Reaction: Terbinafine to 1 product
- Reaction
- Reaction type
- hydoxylation
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- inactive
- References
- Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. [Article]
- Vickers AE, Sinclair JR, Zollinger M, Heitz F, Glanzel U, Johanson L, Fischer V: Multiple cytochrome P-450s involved in the metabolism of terbinafine suggest a limited potential for drug-drug interactions. Drug Metab Dispos. 1999 Sep;27(9):1029-38. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Cytochrome P450 1A2 Not Available Not Available confirmed Cytochrome P450 2B6 Not Available Not Available confirmed Cytochrome P450 2C8 Not Available Not Available confirmed Cytochrome P450 2C9 Not Available Not Available confirmed Cytochrome P450 2C19 Not Available Not Available confirmed