Beta-2 adrenergic receptor
Details
- Name
- Beta-2 adrenergic receptor
- Synonyms
- ADRB2R
- B2AR
- Beta-2 adrenoceptor
- Beta-2 adrenoreceptor
- Gene Name
- ADRB2
- UniProtKB Entry
- P07550Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0037061|Beta-2 adrenergic receptor MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
- Number of residues
- 413
- Molecular Weight
- 46458.32
- Theoretical pI
- 7.44
- GO Classification
- Functionsbeta2-adrenergic receptor activity / norepinephrine binding / potassium channel regulator activity / protein homodimerization activityProcessesactivation of transmembrane receptor protein tyrosine kinase activity / adenylate cyclase-activating adrenergic receptor signaling pathway / bone resorption / brown fat cell differentiation / cell surface receptor signaling pathway / diet induced thermogenesis / endosome to lysosome transport / heat generation / negative regulation of multicellular organism growth / negative regulation of smooth muscle contraction / positive regulation of autophagosome maturation / positive regulation of bone mineralization / positive regulation of lipophagy / positive regulation of MAPK cascade / receptor-mediated endocytosis / response to coldComponentsapical plasma membrane / early endosome / endosome / lysosome / nucleus / plasma membrane / receptor complex
- General Function
- Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine
- Specific Function
- adenylate cyclase binding
- Pfam Domain Function
- 7tm_1 (PF00001)
- Signal Regions
- Not Available
- Transmembrane Regions
- 35-58 72-95 107-129 151-174 197-220 275-298 306-329
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0020478|Beta-2 adrenergic receptor (ADRB2) ATGGGGCAACCCGGGAACGGCAGCGCCTTCTTGCTGGCACCCAATAGAAGCCATGCGCCG GACCACGACGTCACGCAGCAAAGGGACGAGGTGTGGGTGGTGGGCATGGGCATCGTCATG TCTCTCATCGTCCTGGCCATCGTGTTTGGCAATGTGCTGGTCATCACAGCCATTGCCAAG TTCGAGCGTCTGCAGACGGTCACCAACTACTTCATCACTTCACTGGCCTGTGCTGATCTG GTCATGGGCCTGGCAGTGGTGCCCTTTGGGGCCGCCCATATTCTTATGAAAATGTGGACT TTTGGCAACTTCTGGTGCGAGTTTTGGACTTCCATTGATGTGCTGTGCGTCACGGCCAGC ATTGAGACCCTGTGCGTGATCGCAGTGGATCGCTACTTTGCCATTACTTCACCTTTCAAG TACCAGAGCCTGCTGACCAAGAATAAGGCCCGGGTGATCATTCTGATGGTGTGGATTGTG TCAGGCCTTACCTCCTTCTTGCCCATTCAGATGCACTGGTACCGGGCCACCCACCAGGAA GCCATCAACTGCTATGCCAATGAGACCTGCTGTGACTTCTTCACGAACCAAGCCTATGCC ATTGCCTCTTCCATCGTGTCCTTCTACGTTCCCCTGGTGATCATGGTCTTCGTCTACTCC AGGGTCTTTCAGGAGGCCAAAAGGCAGCTCCAGAAGATTGACAAATCTGAGGGCCGCTTC CATGTCCAGAACCTTAGCCAGGTGGAGCAGGATGGGCGGACGGGGCATGGACTCCGCAGA TCTTCCAAGTTCTGCTTGAAGGAGCACAAAGCCCTCAAGACGTTAGGCATCATCATGGGC ACTTTCACCCTCTGCTGGCTGCCCTTCTTCATCGTTAACATTGTGCATGTGATCCAGGAT AACCTCATCCGTAAGGAAGTTTACATCCTCCTAAATTGGATAGGCTATGTCAATTCTGGT TTCAATCCCCTTATCTACTGCCGGAGCCCAGATTTCAGGATTGCCTTCCAGGAGCTTCTG TGCCTGCGCAGGTCTTCTTTGAAGGCCTATGGGAATGGCTACTCCAGCAACGGCAACACA GGGGAGCAGAGTGGATATCACGTGGAACAGGAGAAAGAAAATAAACTGCTGTGTGAAGAC CTCCCAGGCACGGAAGACTTTGTGGGCCATCAAGGTACTGTGCCTAGCGATAACATTGAT TCACAAGGGAGGAATTGTAGTACAAATGACTCACTGCTGTAA
- Chromosome Location
- 5
- Locus
- 5q32
- External Identifiers
Resource Link UniProtKB ID P07550 UniProtKB Entry Name ADRB2_HUMAN GenBank Protein ID 29371 GenBank Gene ID Y00106 GeneCard ID ADRB2 GenAtlas ID ADRB2 HGNC ID HGNC:286 PDB ID(s) 1GQ4, 2R4R, 2R4S, 2RH1, 3D4S, 3KJ6, 3NY8, 3NY9, 3NYA, 3P0G, 3PDS, 3SN6, 4GBR, 4LDE, 4LDL, 4LDO, 4QKX, 5D5A, 5D5B, 5D6L, 5JQH, 5X7D, 6E67, 6KR8, 6MXT, 6N48, 6NI3, 6OBA, 6PRZ, 6PS0, 6PS1, 6PS2, 6PS3, 6PS4, 6PS5, 6PS6, 7BZ2, 7DHI, 7DHR, 7XK9, 7XKA, 8GDZ, 8GE1, 8GE2, 8GE3, 8GE4, 8GE5, 8GE6, 8GE7, 8GE8, 8GE9, 8GEA, 8GEB, 8GEC, 8GED, 8GEE, 8GEF, 8GEG, 8GEH, 8GEI, 8GEJ, 8GFV, 8GFW, 8GFX, 8GFY, 8GFZ, 8GG0, 8GG1, 8GG2, 8GG3, 8GG4, 8GG5, 8GG6, 8GG7, 8GG8, 8GG9, 8GGA, 8GGB, 8GGC, 8GGE, 8GGF, 8GGI, 8GGJ, 8GGK, 8GGL, 8GGM, 8GGN, 8GGO, 8GGP, 8GGQ, 8GGR, 8GGS, 8GGT, 8GGU, 8GGV, 8GGW, 8GGX, 8GGY, 8GGZ, 8GH0, 8GH1, 8JJ8, 8JJL, 8JJO, 8UHB, 8UNL, 8UNM, 8UNN, 8UNO, 8UNP, 8UNQ, 8UNR, 8UNS, 8UNT, 8UNU, 8UNV, 8UNW, 8UNX, 8UNY, 8UNZ, 8UO0, 8UO1, 8UO2, 8UO3, 8UO4 KEGG ID hsa:154 IUPHAR/Guide To Pharmacology ID 29 NCBI Gene ID 154 - General References
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- Chung FZ, Wang CD, Potter PC, Venter JC, Fraser CM: Site-directed mutagenesis and continuous expression of human beta-adrenergic receptors. Identification of a conserved aspartate residue involved in agonist binding and receptor activation. J Biol Chem. 1988 Mar 25;263(9):4052-5. [Article]
- O'Dowd BF, Hnatowich M, Caron MG, Lefkowitz RJ, Bouvier M: Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor. J Biol Chem. 1989 May 5;264(13):7564-9. [Article]
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Associated Data
- Bio-Entities
Bio-Entity Type Beta-2 adrenergic receptor (Humans) protein primaryBeta adrenergic receptor (Humans) protein - Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Carteolol approved yes target antagonist Details Orciprenaline approved yes target agonist Details Ritodrine approved, investigational yes target agonist Details Terbutaline approved yes target agonist Details Bitolterol withdrawn yes target Details Salmeterol approved yes target agonist Details Formoterol approved, investigational yes target agonist Details Albuterol approved, vet_approved yes target agonist Details Timolol approved yes target antagonist Details Propranolol approved, investigational unknown target antagonist Details Labetalol approved yes target antagonist Details Bisoprolol approved no target antagonist Details Epinephrine approved, vet_approved yes target agonist Details Pseudoephedrine approved unknown target partial agonist Details Alprenolol experimental, withdrawn yes target antagonist Details Pindolol approved, investigational yes target partial agonist Details Isoprenaline approved, investigational yes target agonistbinder Details Desipramine approved, investigational unknown target antagonist Details Nadolol approved unknown target antagonist Details Levobunolol approved yes target antagonist Details Metipranolol approved yes target antagonist Details Arformoterol approved, investigational yes target agonist Details Procaterol approved, investigational yes target agonist Details Clenbuterol approved, investigational, vet_approved yes target agonist Details Carvedilol approved, investigational unknown target antagonist Details Fenoterol approved, investigational yes target agonist Details Pirbuterol approved yes target agonist Details Oxprenolol approved unknown target antagonist Details Penbutolol approved, investigational yes target antagonistpartial agonist Details Norepinephrine approved yes target agonist Details Bambuterol investigational yes target agonist Details Indacaterol approved yes target agonist Details NCX 950 investigational unknown target Details Droxidopa approved, investigational yes target agonist Details PW2101 investigational unknown target Details Metoprolol approved, investigational no target antagonist Details Betaxolol approved, investigational unknown target antagonist Details Sotalol approved yes target antagonist Details Bevantolol experimental unknown target antagonist Details Acebutolol approved, investigational unknown target partial agonist Details Arbutamine approved unknown target agonist Details Dobutamine approved unknown target agonist Details (S)-carazolol experimental unknown target Details Dipivefrin approved yes target agonist Details Bopindolol experimental yes target antagonistpartial agonist Details Bupranolol experimental unknown target antagonist Details Nebivolol approved, investigational unknown target antagonist Details Phenoxybenzamine approved unknown target Details Ephedra sinica root nutraceutical yes target agonist Details Asenapine approved unknown target antagonist Details Cabergoline approved unknown target binder Details Isoetharine approved unknown target agonist Details Atenolol approved unknown target antagonist Details Phenylpropanolamine approved, vet_approved, withdrawn unknown target agonist Details Olodaterol approved yes target agonist Details Vilanterol approved yes target agonist Details Celiprolol approved, investigational yes target agonist Details Levosalbutamol approved, investigational yes target agonist Details Befunolol experimental unknown target Details Tulobuterol investigational unknown target regulator Details Putrescine experimental unknown target Details Spermidine experimental unknown target Details Spermine experimental, nutraceutical unknown target Details Propafenone approved unknown target antagonist Details Arotinolol investigational yes target antagonist Details Doxofylline experimental yes target agonist Details Protokylol approved, vet_approved yes target agonist Details Racepinephrine approved yes target agonist Details Etafedrine approved yes target agonist Details Bedoradrine investigational yes target agonist Details Aripiprazole approved, investigational unknown target ligand Details Ephedrine approved yes target agonist Details Viloxazine approved, investigational, withdrawn unknown target antagonist Details Methoxyphenamine approved unknown target regulator Details Iloperidone approved unknown target antagonist Details Dichloroisoproterenol investigational yes target inhibitor Details PF-00610355 investigational yes target agonist Details Carmoterol experimental yes target agonist Details APD-209 investigational yes target agonist Details Abediterol investigational yes target agonist Details Batefenterol investigational yes target modulator Details Bucindolol investigational yes target modulator Details Amiodarone approved, investigational yes target inhibitordownregulator Details Amphetamine approved, illicit, investigational unknown target agonist Details Nortriptyline approved unknown target antagonist Details Trimipramine approved unknown target binder Details Olanzapine approved, investigational no target inhibitor Details Bethanidine approved unknown target antagonist Details Mephentermine approved unknown target agonist Details Bufuralol experimental unknown target antagonist Details Dihydroergocristine approved, experimental yes target antagonistagonist Details Ergoloid mesylate approved yes target antagonistagonist Details Dihydroergocornine approved yes target antagonistagonist Details DL-Methylephedrine approved yes target agonist Details Paroxetine approved, investigational unknown target inhibitor Details Cryptenamine approved unknown target inhibitorpotentiator Details Ritodrine approved, investigational yes target agonistdownregulator Details Metoprolol approved, investigational unknown target inhibitor Details