Chemical communications (Cambridge, England), Jan 16, 2017
Correction for 'Novel chemical probes for the investigation of nonribosomal peptide assembly&... more Correction for 'Novel chemical probes for the investigation of nonribosomal peptide assembly' by Y. T. Candace Ho et al., Chem. Commun., 2017, 53, 7088-7091.
Chemical communications (Cambridge, England), Jan 27, 2017
Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved... more Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin. Putative intermediate peptide species were isolated and characterised, providing fresh insights into pathway substrate flexibility and paving the way for novel chemoenzymatic approaches towards unnatural peptides.
Feeding of Ralstonia solanacearum with synthetic probes unravels the programming of a partially r... more Feeding of Ralstonia solanacearum with synthetic probes unravels the programming of a partially reducing iterative type I polyketide synthase.
The convenient synthesis of both enantiomers of the piperidine alkaloids such as dumetorine and e... more The convenient synthesis of both enantiomers of the piperidine alkaloids such as dumetorine and epidihydropinidine is described. Pure enantiomers of 2-(2-hydroxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester are used as a common starting material. The ...
Novel, simple, and convenient strategies for diversely functionalized piperidine derivatives have... more Novel, simple, and convenient strategies for diversely functionalized piperidine derivatives have been developed by using different metal catalyzed reactions starting from enantiopure (R)- and (S)-2-piperidylacetaldehyde.
A continuous flow tubing reactor can be used to readily transform methyl or ethyl carboxylic este... more A continuous flow tubing reactor can be used to readily transform methyl or ethyl carboxylic esters into the corresponding hydroxamic acids. Flow rate, reactor volume, and temperature were optimized for the preparation of a small collection of hydroxamic acids. Synthetic advantages were identified as an increased reaction rate and higher product purity. This method was also successfully applied to the multistep preparation of suberoylanilide hydroxamic acid, a potent HDAC inhibitor used in anticancer therapy.
Chemical communications (Cambridge, England), Jan 16, 2017
Correction for 'Novel chemical probes for the investigation of nonribosomal peptide assembly&... more Correction for 'Novel chemical probes for the investigation of nonribosomal peptide assembly' by Y. T. Candace Ho et al., Chem. Commun., 2017, 53, 7088-7091.
Chemical communications (Cambridge, England), Jan 27, 2017
Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved... more Chemical probes were devised and evaluated for the capture of biosynthetic intermediates involved in the bio-assembly of the nonribosomal peptide echinomycin. Putative intermediate peptide species were isolated and characterised, providing fresh insights into pathway substrate flexibility and paving the way for novel chemoenzymatic approaches towards unnatural peptides.
Feeding of Ralstonia solanacearum with synthetic probes unravels the programming of a partially r... more Feeding of Ralstonia solanacearum with synthetic probes unravels the programming of a partially reducing iterative type I polyketide synthase.
The convenient synthesis of both enantiomers of the piperidine alkaloids such as dumetorine and e... more The convenient synthesis of both enantiomers of the piperidine alkaloids such as dumetorine and epidihydropinidine is described. Pure enantiomers of 2-(2-hydroxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester are used as a common starting material. The ...
Novel, simple, and convenient strategies for diversely functionalized piperidine derivatives have... more Novel, simple, and convenient strategies for diversely functionalized piperidine derivatives have been developed by using different metal catalyzed reactions starting from enantiopure (R)- and (S)-2-piperidylacetaldehyde.
A continuous flow tubing reactor can be used to readily transform methyl or ethyl carboxylic este... more A continuous flow tubing reactor can be used to readily transform methyl or ethyl carboxylic esters into the corresponding hydroxamic acids. Flow rate, reactor volume, and temperature were optimized for the preparation of a small collection of hydroxamic acids. Synthetic advantages were identified as an increased reaction rate and higher product purity. This method was also successfully applied to the multistep preparation of suberoylanilide hydroxamic acid, a potent HDAC inhibitor used in anticancer therapy.
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