Papers by Androniki Kozana
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Neuroblastic tumours constitute a heterogenous group of tumours with diverse presentation, variab... more Neuroblastic tumours constitute a heterogenous group of tumours with diverse presentation, variable malignant behaviour and prognosis. Image Defined Risk Factors (IDRFs) have been described in the International Neuroblastoma Risk Group Staging System (INRGSS). IDRFs refer to compartmental involvement, the effect of masses to vital organs or anatomic structures and their relation to neurovascular bundles and airway. CT has been traditionally recommended for imaging children with neuroblastoma. MRI is increasingly being utilised for the diagnosis, staging and follow-up of children with neuroblastic tumours and is considered an acceptable modality for clinical trials. Appropriate structured reporting is crucial for communication with surgeons. This pictorial essay focuses on the MRI appearances of neuroblastic tumours, aims to familiarise radiologists with relevant terminology and the routine use of IDRFs when reporting MR imaging studies preoperatively; it provides a concise checklist...
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Gadolinium based contrast agents (GBCAs) have been widely used intravenously in MRI examinations ... more Gadolinium based contrast agents (GBCAs) have been widely used intravenously in MRI examinations and are considered relatively safe in patients with intact renal function. However, since 2014, repeated administrations of GBCAs have been associated to high MRI signal intensity in deep brain nuclei, on unenhanced T1-weighted images, a finding that has been attributed to gadolinium (Gd) parenchymal deposition. Deep brain nuclei Gd deposition is variable among different agents available for clinical practice and is considered greater with linear GBCAs compared to macrocyclic agents. The clinical significance of Gd brain retention has not been extensively studied and remains, to a great extent, undetermined. In this review article, the biochemical structure of GBCAs, the clinical and pathologic studies investigating morphological and histological changes after multiple intravenous Gd administration, the suggested pathogenetic mechanisms and the recent recommendations towards safe use of ...
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To cite: Hatzidakis A, Kozana A, Petrakis I, et al. BMJ Case Rep Published online: [please includ... more To cite: Hatzidakis A, Kozana A, Petrakis I, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/ bcr-2014-206962 SUMMARY We describe a case of a 28-year-old man who presented with symptomatic, right-sided, large adrenal cyst recurrence 9 months after laparoscopic decortication. Final treatment was achieved by means of percutaneous aspiration and ethanol ablation. On 6-month follow-up the patient was asymptomatic and the cyst remained minimised. In our opinion, percutaneous treatment with alcohol ablation of primary benign symptomatic or recurrent uncomplicated adrenal cysts should be considered as an effective alternative method when patients are frail or surgery fails to resolve the problem.
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The Pan African Medical Journal, 2020
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Physica Medica, 2018
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Physica Medica, 2018
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EJVES Short Reports, 2019
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Physica Medica, 2018
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BMJ case reports, Jan 22, 2014
We describe a case of a 28-year-old man who presented with symptomatic, right-sided, large adrena... more We describe a case of a 28-year-old man who presented with symptomatic, right-sided, large adrenal cyst recurrence 9 months after laparoscopic decortication. Final treatment was achieved by means of percutaneous aspiration and ethanol ablation. On 6-month follow-up the patient was asymptomatic and the cyst remained minimised. In our opinion, percutaneous treatment with alcohol ablation of primary benign symptomatic or recurrent uncomplicated adrenal cysts should be considered as an effective alternative method when patients are frail or surgery fails to resolve the problem.
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BMJ case reports, Jan 31, 2014
We report a case of an 86-year-old female patient who presented with a septic, right ureteric obs... more We report a case of an 86-year-old female patient who presented with a septic, right ureteric obstruction, caused by a symptomatic Bochdalek hernia. The patient was initially managed with percutaneous nephrostomy and final treatment was achieved by placement of an external-internal nephroureteral double pigtail.
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Leukemia Research, 2009
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Blood, 2009
Thrombocytopenia is a frequent symptom and clinical challenge in patients with myelodysplastic sy... more Thrombocytopenia is a frequent symptom and clinical challenge in patients with myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Eltrombopag is a small molecule thrombopoietin receptor agonist that might be a new option to treat thrombocytopenia in these diseases, provided that it does not stimulate malignant hematopoiesis. In this work, we studied the effects of Eltrombopag on proliferation, apoptosis, differentiation, colony formation, and malignant self-renewal of bone marrow mononuclear cells of patients with AML and MDS. Malignant bone marrow mononuclear cells did not show increased proliferation, or increased clonogenic capacity at concentrations of Eltrombopag ranging from 0.1 to 30 μg/mL. On the contrary, we observed a moderate, statistically nonsignificant (P = .18), decrease of numbers of malignant cells (mean, 56%; SD, 28%). Eltrombopag neither led to increased 5-bromo-2-deoxyuridine incorporation, decreased apoptosis, an increase of malignant self-renewal,...
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Insights into Imaging, 2020
Gastrointestinal tract (GIT) perforation is a common medical emergency associated with considerab... more Gastrointestinal tract (GIT) perforation is a common medical emergency associated with considerable mortality, ranging from 30 to 50%. Clinical presentation varies: oesophageal perforations can present with acute chest pain, odynophagia and vomiting, gastroduodenal perforations with acute severe abdominal pain, while colonic perforations tend to follow a slower progression course with secondary bacterial peritonitis or localised abscesses. A subset of patients may present with delayed symptoms, abscess mimicking an abdominal mass, or with sepsis.Direct multidetector computed tomography (MDCT) findings support the diagnosis and localise the perforation site while ancillary findings may suggest underlying conditions that need further investigation following primary repair of ruptured bowel. MDCT findings include extraluminal gas, visible bowel wall discontinuity, extraluminal contrast, bowel wall thickening, abnormal mural enhancement, localised fat stranding and/or free fluid, as wel...
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Applied Radiology
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Poster: "ECR 2017 / C-0620 / Pediatric intra-peritoneal abdominal cystic lesions: diagnosis ... more Poster: "ECR 2017 / C-0620 / Pediatric intra-peritoneal abdominal cystic lesions: diagnosis based on location and multimodality imaging characteristics" by: "A. Kozana, V. Fragkiadoulaki, M. Raissaki; Heraklion/GR"
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Papers by Androniki Kozana