A pseudo-line source has been realized by using an accelerator based DT point neutron source. The... more A pseudo-line source has been realized by using an accelerator based DT point neutron source. The pseudo-line source is obtained by time averaging of continuously moving point source or by superposition of finely distributed point sources. The line source ...
Page 1. Kinetic modelling of the active transport of copper(II) across liquid membranes usingthio... more Page 1. Kinetic modelling of the active transport of copper(II) across liquid membranes usingthiourea derivatives immobilized on microporous hydrophobic supports Fatima Z. El Aamrani, Anil Kumar¤ and Ana M. Sastre* Department of Chemical Engineering, Universitat ...
In all, 19 research subjects, with current histories of frequent cocaine use, were exposed to coc... more In all, 19 research subjects, with current histories of frequent cocaine use, were exposed to cocaine-related cues to elicit drug craving. We measured the change of occupancy of dopamine at D2-like receptors with positron emission tomography (PET) and inferred a change of intrasynaptic dopamine (endogenous dopamine release), based on the displacement of radiotracer [(11)C]raclopride. Receptor occupancy by dopamine increased significantly in putamen of participants who reported cue-elicited craving compared to those who did not. Further, the intensity of craving was positively correlated with the increase in dopamine receptor occupancy in the putamen. These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine.
Abstract Synthesis of 12-aryl-8, 9, 10, 12-tetrahydro-benzo [a] xanthen-11-ones was achieved by o... more Abstract Synthesis of 12-aryl-8, 9, 10, 12-tetrahydro-benzo [a] xanthen-11-ones was achieved by one-pot condensation of β-naphthol, substituted benzaldehydes, and 1, 3-dicarbonyl compounds catalyzed by Sc (OTf) 3 under microwave irradiation in excellent isolated yields. The catalyst was recycled up to four cycles with no appreciable loss in catalytic activity. The compounds were evaluated for Src kinase activity and anticancer activity. Graphical abstract
The variation in transposition history of different Ty1-copia group LTR retrotransposons in the s... more The variation in transposition history of different Ty1-copia group LTR retrotransposons in the species lineages of the Pisum genus has been investigated. A heterogeneous population of Ty1-copia elements was isolated by degenerate PCR and two of these (Tps12 and Tps19) were selected on the basis of their copy number and sequence conservation between closely related species for further in-depth study of their transpositional history in Pisum species. The insertional polymorphism of these elements and the previously characterised PDR1 element was studied by sequence-specific amplification polymorphism (SSAP). Each of these elements reveals a unique transpositional history within 55 diverse Pisum accessions. Phylogenetic trees based on the SSAP data show that SSAP markers for individual elements are able to resolve different species lineages within the Pisum genus. Finally, the SSAP data from all of these retrotransposon markers were combined to reveal a detailed picture of the intra and interspecies relationships within Pisum.
Seed development is a complex process controlled by temporal and spatial expression of many trans... more Seed development is a complex process controlled by temporal and spatial expression of many transcription factors (TF) inside the developing seed. In the present study, transcript profiles of all the 30 members of rice DofTFs from flowering to seed development stages were analyzed. It was found that 16 Dof genes besides a previously characterized Dof gene…
A pseudo-line source has been realized by using an accelerator based DT point neutron source. The... more A pseudo-line source has been realized by using an accelerator based DT point neutron source. The pseudo-line source is obtained by time averaging of continuously moving point source or by superposition of finely distributed point sources. The line source ...
Page 1. Kinetic modelling of the active transport of copper(II) across liquid membranes usingthio... more Page 1. Kinetic modelling of the active transport of copper(II) across liquid membranes usingthiourea derivatives immobilized on microporous hydrophobic supports Fatima Z. El Aamrani, Anil Kumar¤ and Ana M. Sastre* Department of Chemical Engineering, Universitat ...
In all, 19 research subjects, with current histories of frequent cocaine use, were exposed to coc... more In all, 19 research subjects, with current histories of frequent cocaine use, were exposed to cocaine-related cues to elicit drug craving. We measured the change of occupancy of dopamine at D2-like receptors with positron emission tomography (PET) and inferred a change of intrasynaptic dopamine (endogenous dopamine release), based on the displacement of radiotracer [(11)C]raclopride. Receptor occupancy by dopamine increased significantly in putamen of participants who reported cue-elicited craving compared to those who did not. Further, the intensity of craving was positively correlated with the increase in dopamine receptor occupancy in the putamen. These results provide direct evidence that occupancy of dopamine receptors in human dorsal striatum increased in proportion to subjective craving, presumably because of increased release of intrasynaptic dopamine.
Abstract Synthesis of 12-aryl-8, 9, 10, 12-tetrahydro-benzo [a] xanthen-11-ones was achieved by o... more Abstract Synthesis of 12-aryl-8, 9, 10, 12-tetrahydro-benzo [a] xanthen-11-ones was achieved by one-pot condensation of β-naphthol, substituted benzaldehydes, and 1, 3-dicarbonyl compounds catalyzed by Sc (OTf) 3 under microwave irradiation in excellent isolated yields. The catalyst was recycled up to four cycles with no appreciable loss in catalytic activity. The compounds were evaluated for Src kinase activity and anticancer activity. Graphical abstract
The variation in transposition history of different Ty1-copia group LTR retrotransposons in the s... more The variation in transposition history of different Ty1-copia group LTR retrotransposons in the species lineages of the Pisum genus has been investigated. A heterogeneous population of Ty1-copia elements was isolated by degenerate PCR and two of these (Tps12 and Tps19) were selected on the basis of their copy number and sequence conservation between closely related species for further in-depth study of their transpositional history in Pisum species. The insertional polymorphism of these elements and the previously characterised PDR1 element was studied by sequence-specific amplification polymorphism (SSAP). Each of these elements reveals a unique transpositional history within 55 diverse Pisum accessions. Phylogenetic trees based on the SSAP data show that SSAP markers for individual elements are able to resolve different species lineages within the Pisum genus. Finally, the SSAP data from all of these retrotransposon markers were combined to reveal a detailed picture of the intra and interspecies relationships within Pisum.
Seed development is a complex process controlled by temporal and spatial expression of many trans... more Seed development is a complex process controlled by temporal and spatial expression of many transcription factors (TF) inside the developing seed. In the present study, transcript profiles of all the 30 members of rice DofTFs from flowering to seed development stages were analyzed. It was found that 16 Dof genes besides a previously characterized Dof gene…
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