearts exhibited myocardial multifocal fibrosis along with replacement of cardiomyocytes by adipose tissue and blood vessels with hyperplasia and hypertrophy of the muscular layer with protrusion of the nuclei of the endothelial cells. Conclusion: These findings suggest the presence of microvascular dysplasia of the coronary arteries. Further studies are necessary to confirm and clinically characterize these results.
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Journal of Veterinary Science, 2019
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Sociedad Latinoamericana de Emergencias y Cuidados Intensivos, May 1, 2015
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Papers by Guillermo Belerenian