Papers by Carolina Poncini
Frontiers in Cellular and Infection Microbiology, Jul 6, 2021
Bookmarks Related papers MentionsView impact
Early interactions between natural killer (NK) and dendritic cells (DC) shape the immune response... more Early interactions between natural killer (NK) and dendritic cells (DC) shape the immune response at the frontier of innate and adaptive immunity. Activated NK cells participate in maturation or deletion of DCs that remain immature. We previously demonstrated that infection with a high virulence (HV) population of the protozoan parasite <i>Trypanosoma cruzi</i> downmodulates DC maturation and T-cell activation capacity. Here, we evaluated the role of NK cells in regulating the maturation level of DCs. Shortly after infection with HV <i>T. cruzi</i>, DCs in poor maturation status begin to accumulate in mouse spleen. Although infection induces NK cell cytotoxicity and cytokine production, NK cells from mice infected with HV <i>T. cruzi</i> exhibit reduced ability to lyse and fail to induce maturation of bone marrow-derived immature DCs (iDCs). NK-mediated lysis of iDCs is restored by in vitro blockade of the IL-10 receptor during NK-DC interaction o...
Bookmarks Related papers MentionsView impact
Frontiers in Immunology, 2018
Bookmarks Related papers MentionsView impact
ACS infectious diseases, Apr 22, 2024
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Infection and Immunity, Jun 1, 2008
Bookmarks Related papers MentionsView impact
Frontiers in Cellular and Infection Microbiology, Aug 3, 2018
Bookmarks Related papers MentionsView impact
Frontiers in Cellular and Infection Microbiology, 2018
Bookmarks Related papers MentionsView impact
Http Digital Bl Fcen Uba Ar, 2010
Bookmarks Related papers MentionsView impact
Frontiers in Cellular and Infection Microbiology
Extracellular vesicles (EVs) include a heterogeneous group of particles. Microvesicles, apoptotic... more Extracellular vesicles (EVs) include a heterogeneous group of particles. Microvesicles, apoptotic bodies and exosomes are the most characterized vesicles. They can be distinguished by their size, morphology, origin and molecular composition. To date, increasing studies demonstrate that EVs mediate intercellular communication. EVs reach considerable interest in the scientific community due to their role in diverse processes including antigen-presentation, stimulation of anti-tumoral immune responses, tolerogenic or inflammatory effects. In pathogens, EV shedding is well described in fungi, bacteria, protozoan and helminths parasites. For Trypanosoma cruzi EV liberation and protein composition was previously described. Dendritic cells (DCs), among other cells, are key players promoting the immune response against pathogens and also maintaining self-tolerance. In previous reports we have demonstrate that T. cruzi downregulates DCs immunogenicity in vitro and in vivo. Here we analyze EV...
Bookmarks Related papers MentionsView impact
Frontiers in Microbiology
Trypanosoma cruzi, the protozoan parasite causative agent of Chagas disease, affects about seven ... more Trypanosoma cruzi, the protozoan parasite causative agent of Chagas disease, affects about seven million people worldwide, representing a major global public health concern with relevant socioeconomic consequences, particularly in developing countries. In this review, we discuss the multiple roles of galectins, a family of β-galactoside-binding proteins, in modulating both T. cruzi infection and immunoregulation. Specifically, we focus on galectin-driven circuits that link parasite invasion and inflammation and reprogram innate and adaptive immune responses. Understanding the dynamics of galectins and their β-galactoside-specific ligands during the pathogenesis of T. cruzi infection and elucidating their roles in immunoregulation, inflammation, and tissue damage offer new rational opportunities for treating this devastating neglected disease.
Bookmarks Related papers MentionsView impact
Bookmarks Related papers MentionsView impact
Frontiers in Cellular and Infection Microbiology, 2020
Bookmarks Related papers MentionsView impact
European Journal of Immunology, 2017
Bookmarks Related papers MentionsView impact
International Journal for Parasitology, 2017
Bookmarks Related papers MentionsView impact
Veterinary Parasitology, 2016
Bookmarks Related papers MentionsView impact
The Journal of Immunology, 2015
Galectin-1 (Gal-1), an endogenous glycan-binding protein, is widely distributed at sites of infla... more Galectin-1 (Gal-1), an endogenous glycan-binding protein, is widely distributed at sites of inflammation and microbial invasion. Despite considerable progress regarding the immunoregulatory activity of this lectin, the role of endogenous Gal-1 during acute parasite infections is uncertain. In this study, we show that Gal-1 functions as a negative regulator to limit host-protective immunity following intradermal infection with Trypanosoma cruzi. Concomitant with the upregulation of immune inhibitory mediators, including IL-10, TGF-β1, IDO, and programmed death ligand 2, T. cruzi infection induced an early increase of Gal-1 expression in vivo. Compared to their wild-type (WT) counterpart, Gal-1–deficient (Lgals1−/−) mice exhibited reduced mortality and lower parasite load in muscle tissue. Resistance of Lgals1−/− mice to T. cruzi infection was associated with a failure in the activation of Gal-1–driven tolerogenic circuits, otherwise orchestrated by WT dendritic cells, leading to seco...
Bookmarks Related papers MentionsView impact
Veterinary Parasitology, 2013
Bookmarks Related papers MentionsView impact
Vaccine, 2010
Bookmarks Related papers MentionsView impact
Parasitology, 2009
SUMMARYInfection with a myotropicTrypanosoma cruziclone induces maternal fertility failure. In th... more SUMMARYInfection with a myotropicTrypanosoma cruziclone induces maternal fertility failure. In the current work, we evaluated whether reduction of maternal parasitaemia before mating has beneficial effects on pregnancy outcome. Female mice were subjected to benznidazole (Bz) treatment after infection. On day 30 of therapy, mating was assessed and pregnancy outcome was determined on day 14 of gestation. Fetal resorptions diminished inT. cruzi-infected Bz-treated mice compared withT. cruzi-infected untreated mice. This was in agreement with the reduction in the blood/solid tissue parasite load and with the percentage of necrotic foci in placental samples fromT. cruzi-infected Bz-treated females. To study eventual changes in the immune homeostasis ofT. cruzi-infected Bz-treated mice, activation of the immune system was evaluated at the end of Bz therapy and before mating. We found specific IgG1reduction resulting in a predominance of specific IgG2a, reduced numbers of CD69+CD4+cells an...
Bookmarks Related papers MentionsView impact
Uploads
Papers by Carolina Poncini