Background Magnesium (Mg) is the second most abundant intracellular cation. Ionized Mg is the onl... more Background Magnesium (Mg) is the second most abundant intracellular cation. Ionized Mg is the only active form of Mg. The concentration of ionized Mg could be a potentially novel biomarker for anxiety and depression. Aim The aim of this study was to assess the serum concentration of ionized Mg and its correlation with biomarkers of oxidative stress and inflammation in patients with anxiety and depression. Methods In this study included 93 respondents were divided into 3 groups: C (control group—18 respondents); A (patients with anxiety disorder, dissociative/conversion disorders and somatoform disorders—36 patients); D (patients with depression—39 patients). Clinical diagnosis was based on ICD-10 criteria. Blood samples were used for standard laboratory analysis, ionized Mg analysis, oxidative stress, and inflammatory parameters. Results Statistical significance was recorded between healthy volunteers and patients (anxiety/depression) in ionized Mg values. In anxious patients, malondialdehyde (MDA) had a positive correlation between the parameters of oxidative stress with ionized Mg. In depressive patients, MDA had a positive correlation, and glutathione peroxidase 1 (GPX1) a negative correlation with the concentration of ionized Mg. Conclusion Ionized Mg and its correlation with parameters of oxidative stress could be potential biomarkers in anxious and depressive patients.
Psihomotorna agitacija ( PMA) ili psihomotorni nemir je stanje koje karakteriše uznemirenost, uz... more Psihomotorna agitacija ( PMA) ili psihomotorni nemir je stanje koje karakteriše uznemirenost, uzbuđenje, oslabljena kontrola ponašanja, ubrzana motorika, površan verbalni kontakt i tendencija impulsivnog reagovanja. U praksi je najvažnije otkriti epizode psihomotorne agitacije u njihovoj najranijoj manifestaciji kako bi se izbeglo usložnjavanje simptoma i sprečile brojne zdravstvene, pravne i ekonomske posledice koje neblagovremeno prepoznavanje sobom nosi. Psihomotorna agitacija i delirijum mogu biti jedan od simptoma COVID 19 infekcije. U tom kontekstu (interakcije sa antivirusnom i antimalaričnom th koja se koristi u lečenju covid infekcije i komplikacija same virusne infekcije) razmatramo terapiju agitacije kao stanja koje zahteva urgentni tretman.
The objective was to provide population-based data on depression, anxiety, and stress in parents ... more The objective was to provide population-based data on depression, anxiety, and stress in parents of young children with epilepsy and to compare findings with those of parents of developmental-, age-, and gender-matched children with nonepilepsy-related neurodisability (neurological and/or neurodevelopmental concerns). The parents (mothers and fathers) of 47 (89% ascertainment) young children (1-7years) with epilepsy in a defined geographical area of the UK completed the Depression Anxiety Stress Scales - Short Form (DASS-21), a screening measure for depression, anxiety, and stress. The responses of parents of children with epilepsy were compared with parents of developmental-, age-, and gender-matched children with nonepilepsy-related neurodisability (n=48). Factors associated with parental symptoms were analyzed using regression. In the group with epilepsy, 47 mothers and 39 fathers completed the DASS-21. Seventy-two percent of mothers scored in the at-risk range on at least one DA...
Background: The outbreak of the COVID-19 pandemic has affected the mental health of population wo... more Background: The outbreak of the COVID-19 pandemic has affected the mental health of population worldwide. Aim: Assessment of risk factors for symptoms of anxiety, depression, and stress during the first wave of the COVID-19 pandemic. Methods: An online survey including 161 participants was conducted in a population of both healthy participants and people who tested positive to COVID-19. The survey collected sociodemographic data, knowledge about the pandemic, psychological impact, and mental health status of the participants. The psychological impact on mental health status was assessed using the Depression, Anxiety, and Stress Scale (DASS-21). Logistic regression was used to determine the risk factors that increased the likelihood of having symptoms of depression, anxiety and stress. Results: A total of 63.8 % of participants showed symptoms of anxiety, with 31.6% showing moderate symptoms of anxiety. Symptoms of depression were found in 44.1% of the sample, with 23.7% showing mode...
International Journal of Environmental Research and Public Health
This study examined (1) the availability and content of national CPGs for treatment of peripartum... more This study examined (1) the availability and content of national CPGs for treatment of peripartum depression, including comorbid anxiety, with antidepressants and other psychotropics across Europe and (2) antidepressant and other psychotropic utilization data as an indicator of prescribers’ compliance to the guidelines. We conducted a search using Medline and the Guidelines International Network database, combined with direct e-mail contact with national Riseup-PPD COST ACTION members and researchers within psychiatry. Of the 48 European countries examined, we screened 41 records and included 14 of them for full-text evaluation. After exclusion of ineligible and duplicate records, we included 12 CPGs. Multiple CPGs recommend antidepressant initiation or continuation based on maternal disease severity, non-response to first-line non-pharmacological interventions, and after risk-benefit assessment. Advice on treatment of comorbid anxiety is largely missing or unspecific. Antidepressan...
Background Magnesium (Mg) is the second most abundant intracellular cation. Ionized Mg is the onl... more Background Magnesium (Mg) is the second most abundant intracellular cation. Ionized Mg is the only active form of Mg. The concentration of ionized Mg could be a potentially novel biomarker for anxiety and depression. Aim The aim of this study was to assess the serum concentration of ionized Mg and its correlation with biomarkers of oxidative stress and inflammation in patients with anxiety and depression. Methods In this study included 93 respondents were divided into 3 groups: C (control group—18 respondents); A (patients with anxiety disorder, dissociative/conversion disorders and somatoform disorders—36 patients); D (patients with depression—39 patients). Clinical diagnosis was based on ICD-10 criteria. Blood samples were used for standard laboratory analysis, ionized Mg analysis, oxidative stress, and inflammatory parameters. Results Statistical significance was recorded between healthy volunteers and patients (anxiety/depression) in ionized Mg values. In anxious patients, malondialdehyde (MDA) had a positive correlation between the parameters of oxidative stress with ionized Mg. In depressive patients, MDA had a positive correlation, and glutathione peroxidase 1 (GPX1) a negative correlation with the concentration of ionized Mg. Conclusion Ionized Mg and its correlation with parameters of oxidative stress could be potential biomarkers in anxious and depressive patients.
Psihomotorna agitacija ( PMA) ili psihomotorni nemir je stanje koje karakteriše uznemirenost, uz... more Psihomotorna agitacija ( PMA) ili psihomotorni nemir je stanje koje karakteriše uznemirenost, uzbuđenje, oslabljena kontrola ponašanja, ubrzana motorika, površan verbalni kontakt i tendencija impulsivnog reagovanja. U praksi je najvažnije otkriti epizode psihomotorne agitacije u njihovoj najranijoj manifestaciji kako bi se izbeglo usložnjavanje simptoma i sprečile brojne zdravstvene, pravne i ekonomske posledice koje neblagovremeno prepoznavanje sobom nosi. Psihomotorna agitacija i delirijum mogu biti jedan od simptoma COVID 19 infekcije. U tom kontekstu (interakcije sa antivirusnom i antimalaričnom th koja se koristi u lečenju covid infekcije i komplikacija same virusne infekcije) razmatramo terapiju agitacije kao stanja koje zahteva urgentni tretman.
The objective was to provide population-based data on depression, anxiety, and stress in parents ... more The objective was to provide population-based data on depression, anxiety, and stress in parents of young children with epilepsy and to compare findings with those of parents of developmental-, age-, and gender-matched children with nonepilepsy-related neurodisability (neurological and/or neurodevelopmental concerns). The parents (mothers and fathers) of 47 (89% ascertainment) young children (1-7years) with epilepsy in a defined geographical area of the UK completed the Depression Anxiety Stress Scales - Short Form (DASS-21), a screening measure for depression, anxiety, and stress. The responses of parents of children with epilepsy were compared with parents of developmental-, age-, and gender-matched children with nonepilepsy-related neurodisability (n=48). Factors associated with parental symptoms were analyzed using regression. In the group with epilepsy, 47 mothers and 39 fathers completed the DASS-21. Seventy-two percent of mothers scored in the at-risk range on at least one DA...
Background: The outbreak of the COVID-19 pandemic has affected the mental health of population wo... more Background: The outbreak of the COVID-19 pandemic has affected the mental health of population worldwide. Aim: Assessment of risk factors for symptoms of anxiety, depression, and stress during the first wave of the COVID-19 pandemic. Methods: An online survey including 161 participants was conducted in a population of both healthy participants and people who tested positive to COVID-19. The survey collected sociodemographic data, knowledge about the pandemic, psychological impact, and mental health status of the participants. The psychological impact on mental health status was assessed using the Depression, Anxiety, and Stress Scale (DASS-21). Logistic regression was used to determine the risk factors that increased the likelihood of having symptoms of depression, anxiety and stress. Results: A total of 63.8 % of participants showed symptoms of anxiety, with 31.6% showing moderate symptoms of anxiety. Symptoms of depression were found in 44.1% of the sample, with 23.7% showing mode...
International Journal of Environmental Research and Public Health
This study examined (1) the availability and content of national CPGs for treatment of peripartum... more This study examined (1) the availability and content of national CPGs for treatment of peripartum depression, including comorbid anxiety, with antidepressants and other psychotropics across Europe and (2) antidepressant and other psychotropic utilization data as an indicator of prescribers’ compliance to the guidelines. We conducted a search using Medline and the Guidelines International Network database, combined with direct e-mail contact with national Riseup-PPD COST ACTION members and researchers within psychiatry. Of the 48 European countries examined, we screened 41 records and included 14 of them for full-text evaluation. After exclusion of ineligible and duplicate records, we included 12 CPGs. Multiple CPGs recommend antidepressant initiation or continuation based on maternal disease severity, non-response to first-line non-pharmacological interventions, and after risk-benefit assessment. Advice on treatment of comorbid anxiety is largely missing or unspecific. Antidepressan...
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