Papers by Cristian Fajardo
European journal of clinical pharmacology, Jan 30, 2018
To develop a population pharmacokinetic (PK) model for vancomycin in Chinese neonates and infants... more To develop a population pharmacokinetic (PK) model for vancomycin in Chinese neonates and infants less than 2 months of age (young infants) with a wide gestational age range, in order to determine the appropriate dosing regimen for this population. We performed a retrospective chart review of patients from the neonatal intensive care unit (NICU) at Children's Hospital of Fudan University to identify neonates and young infants treated with vancomycin from May 2014 to May 2017. Vancomycin concentrations and covariates were utilized to develop a one-compartment model with first-order elimination. The predictive performance of the final model was assessed by both internal and external evaluation, and the relationship between trough concentration and AUC was investigated. Monte Carlo simulations were performed to design an initial dosing schedule targeting an AUC ≥ 400. The analysis included a total of 330 concentration-time data points from 213 neonates and young infants with gestat...
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Papers by Cristian Fajardo