Background There is a lack of data on the prevalence of PCOS and its phenotype in many geographic... more Background There is a lack of data on the prevalence of PCOS and its phenotype in many geographic regions. Siberia is a unique region of the Russian Federation with a multi-raced population living in similar geographic and socio-economic conditions for centuries. Therefore, we considered this population optimal for epidemiological research. Objectives To determine the prevalence of PCOS and the PCOS phenotypes in unselected women in the Eastern Siberia region. Population: We performed the institution-based, cross-sectional Eastern Siberia PCOS Epidemiology & Phenotype (ESPEP) Study during 2016-2019 (СlinicalTrials.gov ID: NCT05194384) and recruited 1148 premenopausal women aged 34.3±6.3 yrs., of which 63.2% were Caucasians, 27.6% Asians, and 9.2% Mixed-race. All subjects provided written informed consent. Exclusion criteria were: current pregnancy or lactation, history of hysterectomy, bilateral oophorectomy, endometrial ablation, uterine artery embolization; and current or previous...
AIM: To estimate clinical manifestation of decreased ovarian reserve in women of reproductive age... more AIM: To estimate clinical manifestation of decreased ovarian reserve in women of reproductive age from Eastern Siberia. MATERIAL AND METHODS: A total of 1119 women aged 18 to 40 years who underwent an annual preventive medical examination at their place of work were invited to participate in a cross-sectional study performed in 20172019 in Irkutsk Region and Buryat Republic (Russia). Among the 1119 women, 907 aged 31.785.13 years were included in the study, after which clinical, instrumental, and laboratory research methods and statistical analysis were utilized. Among the 907 women included in the study, 117 (12.9%) had 5 follicles per ovary and were diagnosed with decreased ovarian reserve (DOR). The laboratory study showed that 56 of the 117 (47.8%) women had an antimullerian hormone (AMH) level below 1.2 ng/mL, the average value of which was 0.530.43 ng/mL. RESULTS: In women with reduced AMH levels, a shortening of the menstrual cycle (p=0.0187) and high parity were observed. Mo...
Currently, hyperprolactinemia is considered as a condition to be excluded during the diagnosis of... more Currently, hyperprolactinemia is considered as a condition to be excluded during the diagnosis of polycystic ovarian syndrome (PCOS), because it often demonstrates clinical signs similar to PCOS. However, some publications have reported “the prevalence of hyperprolactinemia in PCOS,” which does not agree with the statement above statement. The publications presented in this review demonstrate conflicting approaches to considering the association of hyperprolactinemia and PCOS. On the one hand, the current consensus on the diagnosis of PCOS assumes the exclusion of patients with hyperprolactinemia, and on the other hand, some authors consider hyperprolactinemia as an acceptable condition and estimate its prevalence in PCOS. Based on the analysis of the literature, we have demonstrated a contradictory attitude towards the association between hyperprolactinemia and PCOS. To overcome the contradiction, we consider it appropriate to use the term "potential PCOS" before the fina...
The paper presents the main principles of applying Research Electronic Data Capture (REDCap) syst... more The paper presents the main principles of applying Research Electronic Data Capture (REDCap) system to data collection and data storage in population-based biomedical studies. Advantages and limitations of using REDCap as well as possibilities for obtaining intermediate reports, descriptive statistics and data management are presented from the point of view of research project logistics using the Eastern Siberia PCOS Epidemiology & Phenotype (ESPEP) population-based study as an example.
Background. Searching for new strategies for the rehabilitation of adolescents with obesity and c... more Background. Searching for new strategies for the rehabilitation of adolescents with obesity and comorbid arterial hypertension (AHT) before significant pathological changes development in the cardiovascular system remains the urgent challenge. Objective. The aim of the study was to examine the effect of interval hypoxic training (IHT) on blood pressure (BP) levels in adolescents with overweight / obesity and comorbid AHT. Methods. Adolescents aged 14-17 years with body mass index SDS ≥ 1 and grade I AHT (mean level of systolic and/or diastolic BP ≥ 95th percentile for population of corresponding age, sex and height) have been randomized to the group «aerobic training» (treadmill walking) and “aerobic training + IHT” (usage of hypoxicator in intermittent operation cycles). All patients were on subcaloric diet (10% reduction in caloric intake for given age). Primary outcome measure was the difference between groups on systolic/diastolic BP levels according to 24-hour BP monitoring aft...
BACKGROUND: The stigma of people living with HIV (PLHIV) remains an urgent problem of modern scie... more BACKGROUND: The stigma of people living with HIV (PLHIV) remains an urgent problem of modern science. Meanwhile, it can be stated that there is a lack of methods used to study stigmatization. AIM: The aim of this study was to evaluate the stigmatization of PLHIV among healthcare workers of the obstetric and gynecological service. MATERIALS AND METHODS: The study included 232 doctors and nurses of the obstetric and gynecological service and was conducted from April to November 2018. We adapted the Questionnaire for Doctors and Nurses Views on People Living with HIV/AIDS and the Comprehensive Health Staff Questionnaire (for sentinel surveillance) for this study. RESULTS: We have studied the current level of awareness of healthcare workers of the obstetric and gynecological service regarding the ways of HIV transmission and methods of treatment. The contradictory attitudes of medical workers towards PLHIV were considered. On the one hand, medical professionals believe that, regardless ...
This study presents a step-by-step Russian adaptation of the Questionnaire for doctors and nurses... more This study presents a step-by-step Russian adaptation of the Questionnaire for doctors and nurses views on people living with HIV/AIDS and Comprehensive Health Staff Questionnaire (for sentinel surveillance) for Russian-speaking audience of medical professionals. Based on the analysis of foreign and domestic studies, it is concluded that no specialized questionnaires on the stigmatization of people living with HIV (PLHIV) for health professionals are available. A sample of 250 medical workers of different levels (doctors and nurses) of Eastern Siberia is used for the step-by-step adaptation of questionnaires indicating the procedures for the compliance with the content validity, criteria validity, reliability, and reproducibility. Overall, the findings of this study indicate that the level of reliability of the Russian language version of the Questionnaire for doctors and nurses views on people living with HIV/ AIDS is sufficient: Cronbachs alpha for this questionnaire was 0.72, and...
ABSTRACTAimTo establish reference intervals (RI) for blood amino acids (AA) in healthy newborns o... more ABSTRACTAimTo establish reference intervals (RI) for blood amino acids (AA) in healthy newborns of North Asia measured by liquid chromatography tandem mass spectrometry (LC-MS/MS) and evaluate their differences from respective reference values for newborns from other populations.ObjectivesA cross-sectional study of 381 healthy newborns was conducted. De-identified dried blood spots annotated by age, birth-weight, and sex were obtained from 381 healthy newborns aged 0–7 days. Data was collected from April to May of 2020.MethodsDried blood spots collected from filtered paper were used to analyze and measure of 13 derivatized amino acids using LC-MS/MS method. Nonparametric statistical approaches were used to generate 2.5th–97.5th percentile distributions for newborns in North Asia in accordance with CLSI EP28-A3c.ResultsReference intervals (RI) for phenylalanine, tyrosine, citrulline, alanine, ornithine, proline in North Asian newborns differ slightly from those of newborns in other c...
Journal of Pharmaceutical Research International, 2020
Background: Hyperprolactinemia (HP) is a common endocrine gynecological disorder in women of repr... more Background: Hyperprolactinemia (HP) is a common endocrine gynecological disorder in women of reproductive age manifested with menstrual irregularity and sterility subfertility among the majority of women with this disorder. Objective: The aim of this study was to assess the endocrinal markers of inferility in premenopausal women with idiopathic hyperprolactinemia. Materials and Metahodology: The study included 82 women: 27 healthy women, 22 fertile women with idiopathic HP and 33 patients with endocrine sub fertility with idiopathic HP. All women underwent a standard history taking, clinical examinations. Lab tests were performed in all women and included the detection of the concentrations of prolactin, thyroid-stimulating hormone, thyroxine, triiodothyronine, cortisol, gonadotrophic hormones, testosterone, and estradiol by ELISA method. Results: The study results demonstrated that subfertile women with HP are characterized by an increase of follicle-stimulating hormone and fre...
The objective of this study was to determine uterine fibroids (UF) prevalence in the unselected (... more The objective of this study was to determine uterine fibroids (UF) prevalence in the unselected (medically unbiased) female population in the Eastern Siberia region, Russia, and to evaluate the significant risk factors. Methods and Results: The study included 2389 women aged from 18 to 80 yrs (mean age of 42.8±11.9 yrs). Subjects were evaluated consecutively by means of questionnaires, anthropometry, vital signs, gynecological examination, and pelvic ultrasound. We demonstrated 26.41% UF prevalence in the unselected female population from Eastern Siberia. We found that the single nodules predominate among all fibroids, with the types 3–5 and the size of either ≤1 cm or ≥4 cm as the most frequent variants. Our study confirmed that the prevalence of fibroids increases with age. The incidence of fibroids is significantly lower in women with the age at menarche of 15 years. We also have found that a BMI of more than 25 kg/m2, more than 4 pregnancies, and late menopause are risk factors ...
Background There is a lack of data on the prevalence of PCOS and its phenotype in many geographic... more Background There is a lack of data on the prevalence of PCOS and its phenotype in many geographic regions. Siberia is a unique region of the Russian Federation with a multi-raced population living in similar geographic and socio-economic conditions for centuries. Therefore, we considered this population optimal for epidemiological research. Objectives To determine the prevalence of PCOS and the PCOS phenotypes in unselected women in the Eastern Siberia region. Population: We performed the institution-based, cross-sectional Eastern Siberia PCOS Epidemiology & Phenotype (ESPEP) Study during 2016-2019 (СlinicalTrials.gov ID: NCT05194384) and recruited 1148 premenopausal women aged 34.3±6.3 yrs., of which 63.2% were Caucasians, 27.6% Asians, and 9.2% Mixed-race. All subjects provided written informed consent. Exclusion criteria were: current pregnancy or lactation, history of hysterectomy, bilateral oophorectomy, endometrial ablation, uterine artery embolization; and current or previous...
AIM: To estimate clinical manifestation of decreased ovarian reserve in women of reproductive age... more AIM: To estimate clinical manifestation of decreased ovarian reserve in women of reproductive age from Eastern Siberia. MATERIAL AND METHODS: A total of 1119 women aged 18 to 40 years who underwent an annual preventive medical examination at their place of work were invited to participate in a cross-sectional study performed in 20172019 in Irkutsk Region and Buryat Republic (Russia). Among the 1119 women, 907 aged 31.785.13 years were included in the study, after which clinical, instrumental, and laboratory research methods and statistical analysis were utilized. Among the 907 women included in the study, 117 (12.9%) had 5 follicles per ovary and were diagnosed with decreased ovarian reserve (DOR). The laboratory study showed that 56 of the 117 (47.8%) women had an antimullerian hormone (AMH) level below 1.2 ng/mL, the average value of which was 0.530.43 ng/mL. RESULTS: In women with reduced AMH levels, a shortening of the menstrual cycle (p=0.0187) and high parity were observed. Mo...
Currently, hyperprolactinemia is considered as a condition to be excluded during the diagnosis of... more Currently, hyperprolactinemia is considered as a condition to be excluded during the diagnosis of polycystic ovarian syndrome (PCOS), because it often demonstrates clinical signs similar to PCOS. However, some publications have reported “the prevalence of hyperprolactinemia in PCOS,” which does not agree with the statement above statement. The publications presented in this review demonstrate conflicting approaches to considering the association of hyperprolactinemia and PCOS. On the one hand, the current consensus on the diagnosis of PCOS assumes the exclusion of patients with hyperprolactinemia, and on the other hand, some authors consider hyperprolactinemia as an acceptable condition and estimate its prevalence in PCOS. Based on the analysis of the literature, we have demonstrated a contradictory attitude towards the association between hyperprolactinemia and PCOS. To overcome the contradiction, we consider it appropriate to use the term "potential PCOS" before the fina...
The paper presents the main principles of applying Research Electronic Data Capture (REDCap) syst... more The paper presents the main principles of applying Research Electronic Data Capture (REDCap) system to data collection and data storage in population-based biomedical studies. Advantages and limitations of using REDCap as well as possibilities for obtaining intermediate reports, descriptive statistics and data management are presented from the point of view of research project logistics using the Eastern Siberia PCOS Epidemiology & Phenotype (ESPEP) population-based study as an example.
Background. Searching for new strategies for the rehabilitation of adolescents with obesity and c... more Background. Searching for new strategies for the rehabilitation of adolescents with obesity and comorbid arterial hypertension (AHT) before significant pathological changes development in the cardiovascular system remains the urgent challenge. Objective. The aim of the study was to examine the effect of interval hypoxic training (IHT) on blood pressure (BP) levels in adolescents with overweight / obesity and comorbid AHT. Methods. Adolescents aged 14-17 years with body mass index SDS ≥ 1 and grade I AHT (mean level of systolic and/or diastolic BP ≥ 95th percentile for population of corresponding age, sex and height) have been randomized to the group «aerobic training» (treadmill walking) and “aerobic training + IHT” (usage of hypoxicator in intermittent operation cycles). All patients were on subcaloric diet (10% reduction in caloric intake for given age). Primary outcome measure was the difference between groups on systolic/diastolic BP levels according to 24-hour BP monitoring aft...
BACKGROUND: The stigma of people living with HIV (PLHIV) remains an urgent problem of modern scie... more BACKGROUND: The stigma of people living with HIV (PLHIV) remains an urgent problem of modern science. Meanwhile, it can be stated that there is a lack of methods used to study stigmatization. AIM: The aim of this study was to evaluate the stigmatization of PLHIV among healthcare workers of the obstetric and gynecological service. MATERIALS AND METHODS: The study included 232 doctors and nurses of the obstetric and gynecological service and was conducted from April to November 2018. We adapted the Questionnaire for Doctors and Nurses Views on People Living with HIV/AIDS and the Comprehensive Health Staff Questionnaire (for sentinel surveillance) for this study. RESULTS: We have studied the current level of awareness of healthcare workers of the obstetric and gynecological service regarding the ways of HIV transmission and methods of treatment. The contradictory attitudes of medical workers towards PLHIV were considered. On the one hand, medical professionals believe that, regardless ...
This study presents a step-by-step Russian adaptation of the Questionnaire for doctors and nurses... more This study presents a step-by-step Russian adaptation of the Questionnaire for doctors and nurses views on people living with HIV/AIDS and Comprehensive Health Staff Questionnaire (for sentinel surveillance) for Russian-speaking audience of medical professionals. Based on the analysis of foreign and domestic studies, it is concluded that no specialized questionnaires on the stigmatization of people living with HIV (PLHIV) for health professionals are available. A sample of 250 medical workers of different levels (doctors and nurses) of Eastern Siberia is used for the step-by-step adaptation of questionnaires indicating the procedures for the compliance with the content validity, criteria validity, reliability, and reproducibility. Overall, the findings of this study indicate that the level of reliability of the Russian language version of the Questionnaire for doctors and nurses views on people living with HIV/ AIDS is sufficient: Cronbachs alpha for this questionnaire was 0.72, and...
ABSTRACTAimTo establish reference intervals (RI) for blood amino acids (AA) in healthy newborns o... more ABSTRACTAimTo establish reference intervals (RI) for blood amino acids (AA) in healthy newborns of North Asia measured by liquid chromatography tandem mass spectrometry (LC-MS/MS) and evaluate their differences from respective reference values for newborns from other populations.ObjectivesA cross-sectional study of 381 healthy newborns was conducted. De-identified dried blood spots annotated by age, birth-weight, and sex were obtained from 381 healthy newborns aged 0–7 days. Data was collected from April to May of 2020.MethodsDried blood spots collected from filtered paper were used to analyze and measure of 13 derivatized amino acids using LC-MS/MS method. Nonparametric statistical approaches were used to generate 2.5th–97.5th percentile distributions for newborns in North Asia in accordance with CLSI EP28-A3c.ResultsReference intervals (RI) for phenylalanine, tyrosine, citrulline, alanine, ornithine, proline in North Asian newborns differ slightly from those of newborns in other c...
Journal of Pharmaceutical Research International, 2020
Background: Hyperprolactinemia (HP) is a common endocrine gynecological disorder in women of repr... more Background: Hyperprolactinemia (HP) is a common endocrine gynecological disorder in women of reproductive age manifested with menstrual irregularity and sterility subfertility among the majority of women with this disorder. Objective: The aim of this study was to assess the endocrinal markers of inferility in premenopausal women with idiopathic hyperprolactinemia. Materials and Metahodology: The study included 82 women: 27 healthy women, 22 fertile women with idiopathic HP and 33 patients with endocrine sub fertility with idiopathic HP. All women underwent a standard history taking, clinical examinations. Lab tests were performed in all women and included the detection of the concentrations of prolactin, thyroid-stimulating hormone, thyroxine, triiodothyronine, cortisol, gonadotrophic hormones, testosterone, and estradiol by ELISA method. Results: The study results demonstrated that subfertile women with HP are characterized by an increase of follicle-stimulating hormone and fre...
The objective of this study was to determine uterine fibroids (UF) prevalence in the unselected (... more The objective of this study was to determine uterine fibroids (UF) prevalence in the unselected (medically unbiased) female population in the Eastern Siberia region, Russia, and to evaluate the significant risk factors. Methods and Results: The study included 2389 women aged from 18 to 80 yrs (mean age of 42.8±11.9 yrs). Subjects were evaluated consecutively by means of questionnaires, anthropometry, vital signs, gynecological examination, and pelvic ultrasound. We demonstrated 26.41% UF prevalence in the unselected female population from Eastern Siberia. We found that the single nodules predominate among all fibroids, with the types 3–5 and the size of either ≤1 cm or ≥4 cm as the most frequent variants. Our study confirmed that the prevalence of fibroids increases with age. The incidence of fibroids is significantly lower in women with the age at menarche of 15 years. We also have found that a BMI of more than 25 kg/m2, more than 4 pregnancies, and late menopause are risk factors ...
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