Papers by Yehezkel Ben-Ari
Although several investigations have shown that the local GABAergic circuit in the rat hippocampu... more Although several investigations have shown that the local GABAergic circuit in the rat hippocampus is functional very early in development, this result has not been yet completed by the investigation of the full dendritic and axonal arborization of the neonatal interneurones. In the present study, intracellular injection of biocytin was used to assess the branching pattern of interneurones in the hippocampal CA3 region of rat between 2 and 6 days of age. Based on their dendritic morphology, the biocytin-filled interneurones were divided into four classes: bipolar, stellate, pyramidal-like and fusiform interneurones. About half of the biocytin-filled neonatal interneurones exhibited dendritic or somatic filopodial processes. The axonal arbors of the filled-interneurones were widely spread into the CA3 region, and in four out of nine cases extended beyond the CA3 region to branch into the CA1 region. These results show that, despite immature features, the filopodial processes, the hippocampal interneurones are well developed early in development at a time when their target cells, the pyramidal neurones, are still developing. These observations are consistent with a trophic role that GABA may play early in development.
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During development, when synapses start to be established, a primitive form of
network-driven act... more During development, when synapses start to be established, a primitive form of
network-driven activity provides most of the synaptic activity. This pattern
enables a high degree of synchrony in immature neurons in spite of the small
number of functional synapses and could participate in activity-dependent
growth and synapse formation. Relying on the giant depolarizing potentials
that provide most of the synaptic activity in the developing hippocampus, this
article reviews the common properties and generating mechanisms of these
patterns, and particularly the role of the early depolarizing action of GABAA and
glycine receptors and the sequential expression of GABA and glutamate
synapses. Patterns similar to giant depolarizing potentials have been observed
in a wide range of structures and species suggesting that there is a temporal
template throughout evolution that constitutes an essential step in the
formation of functional networks
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Papers by Yehezkel Ben-Ari
network-driven activity provides most of the synaptic activity. This pattern
enables a high degree of synchrony in immature neurons in spite of the small
number of functional synapses and could participate in activity-dependent
growth and synapse formation. Relying on the giant depolarizing potentials
that provide most of the synaptic activity in the developing hippocampus, this
article reviews the common properties and generating mechanisms of these
patterns, and particularly the role of the early depolarizing action of GABAA and
glycine receptors and the sequential expression of GABA and glutamate
synapses. Patterns similar to giant depolarizing potentials have been observed
in a wide range of structures and species suggesting that there is a temporal
template throughout evolution that constitutes an essential step in the
formation of functional networks
network-driven activity provides most of the synaptic activity. This pattern
enables a high degree of synchrony in immature neurons in spite of the small
number of functional synapses and could participate in activity-dependent
growth and synapse formation. Relying on the giant depolarizing potentials
that provide most of the synaptic activity in the developing hippocampus, this
article reviews the common properties and generating mechanisms of these
patterns, and particularly the role of the early depolarizing action of GABAA and
glycine receptors and the sequential expression of GABA and glutamate
synapses. Patterns similar to giant depolarizing potentials have been observed
in a wide range of structures and species suggesting that there is a temporal
template throughout evolution that constitutes an essential step in the
formation of functional networks