The prevalence of mental illnesses has significantly increased globally in recent decades due to ... more The prevalence of mental illnesses has significantly increased globally in recent decades due to multifactorial causes. Of these, schizophrenia and bipolar disorder, due to their high incidence and high associated disability, stand out. However, the effective treatments on these disorders are lagged behind their increased incidence. Melatonin, as an essential molecule in the regulation of sleep-wake rhythm and the naturally occurring antioxidant, has only received attention for the treatment of such psychiatric disorders in relation to its circadian rhythm regulation, but its overwhelming role as a regulator of oxidative stress that facilitates the amelioration of neuronal damage has not been addressed for this respect. In this communication, the novel aspects of melatonin on mental illnesses have been discussed. We provide the necessary literature to justify the beneficial roles and the mechanisms of melatonin to treat schizophrenia and bipolar disorder. These mechanisms include th...
This study investigated the effect of different cattle management strategies at farm (Intensive v... more This study investigated the effect of different cattle management strategies at farm (Intensive vs. Extensive) and during transport and lairage (mixing vs. non-mixing with unfamiliar animals) on the myofibrillar subproteome of Longissimus thoracis et lumborum (LTL) muscle of “Asturiana de los Valles” yearling bulls. It further aimed to study the relationships with beef quality traits including pH, color, and tenderness evaluated by Warner–Bratzler shear force (WBSF). Thus, comparative proteomics of the myofibrillar fraction along meat maturation (from 2 h to 14 days post-mortem) and different quality traits were analyzed. A total of 23 protein fragments corresponding to 21 unique proteins showed significant differences among the treatments (p < 0.05) due to any of the factors considered (Farm, Transport and Lairage, and post-mortem time ageing). The proteins belong to several biological pathways including three structural proteins (MYBPC2, TNNT3, and MYL1) and one metabolic enzym...
In the bioluminescent, marine dinoflagellate Lingulodinium polyedrum [syn. Gonyaulax polyedra ], ... more In the bioluminescent, marine dinoflagellate Lingulodinium polyedrum [syn. Gonyaulax polyedra ], light emission Is sensitive to oxidative stress in a dual way: (a) The nocturnal glow maximum, which depends on the melatonin metabolite 5-methoxytryptamine (5-MT), is decreased by 5-MT depletion following oxidation of its precursor melatonin, which easily undergoes radical reactions; attenuations of the glow maximum are typical for sublethal oxidative stress, (b) Since luciferin availability is triggered by proton translocation to the scintillons (bioluminescent microsources which form cytoplasmic intrusions into acidic vacuoles), lethal oxidative stress causes strong rises in bioluminescence ("dying peaks") as a consequence of cytoplasmic acidification, which results from impaired proton pumping into vacuoles under ATP deficiency and/or proton leakage through damaged membranes. Sublethal concentrations of paraquat or buthionine sulfoximine decrease the circadian glow peak, in...
Metabolic syndrome is a global health problem in adults and its prevalence among children and ado... more Metabolic syndrome is a global health problem in adults and its prevalence among children and adolescents is rising. It is strongly linked to a lifestyle with high-caloric food, which causes obesity and lipid metabolism anomalies. Molecular damage due to excessive oxidative stress plays a major role during the development of metabolic syndrome complications. Among the different hormones, melatonin presents strong antioxidant properties, and it is used to treat metabolic diseases. However, there is not a consensus about its use as a metabolic syndrome treatment. The aim of this study was to identify melatonin effects in a metabolic syndrome model. Golden hamsters were fed with 60% fructose-enriched food to induce metabolic syndrome and were compared to hamsters fed with regular chow diet. Both groups were also treated with melatonin. Fructose-fed hamsters showed altered blood lipid levels (increased cholesterol and LDL) and phenotypes restored with the melatonin treatment. The Harder...
Despite efforts to curb the incidence of obesity and its comorbidities, this condition remains th... more Despite efforts to curb the incidence of obesity and its comorbidities, this condition remains the fifth leading cause of death worldwide. To identify ways to reduce this global effect, we investigated the actions of daily melatonin administration on oxidative stress parameters and autophagic processes as a possible treatment of obesity in ob/ob mice. The involvement of melatonin in many physiological functions, such as the regulation of seasonal body weight variation, glucose uptake, or adiposity, and the role of this indoleamine as an essential antioxidant, has become the focus of numerous anti-obesity studies. Here, we examined the oxidative status in the livers of obese melatonin-treated and untreated mice, observing a decrease in the oxidative stress levels through elevated catalase activity. ROS-mediated autophagy was downregulated in the liver of melatonin-treated animals and was accompanied by significant accumulation of p62. Autophagy is closely associated with adipogenesis; in this study, we report that melatonin-treated obese mice also showed reduced adiposity, as demonstrated by diminished body weight and reduced peroxisome proliferator-activated receptor gamma expression. Based on these factors, it is reasonable to assume that oxidative stress and autophagy play important roles in obesity, and therefore, melatonin could be an interesting target molecule for the development of a potential therapeutic agent to curb body weight.
The diversity between the muscle cellular interactome of dependent and independent elderly people... more The diversity between the muscle cellular interactome of dependent and independent elderly people is based on the interrelationships established between different cellular mechanisms, and alteration of this balance modulates cellular activity in muscle tissue with important functional implications.
The prevalence of mental illnesses has significantly increased globally in recent decades due to ... more The prevalence of mental illnesses has significantly increased globally in recent decades due to multifactorial causes. Of these, schizophrenia and bipolar disorder, due to their high incidence and high associated disability, stand out. However, the effective treatments on these disorders are lagged behind their increased incidence. Melatonin, as an essential molecule in the regulation of sleep-wake rhythm and the naturally occurring antioxidant, has only received attention for the treatment of such psychiatric disorders in relation to its circadian rhythm regulation, but its overwhelming role as a regulator of oxidative stress that facilitates the amelioration of neuronal damage has not been addressed for this respect. In this communication, the novel aspects of melatonin on mental illnesses have been discussed. We provide the necessary literature to justify the beneficial roles and the mechanisms of melatonin to treat schizophrenia and bipolar disorder. These mechanisms include th...
This study investigated the effect of different cattle management strategies at farm (Intensive v... more This study investigated the effect of different cattle management strategies at farm (Intensive vs. Extensive) and during transport and lairage (mixing vs. non-mixing with unfamiliar animals) on the myofibrillar subproteome of Longissimus thoracis et lumborum (LTL) muscle of “Asturiana de los Valles” yearling bulls. It further aimed to study the relationships with beef quality traits including pH, color, and tenderness evaluated by Warner–Bratzler shear force (WBSF). Thus, comparative proteomics of the myofibrillar fraction along meat maturation (from 2 h to 14 days post-mortem) and different quality traits were analyzed. A total of 23 protein fragments corresponding to 21 unique proteins showed significant differences among the treatments (p < 0.05) due to any of the factors considered (Farm, Transport and Lairage, and post-mortem time ageing). The proteins belong to several biological pathways including three structural proteins (MYBPC2, TNNT3, and MYL1) and one metabolic enzym...
In the bioluminescent, marine dinoflagellate Lingulodinium polyedrum [syn. Gonyaulax polyedra ], ... more In the bioluminescent, marine dinoflagellate Lingulodinium polyedrum [syn. Gonyaulax polyedra ], light emission Is sensitive to oxidative stress in a dual way: (a) The nocturnal glow maximum, which depends on the melatonin metabolite 5-methoxytryptamine (5-MT), is decreased by 5-MT depletion following oxidation of its precursor melatonin, which easily undergoes radical reactions; attenuations of the glow maximum are typical for sublethal oxidative stress, (b) Since luciferin availability is triggered by proton translocation to the scintillons (bioluminescent microsources which form cytoplasmic intrusions into acidic vacuoles), lethal oxidative stress causes strong rises in bioluminescence ("dying peaks") as a consequence of cytoplasmic acidification, which results from impaired proton pumping into vacuoles under ATP deficiency and/or proton leakage through damaged membranes. Sublethal concentrations of paraquat or buthionine sulfoximine decrease the circadian glow peak, in...
Metabolic syndrome is a global health problem in adults and its prevalence among children and ado... more Metabolic syndrome is a global health problem in adults and its prevalence among children and adolescents is rising. It is strongly linked to a lifestyle with high-caloric food, which causes obesity and lipid metabolism anomalies. Molecular damage due to excessive oxidative stress plays a major role during the development of metabolic syndrome complications. Among the different hormones, melatonin presents strong antioxidant properties, and it is used to treat metabolic diseases. However, there is not a consensus about its use as a metabolic syndrome treatment. The aim of this study was to identify melatonin effects in a metabolic syndrome model. Golden hamsters were fed with 60% fructose-enriched food to induce metabolic syndrome and were compared to hamsters fed with regular chow diet. Both groups were also treated with melatonin. Fructose-fed hamsters showed altered blood lipid levels (increased cholesterol and LDL) and phenotypes restored with the melatonin treatment. The Harder...
Despite efforts to curb the incidence of obesity and its comorbidities, this condition remains th... more Despite efforts to curb the incidence of obesity and its comorbidities, this condition remains the fifth leading cause of death worldwide. To identify ways to reduce this global effect, we investigated the actions of daily melatonin administration on oxidative stress parameters and autophagic processes as a possible treatment of obesity in ob/ob mice. The involvement of melatonin in many physiological functions, such as the regulation of seasonal body weight variation, glucose uptake, or adiposity, and the role of this indoleamine as an essential antioxidant, has become the focus of numerous anti-obesity studies. Here, we examined the oxidative status in the livers of obese melatonin-treated and untreated mice, observing a decrease in the oxidative stress levels through elevated catalase activity. ROS-mediated autophagy was downregulated in the liver of melatonin-treated animals and was accompanied by significant accumulation of p62. Autophagy is closely associated with adipogenesis; in this study, we report that melatonin-treated obese mice also showed reduced adiposity, as demonstrated by diminished body weight and reduced peroxisome proliferator-activated receptor gamma expression. Based on these factors, it is reasonable to assume that oxidative stress and autophagy play important roles in obesity, and therefore, melatonin could be an interesting target molecule for the development of a potential therapeutic agent to curb body weight.
The diversity between the muscle cellular interactome of dependent and independent elderly people... more The diversity between the muscle cellular interactome of dependent and independent elderly people is based on the interrelationships established between different cellular mechanisms, and alteration of this balance modulates cellular activity in muscle tissue with important functional implications.
Uploads