Papers by Sanghamitra Pati
Scientific reports, Jun 4, 2024
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Primary Health Care Research & Development, 2019
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Malaria Journal
Background Information on the foci of Plasmodium species infections is essential for any country ... more Background Information on the foci of Plasmodium species infections is essential for any country heading towards elimination. Odisha, one of the malaria-endemic states of India is targeting elimination of malaria by 2030. To support decision-making regarding targeted intervention, the distribution of Plasmodium species infections was investigated in hard-to-reach areas where a special malaria elimination drive, namely Durgama Anchalare Malaria Nirakaran (DAMaN) began in 2017. Methods A cross-sectional survey was conducted in 2228 households during July to November 2019 in six districts, to evaluate the occurrence of Plasmodium species. The species were identified by polymerase chain reaction (PCR) followed by sequencing, in case of Plasmodium ovale. Results Of the 3557 blood specimens tested, malaria infection was detected in 282 (7.8%) specimens by PCR. Of the total positive samples, 14.1% were P. ovale spp. and 10.3% were Plasmodium malariae infections. The majority of P. ovale sp...
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Frontiers in Microbiology
The Global Health Sector Strategy on viral hepatitis (2016–2021) endorsed by the World Health Ass... more The Global Health Sector Strategy on viral hepatitis (2016–2021) endorsed by the World Health Assembly in 2016, called for the elimination of viral hepatitis as a public health threat by 2030. Odisha, an eastern state of India, has the third-highest percentage of tribal population in the country and limited information is available regarding the prevalence of HBsAg among them. The present study was undertaken to estimate the seroprevalence of hepatitis B surface antigen as well as HBV DNA almost after 12 years of the first prevalence study of HBsAg among the tribal community of Odisha. The present study attempted to estimate the prevalence of HBsAg among the 35 Scheduled tribal (ST) communities and 5 Particularly Vulnerable Tribal Group (PVTG) using the 2,737 number of sera collected as part of a statewide COVID-19 serosurvey, among the tribal populations of Odisha (residing in 7 districts) aged 6–75 years. HBsAg positivity ranged between 1.79 and 2.94% across various age groups. 42...
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Frontiers in Public Health
Two vaccines, namely BBV-152 (COVAXIN®) and AZD1222 (COVISHIELD™), were deployed against SARS-CoV... more Two vaccines, namely BBV-152 (COVAXIN®) and AZD1222 (COVISHIELD™), were deployed against SARS-CoV-2 in India from January 16, 2021. Frontline health care workers were vaccinated first, followed by the adult population. However, limited data on vaccine effectiveness are available for the population of India. Therefore, we aimed to evaluate the effectiveness of two doses of each of these two common vaccines against COVID-19 infection among hospitalized patients with pulmonary conditions. We adopted a test-negative case–control design and recruited a sample of adults who were admitted to one of six tertiary care hospitals in Odisha. All participants were hospitalized patients with COVID-19-like pulmonary signs and symptoms. Participants who tested positive for SARS CoV-2 via RT-PCR were treated as cases, and those who tested negative were treated as controls. Logistic regression, adjusted for participants' age, sex, and number of comorbidities, was used to calculate the effectivene...
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Frontiers in Microbiology
BackgroundBrucellosis is a neglected zoonotic disease found predominantly in lower- and middle-in... more BackgroundBrucellosis is a neglected zoonotic disease found predominantly in lower- and middle-income countries (LMICs), causing significant public health concern in India. The objective of this study was to assess the prevalence of human brucellosis in Odisha, India among community members involved in animal husbandry as a common practice.MethodThis cross-sectional study included 817 adult participants from 11 districts in Odisha. Four districts from the Northern division, four districts from the Central division, and three districts from the Southern division were selected for the study. Blood samples were collected during a COVID-19 serosurvey in Odisha conducted from 1st to 17th September 2021. Immunoglobulin-G (IgG) antibodies were measured against Brucella using a commercial ELISA kit. Point estimates at 95% confidence intervals (CIs) and adjusted odds ratio were calculated.ResultsThe overall prevalence of anti-Brucella IgG antibodies was calculated at 16.65% (95% CI: 14.19–19...
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Malaria Journal
Background Haemoglobinopathies and G6PD deficiency are inherited disorders found mostly in malari... more Background Haemoglobinopathies and G6PD deficiency are inherited disorders found mostly in malaria-endemic areas among different tribal groups of India. However, epidemiological data specific to Particularly Vulnerable Tribal Groups (PVTGs), important for planning and implementing malaria programmes, is limited. Therefore, the present community-based study aimed to assess the prevalence of haemoglobinopathies and G6PD deficiency among the 13 PVTGs found in the state of Odisha, reporting the maximum malaria cases in the country. Methods This cross-sectional study was conducted from July 2018 to February 2019 in 12 districts, home to all 13 PVTGs, in an estimated sample size of 1461, selected two-stage sampling method. Detection of haemoglobinopathies was done by the variant analyser. Screening of G6PD deficiency was carried out using DPIP method followed by quantification using spectrophotometry. The PCR–RFLP technology was used to determine variant of G6PD deficiency and haplotype a...
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There is an uncertainty regarding the effect of the SARS-CoV-2 infection on patients with chronic... more There is an uncertainty regarding the effect of the SARS-CoV-2 infection on patients with chronic rheumatic diseases who are on immunosuppressive drugs. We did a multicentric cross sectional seroprevalence study were conducted in five different cities of India prior to COVID-19 immunization. Patients with a diagnosis of rheumatic disease and on DMARDs were included. Relatives of the patients, preferably staying in the same household with no known rheumatic diseases served as controls (subjects without disease). Serum IgG antibodies to SARS-CoV-2 Receptor Binding Domain (RBD) of the spike protein and nucleoprotein (NP) was assayed. Eight hundred eighty-nine sera (subjects with disease = 379 and in subjects without disease = 510) were assayed. IgG antibodies to either RBD and/or NP were positive in 135 (36%) subjects with disease as compared to 196 (38%) in subjects without disease. The seroprevalence to RBD and NP varied between different cities but was not significantly different be...
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BackgroundSnakebite envenoming (SBE) is an acute, life-threatening emergency in tropical and subt... more BackgroundSnakebite envenoming (SBE) is an acute, life-threatening emergency in tropical and subtropical countries. It is an occupational hazard and a major socioeconomic determinant. Limited awareness, superstitions, lack of trained health providers, poor utilization of anti-venom results in high mortality and morbidity. India is the snakebite capital of the world. Yet, information on awareness, knowledge, and perceptions about snakebite is limited. Data on capacity building of health systems and its potential impact is lacking. Recommended by the National Task Force on snakebite research in India, this protocol describes the National Snakebite Project aiming for capacity building of health systems on prevention and management of snakebite envenomation in Maharashtra and Odisha states.MethodsA cross-sectional, multi-centric study will be carried out in Shahapur, Aheri blocks of Maharashtra, and Khordha, Kasipur blocks of Odisha. The study has five phases: Phase I involves the colle...
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Frontiers in Molecular Biosciences, 2022
Multimorbidity, the simultaneous presence of two or more chronic diseases, affects the health car... more Multimorbidity, the simultaneous presence of two or more chronic diseases, affects the health care to a great extent. Its association with health care cost, more disability, and poor quality of life makes it a major public health risk. The matter of worry is that management of a multimorbid condition is complicated by the fact that multiple types of treatment may be required to treat different diseases at a time, and the interaction between some of the therapies can be detrimental. Understanding the causal factors of simultaneously occurring disease conditions and investigating the connected pathways involved in the whole process may resolve the complication. When different disease conditions present in an individual share common responsible factors, treatment strategies targeting at those common causes will certainly reduce the chance of development of multimorbidity occurring because of those factors. Metabolomics that can dig out the underlying metabolites/molecules of a medical ...
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Acta Scientific Women's Health, 2021
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PLOS ONE, 2021
Background Anthrax is a major but neglected zoonotic disease of public health concern in India wi... more Background Anthrax is a major but neglected zoonotic disease of public health concern in India with Odisha contributing a major share to the disease burden. Bacillus anthracis spores can be found naturally in soil and commonly affect both animals and humans around the world. Domestic and wild animals such as cattle, sheep, goats, and deer can become infected when they inhale or ingest spores from contaminated soil, plants, or water. Anthrax can be fatal if patients are not treated promptly with antibiotics. This protocol aims to describe the implementation and evaluation of the ‘One Health’ intervention model based on the principles of Theory of Change (ToC) to eliminate human anthrax from a tribal district in Odisha, India. Methods This study would test the effectiveness of a complex public health intervention package developed using the ToC framework for the elimination of human anthrax in Koraput district by a comparative analysis of baseline and end-line data. We plan to enroll ...
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Epidemiology and Infection, 2021
Cholera is one of the major public health problems in the state of Odisha, India since centuries.... more Cholera is one of the major public health problems in the state of Odisha, India since centuries. The current paper is a comprehensive report on epidemiology of cholera in Odisha, which was documented from 1993. PubMed and Web of Knowledge were searched for publications reporting cholera in Odisha during the period 1993–2015. The search was performed using the keywords ‘Odisha’ and/or ‘Orissa’ and ‘Cholera’. In addition, manual search was undertaken to find out relevant papers. During the study period, a total of 37 cholera outbreaks were reported with an average of >1.5 cholera outbreaks per year and case fatality ratio was 0.3%.Vibrio choleraeO1 Ogawa serotype was the major causative agent in most of the cholera cases. The recent studies demonstrated the prevalence ofV. choleraeO1, El Tor variants carryingctxB1,ctxB7and Haitian varianttcpAallele associated with polymyxin B sensitivity and these variants are replacing the proto type El Tor. The first report of variantctxB7in Odi...
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Background: Personnel involved in essential services or residing in high risk areas during the CO... more Background: Personnel involved in essential services or residing in high risk areas during the COVID-19 pandemic are at increased risk of getting infected, and higher infection rates among such personnel can paralyze these services due to shortage of staff. Evaluating the proportion of personnel infected can be done using seroprevalence studies or serosurveys.Methods: During July to November, 2020, individuals from multiple high risk groups in 6 urban centres in the state of Odisha, India, which included health care workers, police personnel, municipality/ sanitation staff, residents of urban slums, vendors, press staff, and prisoners, were recruited into the study after obtaining written informed consent. Blood samples collected from the study participants were tested for IgG antibodies against COVID-19 in Roche Cobas e441. Information on socio-demographic variables, association with a confirmed or suspected case, symptoms profile of individuals within 30 days, travel and history o...
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VirusDisease, 2021
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PLOS ONE, 2020
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Journal of Tropical Pediatrics, 2020
Universal Newborn Hearing Screening (UNHS) is a significant public health initiative as early dia... more Universal Newborn Hearing Screening (UNHS) is a significant public health initiative as early diagnosis and intervention are critical for children’s cognitive development. In India, priority for UNHS has been provided since 2013; however, there are various operational challenges associated with it. There is a lack of multi-stakeholders perspective on UNHS, which is crucial for improving the service intake. Therefore, this study attempted to understand the perspective of various stakeholders to explore the practices, processes and technologies used in the existing UNHS landscape in Odisha, India. The qualitative in-depth interviews were conducted among various stakeholders including 15 mothers, 5 service providers (audiologists), 10 districts and state-level programme managers. Data were analysed using content analysis approaches. Two major themes emerged were ‘social-shaping of technology for UNHS’ and ‘mothers’ understanding and experience on UNHS’. Employee retention, equipment li...
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International Journal of Environmental Research and Public Health, 2020
The prevalence and outbreaks of anthrax are interlinked with the animal-environment-human context... more The prevalence and outbreaks of anthrax are interlinked with the animal-environment-human context, which signifies the need for collaborative, trans-disciplinary and multi-sectoral approaches for the prevention and control of anthrax. In India, there are hardly any shreds of evidence on the role of various stakeholders’ on anthrax prevention and control. Therefore, this study addressed the experiences of various stakeholders on anthrax prevention and control strategies in Odisha, India. A qualitative explorative study was carried out using 42 in-depth-interviews among the stakeholders from health, veterinary and general administrative departments from the block, district, and state level. Two major themes emerged: (1) Epidemiological investigation of anthrax in Odisha, India, and (2) Biological and social prevention strategies for anthrax in Odisha, India. The study emphasizes setting up the surveillance system as per standard guideline, and strengthening the diagnostic facility at ...
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Frontiers in Medicine, 2020
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International Journal of Environmental Research and Public Health, 2019
Background: Extreme heat and heat illness are becoming very frequent in India. We aimed to identi... more Background: Extreme heat and heat illness are becoming very frequent in India. We aimed to identify the factors associated with heat illness and the coping practices among city dwellers of Odisha, India during the summer. Methods: A cross-sectional study included 766 households (HHs) in twin cities of Odisha covering a population of 1099 (slum: 404 and non-slum: 695) in the year 2017. We collected information on sociodemographic, household characteristics, coping practices to heat and the heat illness history reported during the summer. Multivariate logistic regression accounting for clustering effects at the household and slum levels was used to identify the associated factors of heat illness after adjustment of other variables. Result: Nearly, 49% of the study participants were female and the mean age was 38.36 years (95% confidence interval (CI): 37.33–39.39 years). A significant difference of living environment was seen across the groups. More than two-thirds of the study partic...
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Papers by Sanghamitra Pati