Journal of emerging technologies and innovative research, 2020
The great biological importance of DHPM nucleus has over the years prompted the development of va... more The great biological importance of DHPM nucleus has over the years prompted the development of various strategies for the synthesis of diversely functionalized dihydropyrimidine derivatives. Making the variations in the original three reacting components can modify the classical Biginelli reaction. The following building blocks have so far been documented as the variations of original Biginelli reaction.
Journal of emerging technologies and innovative research, 2020
Synthetic chalcones having Chloro substituent (3a-3f) along with different functionality on the r... more Synthetic chalcones having Chloro substituent (3a-3f) along with different functionality on the ring. Were examined in-vitro for their antioxidant abilities by DPPH (2,2-diphenyl-1-picryl hydrazine) radical scavenging activity and OH radical scavenging activity. The synthetic chloro-substituted chalcones were found to be reactive towards DPPH radical and also possess good to moderate OH radical scavenging activity. These findings suggest that these chloro-substituted chalcones can be considered as potential antioxidant agents which might be further explored for the design of lead antioxidant drug candidates. Keywordss Chloro-chalcones, antioxidant, radical scavenging activity.
New chalcones (3a-g) were synthesized from 5-chloro-2-methoxybenzaldehyde (2) and halohydroxysubs... more New chalcones (3a-g) were synthesized from 5-chloro-2-methoxybenzaldehyde (2) and halohydroxysubstitued acetophenones (1a-g) via Claisen-Schmidt condensation. Further new flavones (4a-g) were synthesized by oxidative cyclisation of chalcones (3a-g).The structure of synthetic compounds were confirmed by IR, 1H NMR and elemental analysis. These compounds were screened for their antibacterial activity and studied the effect on seed germination of wheat (Triticum aestivum).
This article describes simple and efficient method for the iodination of different aromatic amine... more This article describes simple and efficient method for the iodination of different aromatic amines, hydroxy aromatic aldehydes, hydroxy acetophenones and phenols using iodine and iodic acid in ethanol as a solvent. Notable advantages include mild reaction condition, no ...
ABSTRACT 6,8-dichloro-3-amino-2-methylquinazolin-4 (3H)-one have been prepared from anthranilic a... more ABSTRACT 6,8-dichloro-3-amino-2-methylquinazolin-4 (3H)-one have been prepared from anthranilic acid by chlorination using molecular chlorine. This quinazolin-4 (3H)-one, on condensing with substituted haloaldehydes in presence of traces of acetic acid yielded schiff bases, which on reacting with chloroacetylchloride yielded 2-azetidinones and with thioglycolic and gave 4-thiazolidinones in good yield. All the synthesised schiff bases, 2-azetidinones and 4-thiazolidinones were screened for their antibacterial activity against E. coli, S. aureus, X. citri and E. carotovora. Some of the compounds show better activity than standard antibiotic Tetracycline.
Journal of emerging technologies and innovative research, 2020
The great biological importance of DHPM nucleus has over the years prompted the development of va... more The great biological importance of DHPM nucleus has over the years prompted the development of various strategies for the synthesis of diversely functionalized dihydropyrimidine derivatives. Making the variations in the original three reacting components can modify the classical Biginelli reaction. The following building blocks have so far been documented as the variations of original Biginelli reaction.
Journal of emerging technologies and innovative research, 2020
Synthetic chalcones having Chloro substituent (3a-3f) along with different functionality on the r... more Synthetic chalcones having Chloro substituent (3a-3f) along with different functionality on the ring. Were examined in-vitro for their antioxidant abilities by DPPH (2,2-diphenyl-1-picryl hydrazine) radical scavenging activity and OH radical scavenging activity. The synthetic chloro-substituted chalcones were found to be reactive towards DPPH radical and also possess good to moderate OH radical scavenging activity. These findings suggest that these chloro-substituted chalcones can be considered as potential antioxidant agents which might be further explored for the design of lead antioxidant drug candidates. Keywordss Chloro-chalcones, antioxidant, radical scavenging activity.
New chalcones (3a-g) were synthesized from 5-chloro-2-methoxybenzaldehyde (2) and halohydroxysubs... more New chalcones (3a-g) were synthesized from 5-chloro-2-methoxybenzaldehyde (2) and halohydroxysubstitued acetophenones (1a-g) via Claisen-Schmidt condensation. Further new flavones (4a-g) were synthesized by oxidative cyclisation of chalcones (3a-g).The structure of synthetic compounds were confirmed by IR, 1H NMR and elemental analysis. These compounds were screened for their antibacterial activity and studied the effect on seed germination of wheat (Triticum aestivum).
This article describes simple and efficient method for the iodination of different aromatic amine... more This article describes simple and efficient method for the iodination of different aromatic amines, hydroxy aromatic aldehydes, hydroxy acetophenones and phenols using iodine and iodic acid in ethanol as a solvent. Notable advantages include mild reaction condition, no ...
ABSTRACT 6,8-dichloro-3-amino-2-methylquinazolin-4 (3H)-one have been prepared from anthranilic a... more ABSTRACT 6,8-dichloro-3-amino-2-methylquinazolin-4 (3H)-one have been prepared from anthranilic acid by chlorination using molecular chlorine. This quinazolin-4 (3H)-one, on condensing with substituted haloaldehydes in presence of traces of acetic acid yielded schiff bases, which on reacting with chloroacetylchloride yielded 2-azetidinones and with thioglycolic and gave 4-thiazolidinones in good yield. All the synthesised schiff bases, 2-azetidinones and 4-thiazolidinones were screened for their antibacterial activity against E. coli, S. aureus, X. citri and E. carotovora. Some of the compounds show better activity than standard antibiotic Tetracycline.
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