The effects of clonidine, naloxone, and their combination on arterial blood pressure (BP), heart ... more The effects of clonidine, naloxone, and their combination on arterial blood pressure (BP), heart rate (HR), and hemodynamic and biochemical parameters were examined in 29 patients with essential hypertension. Treatment for 3 days with 0.3 mg/day clonidine reduced BP and HR, and these effects were quickly reversed by a single injection of 0.4 mg iv naloxone in 17 of the patients (responders), but not in the remaining 12 (nonresponders). Responders had higher control values for cardiac output, stroke index, plasma renin activity (PRA), and plasma epinephrine levels than did nonresponders. Basal BP was similar in the two groups, but clonidine decreased BP, PRA, and plasma epinephrine more in responders than in nonresponders. Naloxone given during placebo treatment had no significant effects. During clonidine treatment naloxone increased BP, HR, total peripheral resistance, PRA, and plasma epinephrine and norepinephrine, and decreased stroke volume in responders, whereas in nonresponder...
Maternal age at childbirth is associated with changes in smoking status between late adolescence ... more Maternal age at childbirth is associated with changes in smoking status between late adolescence and early middle age : results from 22 years of follow-up
Plasma levels of soluble intercellular adhesion molecule 1 (sICAM-1) and monocyte chemoattractant... more Plasma levels of soluble intercellular adhesion molecule 1 (sICAM-1) and monocyte chemoattractant protein 1 (sMCP-1) are associated with increased risk for future coronary events. However, the effect of statins on these inflammatory markers has hardly been studied. We analyzed whether treatment with the different doses of atorvastatin affects sICAM-1 and sMCP-1 plasma levels in subjects at high cardiovascular risk. Achieve Cholesterol Targets Fast with Atorvastatin Stratified Titration was a 12-week, prospective, multicenter, open-label trial that enrolled a total of 2117 subjects with coronary heart disease (CHD), CHD equivalent (defined as diabetes, peripheral vascular disease, or cerebrovascular disease), or a 10-year CHD risk >20%. Subjects with low-density-lipoprotein cholesterol between 100 and 220 mg/dL (2.6-5.7 mmol/L) and triglycerides <600 mg/dL (6.8 mmol/L) were assigned to atorvastatin (10-80 mg/d) based on low-density-lipoprotein cholesterol at screening. The Atorvastatin on Inflammatory Markers study included statin-free patients (N = 1078). At baseline, 52%, 14%, 12%, and 22% of subjects were assigned to doses of 10, 20, 40, and 80 mg, respectively. Levels of sICAM-1 [geometric mean (95% confidence interval); 283.8 (278.1-289.6) vs 131.9 (127.2-136.6) ng/mL, P < .0001] and sMCP-1 [164.1 (159.9-168.2) vs 131.1 (123.1-139.6 pg/mL, P < .0001] were increased in subjects at high cardiovascular risk compared to healthy subjects (n = 130). In the whole population, sICAM-1 and sMCP-1 levels were reduced by atorvastatin [% change (95% confidence interval); -2.2 (-3.8 to -0.6); -4.1 (-6.1 to -2); P = .006 and P = .0002, respectively]. All doses of atorvastatin diminished sICAM-1 and sMCP-1 levels in the highest quartile. Short treatment with atorvastatin reduced sICAM-1 and sMCP-1 plasma levels showing anti-inflammatory effects in subjects at high cardiovascular risk.
Acta medica Academiae Scientiarum Hungaricae, 1977
The effect of 0.15 IU/min vasopressin (VA) administered intracoronarily on postocclusion reaction... more The effect of 0.15 IU/min vasopressin (VA) administered intracoronarily on postocclusion reactions following 15 sec, 30 sec, 60 sec, and 120 sec occlusions of the left coronaries of the isolated fibrillating dog heart were studied at constant pressure or constant volume perfusion with arterial blood of another dog. Basal perfusion pressure was kept at the level of 150 mmHg. Preocclusion state and postocclusion reactions were characterized by changes in coronary conductance. Peak conductance, maximum conductance, reactivity, time to peak conductance, mean transit time and repayment were computed for characterizing reactive hyperaemia. In the control state the post-occlusive conductance--time curve was higher, but shorter in duration with constant pressure perfusion than with constant volume perfusion. Upon the administration of VA, basal conductance decreased considerably while with constant pressure perfusion the hyperaemic reactions underwent hardly any change. In contrast, using c...
Acta physiologica Academiae Scientiarum Hungaricae, 1980
Cardiac output (CO), blood pressure (BP) and heart rate (HR) were estimated in 13 non-athletes, i... more Cardiac output (CO), blood pressure (BP) and heart rate (HR) were estimated in 13 non-athletes, in 10 highly trained athletes and in 8 lower-class athletes at rest. HR and BP were found to be lower in both trained groups than in the controls. CO was lower in the top athletes, while it proved to be higher in the lower-class athletes. Total peripheral resistance (TPR) was higher in the top athletes while it was found to be reduced in the lower-class athletes than in the controls. These results indicate that in the maintanance of resting blood pressure level in the physically trained subjects alpha adrenergic mechanisms predominate whereas the share of beta influences is lower, however, this shift is observed only in the highly trained, top-rank endurance athletes.
Renovascular disorders are rather rare in children and adolescents but have severe consequences d... more Renovascular disorders are rather rare in children and adolescents but have severe consequences due to complicating hypertension. Six cases successfully treated by surgery are described. The importance of early diagnosis and vascular correction is stressed; normalization of blood pressure has been achieved in every case.
The effects of clonidine, naloxone, and their combination on arterial blood pressure (BP), heart ... more The effects of clonidine, naloxone, and their combination on arterial blood pressure (BP), heart rate (HR), and hemodynamic and biochemical parameters were examined in 29 patients with essential hypertension. Treatment for 3 days with 0.3 mg/day clonidine reduced BP and HR, and these effects were quickly reversed by a single injection of 0.4 mg iv naloxone in 17 of the patients (responders), but not in the remaining 12 (nonresponders). Responders had higher control values for cardiac output, stroke index, plasma renin activity (PRA), and plasma epinephrine levels than did nonresponders. Basal BP was similar in the two groups, but clonidine decreased BP, PRA, and plasma epinephrine more in responders than in nonresponders. Naloxone given during placebo treatment had no significant effects. During clonidine treatment naloxone increased BP, HR, total peripheral resistance, PRA, and plasma epinephrine and norepinephrine, and decreased stroke volume in responders, whereas in nonresponder...
Maternal age at childbirth is associated with changes in smoking status between late adolescence ... more Maternal age at childbirth is associated with changes in smoking status between late adolescence and early middle age : results from 22 years of follow-up
Plasma levels of soluble intercellular adhesion molecule 1 (sICAM-1) and monocyte chemoattractant... more Plasma levels of soluble intercellular adhesion molecule 1 (sICAM-1) and monocyte chemoattractant protein 1 (sMCP-1) are associated with increased risk for future coronary events. However, the effect of statins on these inflammatory markers has hardly been studied. We analyzed whether treatment with the different doses of atorvastatin affects sICAM-1 and sMCP-1 plasma levels in subjects at high cardiovascular risk. Achieve Cholesterol Targets Fast with Atorvastatin Stratified Titration was a 12-week, prospective, multicenter, open-label trial that enrolled a total of 2117 subjects with coronary heart disease (CHD), CHD equivalent (defined as diabetes, peripheral vascular disease, or cerebrovascular disease), or a 10-year CHD risk >20%. Subjects with low-density-lipoprotein cholesterol between 100 and 220 mg/dL (2.6-5.7 mmol/L) and triglycerides <600 mg/dL (6.8 mmol/L) were assigned to atorvastatin (10-80 mg/d) based on low-density-lipoprotein cholesterol at screening. The Atorvastatin on Inflammatory Markers study included statin-free patients (N = 1078). At baseline, 52%, 14%, 12%, and 22% of subjects were assigned to doses of 10, 20, 40, and 80 mg, respectively. Levels of sICAM-1 [geometric mean (95% confidence interval); 283.8 (278.1-289.6) vs 131.9 (127.2-136.6) ng/mL, P < .0001] and sMCP-1 [164.1 (159.9-168.2) vs 131.1 (123.1-139.6 pg/mL, P < .0001] were increased in subjects at high cardiovascular risk compared to healthy subjects (n = 130). In the whole population, sICAM-1 and sMCP-1 levels were reduced by atorvastatin [% change (95% confidence interval); -2.2 (-3.8 to -0.6); -4.1 (-6.1 to -2); P = .006 and P = .0002, respectively]. All doses of atorvastatin diminished sICAM-1 and sMCP-1 levels in the highest quartile. Short treatment with atorvastatin reduced sICAM-1 and sMCP-1 plasma levels showing anti-inflammatory effects in subjects at high cardiovascular risk.
Acta medica Academiae Scientiarum Hungaricae, 1977
The effect of 0.15 IU/min vasopressin (VA) administered intracoronarily on postocclusion reaction... more The effect of 0.15 IU/min vasopressin (VA) administered intracoronarily on postocclusion reactions following 15 sec, 30 sec, 60 sec, and 120 sec occlusions of the left coronaries of the isolated fibrillating dog heart were studied at constant pressure or constant volume perfusion with arterial blood of another dog. Basal perfusion pressure was kept at the level of 150 mmHg. Preocclusion state and postocclusion reactions were characterized by changes in coronary conductance. Peak conductance, maximum conductance, reactivity, time to peak conductance, mean transit time and repayment were computed for characterizing reactive hyperaemia. In the control state the post-occlusive conductance--time curve was higher, but shorter in duration with constant pressure perfusion than with constant volume perfusion. Upon the administration of VA, basal conductance decreased considerably while with constant pressure perfusion the hyperaemic reactions underwent hardly any change. In contrast, using c...
Acta physiologica Academiae Scientiarum Hungaricae, 1980
Cardiac output (CO), blood pressure (BP) and heart rate (HR) were estimated in 13 non-athletes, i... more Cardiac output (CO), blood pressure (BP) and heart rate (HR) were estimated in 13 non-athletes, in 10 highly trained athletes and in 8 lower-class athletes at rest. HR and BP were found to be lower in both trained groups than in the controls. CO was lower in the top athletes, while it proved to be higher in the lower-class athletes. Total peripheral resistance (TPR) was higher in the top athletes while it was found to be reduced in the lower-class athletes than in the controls. These results indicate that in the maintanance of resting blood pressure level in the physically trained subjects alpha adrenergic mechanisms predominate whereas the share of beta influences is lower, however, this shift is observed only in the highly trained, top-rank endurance athletes.
Renovascular disorders are rather rare in children and adolescents but have severe consequences d... more Renovascular disorders are rather rare in children and adolescents but have severe consequences due to complicating hypertension. Six cases successfully treated by surgery are described. The importance of early diagnosis and vascular correction is stressed; normalization of blood pressure has been achieved in every case.
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