Papers by Citlaltepetl Salinas
Journal of Neurology and Neuroscience, 2021
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Clinical Neurology and Neurosurgery, Sep 1, 2020
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Journal of Neuro-oncology, Apr 4, 2007
Mucus-secreting adenomas or acinar adenoma of the choroid plexus are very rare. We report the cas... more Mucus-secreting adenomas or acinar adenoma of the choroid plexus are very rare. We report the case of a 79-year-old male with a 3-year history of occipital headaches with vomiting, ataxia and cerebellar signs. He was first seen due to difficulty while walking. He was admitted to the hospital with significant tumor expansion and clinical deterioration. CT and MRI revealed obstructive hydrocephalus secondary to a large fourth ventricular cyst mass, which enhanced markedly on contrast administration. Pathological findings were consistent with an acinar choroid plexus adenoma. The tumor was attached to the ependymal lining and was strongly adhered to the walls and floor of the IV ventricle. Post-operative bleeding complicated partial removal of this tumor. The patient died 6 h after surgery.
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RESUMEN El amiloide es un material fibrillar que se deposita en forma extracelular en diferentes ... more RESUMEN El amiloide es un material fibrillar que se deposita en forma extracelular en diferentes órganos y en diferen-tes circunstancias. Se clasifica según sus componentes bioquímicos y sus precursores. Diseño del estudio: se realizó un estudio descriptivo, retrospectivo, histopato-lógico con el propósito de identificar el depósito de amiloide en los tumores de plexos coroides. Resultados: estudiamos 37 casos de tumores de plexos coroides, 27 fueron papilomas y 10 carcinomas, 26 fueron mujeres y 11 hombres. El amiloide se presentó en el 40.5, 27% en papilomas y 13.5% en carcinomas (p.483), de los cuales 12 casos (32.4%) fueron mujeres y 3(8.1%) fueron hombres (p.342), dos de los carcinomas presentaban abundante amiloide, uno de ellos además presentaba metaplasia ósea. Otros hallazgos fueron: fibrosis en el 70.3%, vasos gruesos en el 24.3%, infiltrado inflamatorio en el 54.1% (p.066). El seguimiento clínico posqui-rúrgico fue hasta 120 meses; sin embargo, en los casos que presentaro...
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Clinical Neurology and Neurosurgery, 2020
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Ifosfamide blood concentrations are necessary to monitor its therapeutic response, avoiding any a... more Ifosfamide blood concentrations are necessary to monitor its therapeutic response, avoiding any adverse effect. We developed and validated an analytical method by UPLC-MS/MS to quantify ifosfamide in dried blood spots (DBS). Blood samples were collected onWhatman 9031 filter paper cards. Five 3 mm disks were punched out from each dried blood spot. Aceto-nitrile and ethyl acetate were used for drug extraction. Chromatographic separation was carried out in an Acquity UPLC equipment with a BEH-C18 column, 2.1 x 100mm, 1.7 μm (Waters1). The mobile phase consisted in 5 mMammonium formate and methanol:acetonitrile (40:48:12 v/v/v) at 0.2 mL/min. LC-MS/MS detection was done by ESI+ andmultiple reaction modemoni-toring, ionic transitions were m/z1+ 260.99> 91.63 for ifosfamide and 261.00> 139.90 for cyclo-phosphamide (internal standard). This method was linear within a 100–10000 ng/mL range
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Attribution License, which permits unrestricted use, distribution, and reproduction in any medium... more Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Major depressive disorder patients present chronic stress and decreased immunity.TheWistar-Kyoto rat (WKY) is a strain in which the hypothalamic-pituitary-adrenal axis is overactivated. To determine whether chronic stress induces changes in corticosterone levels and splenic lymphoid tissue, 9-week-old male rats were subject to restraint stress (3 h daily), chemical stress (hydrocortisone
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We report a female 40 years-old with familiar history; father death with cerebral hemorrhage at 4... more We report a female 40 years-old with familiar history; father death with cerebral hemorrhage at 42 year-old. Seven brother with blood hypertension, one sister with renal transplantation. She presented preeclampsia in last pregnant. 13 year before she was been treated of blood hypertensions. She presented nauseas, vomiting and intense cephalea and loss of alerting state until coma and died. Clip of the aneurysm was performed. The CT-scan showed subdural hemorrhage and multiple aneurysm. Abdominal CT-scan showed multiple renal cyst, renal calculi and hepatic cyst. We considerate the blood hypertension was the cause of the aneurysm rupture. The association of polycystic kidney disease and cerebral aneurysms is rare, the subdural hemorrhage is cause of death in the majors of the cases. We report a rare case with these rare association. Key word: polycystic kidney disease, cerebral aneurysms; subdural hemorrhage. Arch Neurocien (Mex) Vol. 15, No. 1: 56-60; 2010
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PLOS ONE, 2015
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BioMed Research International, 2013
Major depressive disorder patients present chronic stress and decreased immunity. The Wistar-Kyot... more Major depressive disorder patients present chronic stress and decreased immunity. The Wistar-Kyoto rat (WKY) is a strain in which the hypothalamic-pituitary-adrenal axis is overactivated. To determine whether chronic stress induces changes in corticosterone levels and splenic lymphoid tissue, 9-week-old male rats were subject to restraint stress (3 h daily), chemical stress (hydrocortisone treatment, 50 mg/Kg weight), mixed stress (restraint plus hydrocortisone), or control treatment (without stress) for 1, 4, and 7 weeks. The serum corticosterone levels by RIA and spleens morphology were analyzed. Corticosterone levels as did the structure, size of the follicles and morphology of the parenchyma (increase in red pulp) in the spleen, varied depending on time and type of stressor. These changes indicate that chronic stress alters the immune response in the spleen in WKY rats by inducing morphological changes, explaining in part the impaired immunity that develops in organisms that are...
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PM&R, 2014
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Tuberculosis, 2010
Meningeal tuberculosis is a severe type of extrapulmonary disease, which is thought to begin with... more Meningeal tuberculosis is a severe type of extrapulmonary disease, which is thought to begin with respiratory infection, followed by hematogenous dissemination and brain infection. Host genetic susceptibility factors and specific mycobacterial substrains could be involved in its development. From an epidemiological study in Colombia, we selected three Mycobacterium tuberculosis clinical strains isolated from the cerebrospinal fluid (CSF) of patients with meningeal tuberculosis, and used them to infect BALB/c mice through the intratracheal route. These strains showed a distinctive spoligotype pattern. The course of infection in terms of strain virulence (mice survival, bacillary loads in lungs), bacilli dissemination and extrapulmonary infection (bacilli loads in blood, brain, liver, kidney and spleen), and immune responses (cytokine expression determined by real time PCR in brain and lung) was studied and compared with that induced by the laboratory strain H37Rv and other five clinical strains isolated from patients with pulmonary TB. All the clinical isolates from meningeal TB patients disseminated extensively through the hematogenous route infecting the brain, producing inflammation in the cerebral parenchyma and meninges, whereas H37Rv and clinical isolates from pulmonary TB patients showed very limited efficiency to infect the brain. Thus, it seems that mycobacterial strains with a distinctive genotype are able to disseminate extensively after the respiratory infection and infect the brain.
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Journal of Neuro-Oncology, 2007
Mucus-secreting adenomas or acinar adenoma of the choroid plexus are very rare. We report the cas... more Mucus-secreting adenomas or acinar adenoma of the choroid plexus are very rare. We report the case of a 79-year-old male with a 3-year history of occipital headaches with vomiting, ataxia and cerebellar signs. He was first seen due to difficulty while walking. He was admitted to the hospital with significant tumor expansion and clinical deterioration. CT and MRI revealed obstructive hydrocephalus secondary to a large fourth ventricular cyst mass, which enhanced markedly on contrast administration. Pathological findings were consistent with an acinar choroid plexus adenoma. The tumor was attached to the ependymal lining and was strongly adhered to the walls and floor of the IV ventricle. Post-operative bleeding complicated partial removal of this tumor. The patient died 6 h after surgery.
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Arquivos de Neuro-Psiquiatria, 2009
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…, 2010
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Cancers, Jan 19, 2018
Signal transducer and activator of transcription 1 (STAT1) is part of the Janus kinase (JAK/STAT)... more Signal transducer and activator of transcription 1 (STAT1) is part of the Janus kinase (JAK/STAT) signaling pathway that controls critical events in intestinal immune function related to innate and adaptive immunity. Recent studies have implicated STAT1 in tumor⁻stroma interactions, and its expression and activity are perturbed during colon cancer. However, the role of STAT1 during the initiation of inflammation-associated cancer is not clearly understood. To determine the role of STAT1 in colitis-associated colorectal cancer (CAC), we analyzed the tumor development and kinetics of cell recruitment in wild-type WT or STAT1 mice treated with azoxymethane (AOM) and dextran sodium sulfate (DSS). Following CAC induction, STAT1 mice displayed an accelerated appearance of inflammation and tumor formation, and increased damage and scores on the disease activity index (DAI) as early as 20 days after AOM-DSS exposure compared to their WT counterparts. STAT1 mice showed elevated colonic epith...
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Papers by Citlaltepetl Salinas