Explore a selection of our essential drug information below, or:
Identification
- Summary
Antihemophilic factor, human recombinant is a form of recombinant coagulation Factor VIII used to treat hemophilia A, von Willebrand disease, and Factor XIII deficiency.
- Brand Names
- Advate, Adynovate, Helixate, Kogenate, Kovaltry, Novoeight, Recombinate
- Generic Name
- Antihemophilic factor, human recombinant
- DrugBank Accession Number
- DB00025
- Background
Human recombinant antihemophilic factor (AHF) or Factor VIII, 2332 residues, glycosylated, produced by CHO cells
- Type
- Biotech
- Groups
- Approved, Investigational
- Biologic Classification
- Protein Based Therapies
Blood factors - Protein Structure
- Protein Chemical Formula
- C11794H18314N3220O3553S83
- Protein Average Weight
- 264725.5 Da
- Sequences
>DB00025 sequence ATRRYYLGAVELSWDYMQSDLGELPVDARFPPRVPKSFPFNTSVVYKKTLFVEFTDHLFN IAKPRPPWMGLLGPTIQAEVYDTVVITLKNMASHPVSLHAVGVSYWKASEGAEYDDQTSQ REKEDDKVFPGGSHTYVWQVLKENGPMASDPLCLTYSYLSHVDLVKDLNSGLIGALLVCR EGSLAKEKTQTLHKFILLFAVFDEGKSWHSETKNSLMQDRDAASARAWPKMHTVNGYVNR SLPGLIGCHRKSVYWHVIGMGTTPEVHSIFLEGHTFLVRNHRQASLEISPITFLTAQTLL MDLGQFLLFCHISSHQHDGMEAYVKVDSCPEEPQLRMKNNEEAEDYDDDLTDSEMDVVRF DDDNSPSFIQIRSVAKKHPKTWVHYIAAEEEDWDYAPLVLAPDDRSYKSQYLNNGPQRIG RKYKKVRFMAYTDETFKTREAIQHESGILGPLLYGEVGDTLLIIFKNQASRPYNIYPHGI TDVRPLYSRRLPKGVKHLKDFPILPGEIFKYKWTVTVEDGPTKSDPRCLTRYYSSFVNME RDLASGLIGPLLICYKESVDQRGNQIMSDKRNVILFSVFDENRSWYLTENIQRFLPNPAG VQLEDPEFQASNIMHSINGYVFDSLQLSVCLHEVAYWYILSIGAQTDFLSVFFSGYTFKH KMVYEDTLTLFPFSGETVFMSMENPGLWILGCHNSDFRNRGMTALLKVSSCDKNTGDYYE DSYEDISAYLLSKNNAIEPRSFSQNSRHPSTRQKQFNATTIPENDIEKTDPWFAHRTPMP KIQNVSSSDLLMLLRQSPTPHGLSLSDLQEAKYETFSDDPSPGAIDSNNSLSEMTHFRPQ LHHSGDMVFTPESGLQLRLNEKLGTTAATELKKLDFKVSSTSNNLISTIPSDNLAAGTDN TSSLGPPSMPVHYDSQLDTTLFGKKSSPLTESGGPLSLSEENNDSKLLESGLMNSQESSW GKNVSSTESGRLFKGKRAHGPALLTKDNALFKVSISLLKTNKTSNNSATNRKTHIDGPSL LIENSPSVWQNILESDTEFKKVTPLIHDRMLMDKNATALRLNHMSNKTTSSKNMEMVQQK KEGPIPPDAQNPDMSFFKMLFLPESARWIQRTHGKNSLNSGQGPSPKQLVSLGPEKSVEG QNFLSEKNKVVVGKGEFTKDVGLKEMVFPSSRNLFLTNLDNLHENNTHNQEKKIQEEIEK KETLIQENVVLPQIHTVTGTKNFMKNLFLLSTRQNVEGSYDGAYAPVLQDFRSLNDSTNR TKKHTAHFSKKGEEENLEGLGNQTKQIVEKYACTTRISPNTSQQNFVTQRSKRALKQFRL PLEETELEKRIIVDDTSTQWSKNMKHLTPSTLTQIDYNEKEKGAITQSPLSDCLTRSHSI PQANRSPLPIAKVSSFPSIRPIYLTRVLFQDNSSHLPAASYRKKDSGVQESSHFLQGAKK NNLSLAILTLEMTGDQREVGSLGTSATNSVTYKKVENTVLPKPDLPKTSGKVELLPKVHI YQKDLFPTETSNGSPGHLDLVEGSLLQGTEGAIKWNEANRPGKVPFLRVATESSAKTPSK LLDPLAWDNHYGTQIPKEEWKSQEKSPEKTAFKKKDTILSLNACESNHAIAAINEGQNKP EIEVTWAKQGRTERLCSQNPPVLKRHQREITRTTLQSDQEEIDYDDTISVEMKKEDFDIY DEDENQSPRSFQKKTRHYFIAAVERLWDYGMSSSPHVLRNRAQSGSVPQFKKVVFQEFTD GSFTQPLYRGELNEHLGLLGPYIRAEVEDNIMVTFRNQASRPYSFYSSLISYEEDQRQGA EPRKNFVKPNETKTYFWKVQHHMAPTKDEFDCKAWAYFSDVDLEKDVHSGLIGPLLVCHT NTLNPAHGRQVTVQEFALFFTIFDETKSWYFTENMERNCRAPCNIQMEDPTFKENYRFHA INGYIMDTLPGLVMAQDQRIRWYLLSMGSNENIHSIHFSGHVFTVRKKEEYKMALYNLYP GVFETVEMLPSKAGIWRVECLIGEHLHAGMSTLFLVYSNKCQTPLGMASGHIRDFQITAS GQYGQWAPKLARLHYSGSINAWSTKEPFSWIKVDLLAPMIIHGIKTQGARQKFSSLYISQ FIIMYSLDGKKWQTYRGNSTGTLMVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRS TLRMELMGCDLNSCSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWR PQVNNPKEWLQVDFQKTMKVTGVTTQGVKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKV KVFQGNQDSFTPVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCEAQDLY
Download FASTA Format- Synonyms
- Antihemophilic factor (recombinant)
- Antihemophilic factor recombinant
- Antihemophilic factor, human recombinant
- Antihemophilic factor, recombinant
- Coagulation factor VIII, recombinant
- Factor VIII (rDNA)
- Factor VIII (Recombinant)
- Factor VIII recombin
- Factor VIII, recombinant
- Human Factor VIII (Recombinant)
- Human factor VIII recombinant
- Octocog alfa
- rAHF
- Recombinant antihemophilic factor VIII
- External IDs
- BAY 14-2222
- BAY 81-8973
- BAY W 6240
- BAY-14-2222
- BAY-81-8973
- BAY-W-6240
- BAY81-8973
Pharmacology
- Indication
The human recombinant antihemophilic factor is indicated for use in adults and children with hemophilia A for the control and prevention of bleeding episodes, perioperative management, and routine prophylaxis to prevent or reduce the frequency of bleeding episodes.2,3
Reduce drug development failure ratesBuild, train, & validate machine-learning modelswith evidence-based and structured datasets.Build, train, & validate predictive machine-learning models with structured datasets.- Associated Conditions
Indication Type Indication Combined Product Details Approval Level Age Group Patient Characteristics Dose Form Management of Bleeding •••••••••••• ••••••••••• •••••• ••••••• ••••••••• ••••••••• Prophylaxis of Bleeding •••••••••••• ••••••••••• •••••• ••••••• ••••••••• ••••••••• Prevention of Bleeding •••••••••••• ••••••••••• •••••• ••••••• ••••••••• ••••••••• Prevention of Joint damage •••••••••••• ••••••••• •••••••••• •• Management of Perioperative bleeding •••••••••••• ••••••••••• •••••• ••••••• ••••••••• ••••••••• - Contraindications & Blackbox Warnings
Prevent Adverse Drug Events TodayTap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.Avoid life-threatening adverse drug events with our Clinical API- Pharmacodynamics
Antihemophilic Factor binds factor IXa along with calcium and phospholipid, This complex converts factor X to factor Xa to facilitate clotting cascade.
- Mechanism of action
Antihemophilic factor (AHF) is a protein found in normal plasma which is necessary for clot formation. The administration of AHF provides an increase in plasma levels of AHF and can temporarily correct the coagulation defect of patients with hemophilia A (classical hemophilia).
Target Actions Organism ACoagulation factor X activatorHumans ACoagulation factor IX cofactorHumans Avon Willebrand factor binderHumans UPhytanoyl-CoA dioxygenase, peroxisomal antagonistHumans UAsialoglycoprotein receptor 2 binderHumans UEndoplasmic reticulum chaperone BiP chaperoneHumans UCalreticulin chaperoneHumans UCalnexin chaperoneHumans UProtein ERGIC-53 chaperoneHumans UProlow-density lipoprotein receptor-related protein 1 modulatorHumans UMultiple coagulation factor deficiency protein 2 modulatorHumans - Absorption
Not Available
- Volume of distribution
Not Available
- Protein binding
Not Available
- Metabolism
- Not Available
- Route of elimination
Not Available
- Half-life
8.4-19.3 hrs
- Clearance
- 4.1 mL/h•kg [Previously treated pediatric patients]
- Adverse Effects
Improve decision support & research outcomesWith structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!Improve decision support & research outcomes with our structured adverse effects data.- Toxicity
Not Available
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Integrate drug-drug
interactions in your softwareAbciximab The therapeutic efficacy of Antihemophilic factor, human recombinant can be decreased when used in combination with Abciximab. Acenocoumarol The therapeutic efficacy of Antihemophilic factor, human recombinant can be decreased when used in combination with Acenocoumarol. Alpha-1-proteinase inhibitor Alpha-1-proteinase inhibitor may increase the thrombogenic activities of Antihemophilic factor, human recombinant. Alteplase The therapeutic efficacy of Antihemophilic factor, human recombinant can be decreased when used in combination with Alteplase. Aminocaproic acid The risk or severity of adverse effects can be increased when Aminocaproic acid is combined with Antihemophilic factor, human recombinant. - Food Interactions
- No interactions found.
Products
Drug product information from 10+ global regionsOur datasets provide approved product information including:dosage, form, labeller, route of administration, and marketing period.Access drug product information from over 10 global regions.- International/Other Brands
- Bioclate / Helixate / Hyate:C / Koate-HP / Kogenate / Monarc-M / ReFacto
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Advate Powder, for solution 1000 unit / vial Intravenous Takeda Italia S.P.A. Not applicable Not applicable Canada 
Advate Injection, powder, for solution 500 IU Intravenous Takeda Manufacturing Austria Ag 2016-09-07 Not applicable EU 
Advate Injection, powder, for solution 1000 IU Intravenous Takeda Manufacturing Austria Ag 2016-09-07 Not applicable EU Advate Injection, powder, lyophilized, for solution; Kit 750 [iU]/1mL Intravenous Takeda Pharma A/S 2011-12-15 Not applicable US 
Advate Kit 250 [iU]/1mL Intravenous Baxalta US Inc. 2012-07-12 2016-08-26 US - Mixture Products
Name Ingredients Dosage Route Labeller Marketing Start Marketing End Region Image ALPHANATE Antihemophilic factor, human recombinant (500 IU) + Von Willebrand factor human (600 IU) Injection, powder, lyophilized, for solution Parenteral GRIFOLS USA, LLC 2014-07-08 Not applicable Italy 
FANHDI Antihemophilic factor, human recombinant (500 IU/10mL) + Von Willebrand factor human (600 IU/10mL) Injection, powder, lyophilized, for solution Intravenous Instituto Grifols, S.A. 2014-07-08 Not applicable Italy FANHDI Antihemophilic factor, human recombinant (1000 IU/10mL) + Von Willebrand factor human (1200 IU/10mL) Injection, powder, lyophilized, for solution Intravenous Instituto Grifols, S.A. 2014-07-08 Not applicable Italy FANHDI Antihemophilic factor, human recombinant (250 IU/10mL) + Von Willebrand factor human (300 IU/10mL) Injection, powder, lyophilized, for solution Intravenous Instituto Grifols, S.A. 2014-07-08 Not applicable Italy FANHDI Antihemophilic factor, human recombinant (1500 IU/15mL) + Von Willebrand factor human (1800 IU/15mL) Injection, powder, lyophilized, for solution Intravenous Instituto Grifols, S.A. 2014-07-08 Not applicable Italy
Categories
- ATC Codes
- B02BD02 — Coagulation factor viii
- Drug Categories
- Amino Acids, Peptides, and Proteins
- Biological Factors
- Blood and Blood Forming Organs
- Blood Coagulation Factors
- Blood Proteins
- Carbohydrates
- Disaccharides
- Hemophilia A
- Hemostatics
- Human Antihemophilic Factors
- Increased Coagulation Activity
- Oligosaccharides
- Polysaccharides
- Protein Precursors
- Proteins
- Chemical TaxonomyProvided by Classyfire
- Description
- Not Available
- Kingdom
- Organic Compounds
- Super Class
- Organic Acids
- Class
- Carboxylic Acids and Derivatives
- Sub Class
- Amino Acids, Peptides, and Analogues
- Direct Parent
- Peptides
- Alternative Parents
- Not Available
- Substituents
- Not Available
- Molecular Framework
- Not Available
- External Descriptors
- Not Available
- Affected organisms
- Humans and other mammals
Chemical Identifiers
- UNII
- P89DR4NY54
- CAS number
- 139076-62-3
References
- Synthesis Reference
James W. Bloom, "Warm ethanol method for preparation of low fibrinogen antihemophilic factor." U.S. Patent US4478825, issued June, 1955.
US4478825- General References
- Titheradge MA, Coore HG: Initial rates of pyruvate transport in mitochondria determined by an "inhibitor-stop" technique. Biochem J. 1975 Sep;150(3):553-6. [Article]
- FDA Approved Drug Products: KOGENATE FS (Antihemophilic Factor [Recombinant], Formulated with Sucrose) For Intravenous Use, Lyophilized Powder for Reconstitution [Link]
- DailyMed Label: ADVATE [antihemophilic factor (recombinant)] lyophilized powder for reconstitution, for intravenous injection [Link]
- External Links
- UniProt
- P00451
- Genbank
- M14113
- PubChem Substance
- 46506209
- 1300486
- ChEMBL
- CHEMBL2108175
- PharmGKB
- PA164750168
- RxList
- RxList Drug Page
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Antihemophilic_Factor
Clinical Trials
- Clinical Trials
Clinical Trial & Rare Diseases Add-on Data Package
Explore 4,000+ rare diseases, orphan drugs & condition pairs, clinical trial why stopped data, & more. Preview package Phase Status Purpose Conditions Count Start Date Why Stopped 100+ additional columns Unlock 175K+ rows when you subscribe.View sample dataNot Available Active Not Recruiting Not Available Hemophilia A 1 somestatus stop reason just information to hide Not Available Completed Not Available Coagulation Disorder / Hemophilia A 1 somestatus stop reason just information to hide Not Available Completed Not Available Congenital Factor VIII (FVIII) Deficiency / Hemophilia A 1 somestatus stop reason just information to hide Not Available Completed Not Available Coronavirus Disease 2019 (COVID‑19) / Hemophilia A 1 somestatus stop reason just information to hide Not Available Completed Not Available Factor VIII Deficiency / Hemophilia / Hemophilia A 1 somestatus stop reason just information to hide
Pharmacoeconomics
- Manufacturers
- Not Available
- Packagers
- Baxter International Inc.
- Bayer Healthcare
- CSL Behring LLC
- GlaxoSmithKline Inc.
- Grifols SA
- Ipsen Pharmaceuticals Inc.
- Octapharma USA
- Talecris Biotherapeutics
- Wyeth Pharmaceuticals
- Dosage Forms
Form Route Strength Injection, powder, for solution Intravenous 1500 IU Injection, powder, for solution Intravenous; Parenteral 100 UI Injection, powder, for solution Intravenous; Parenteral 1500 UI Injection, powder, lyophilized, for solution; kit Intravenous 125 [iU]/1mL Injection, powder, lyophilized, for solution; kit Intravenous 250 [iU]/1mL Injection, powder, lyophilized, for solution; kit Intravenous 400 [iU]/1mL Injection, powder, lyophilized, for solution; kit Intravenous 500 [iU]/1mL Injection, powder, lyophilized, for solution; kit Intravenous 600 [iU]/1mL Injection, powder, lyophilized, for solution; kit Intravenous 750 [iU]/1mL Injection, powder, lyophilized, for solution; kit Intravenous 800 [iU]/1mL Kit Intravenous 100 [iU]/1mL Kit Intravenous 125 [iU]/1mL Kit Intravenous 200 [iU]/1mL Kit Intravenous 250 [iU]/1mL Kit Intravenous 300 [iU]/1mL Kit Intravenous 400 [iU]/1mL Kit Intravenous 50 [iU]/1mL Kit Intravenous 500 [iU]/1mL Kit Intravenous 600 [iU]/1mL Kit Intravenous 750 [iU]/1mL Kit Intravenous 800 [iU]/1mL Powder, for solution Intravenous 1500 unit / vial Powder, for solution Intravenous 3000 unit / vial Solution Intravenous 500.000 UI Injection, powder, lyophilized, for solution Intravenous 1000 iu/5ml Injection, powder, lyophilized, for solution Intravenous 1500 IU Injection, powder, lyophilized, for solution Intravenous 1500 iu/5ml Injection, powder, lyophilized, for solution Intravenous 2000 iu/5ml Injection, powder, lyophilized, for solution Intravenous 2000 IU Injection, powder, lyophilized, for solution Intravenous 250 iu/5ml Injection, powder, lyophilized, for solution Intravenous Injection, powder, lyophilized, for solution Intravenous 500 iu/5ml Injection, powder, lyophilized, for solution; kit Intravenous 1000 [iU]/2mL Injection, powder, lyophilized, for solution; kit Intravenous 1500 [iU]/2mL Injection, powder, lyophilized, for solution; kit Intravenous 250 [iU]/2mL Injection, powder, lyophilized, for solution; kit Intravenous 500 [iU]/2mL Injection, powder, lyophilized, for solution; kit Intravenous 750 [iU]/5mL Injection, powder, lyophilized, for solution; kit Intravenous 750 [iU]/2mL Injection, powder, for solution Intravenous; Parenteral 2500 UI Injection, powder, lyophilized, for solution Parenteral Powder Parenteral 1000 IU/10ml Powder Parenteral 2000 IU/10ml Powder Parenteral 250 IU/2.5ML Powder Parenteral 500 IU/5ML Injection, powder, lyophilized, for solution Intravenous 100 IU Injection, powder, for solution Intravenous; Parenteral 4000 UI Injection, powder, for solution Intravenous; Parenteral 5000 UI Injection, powder, for solution Intravenous; Parenteral 6000 UI Injection, powder, for solution Intravenous; Parenteral 750 UI Injection, powder, for solution Intravenous 1000 IU/30mL Injection, powder, lyophilized, for solution Intravenous 100 IU/10ml Injection, powder, lyophilized, for solution Intravenous 1000 IU/10ml Injection, powder, lyophilized, for solution Intravenous 250 IU/10ml Injection, powder, lyophilized, for solution Intravenous 3000 IU/10ml Injection, powder, lyophilized, for solution Intravenous 500 IU/10ml Injection, solution Intravenous 100 IU Injection, solution Intravenous 250 IU Injection, solution Intravenous 500 IU Powder, for solution Parenteral 1000 U.I. Powder, for solution Parenteral 250 U.I. Powder, for solution Parenteral 500 U.I. Injection, powder, for solution Parenteral 5000 IU Injection, powder, for solution Intravenous 100 IU Injection, powder, for solution Intravenous 20 IU/mL Injection, powder, for solution Intravenous 250 IU Injection, solution Intravenous 100 IU/5ML Injection, solution Intravenous 1000 IU/10ML Injection, solution Intravenous 250 IU/10ML Injection, solution Intravenous 500 IU/10ML Injection, solution Intravenous 500 IU/20ML Powder, for solution Parenteral 250 UI Powder, for solution Parenteral 500 UI/10ML Powder, for solution Intravenous; Parenteral 1000 UI Powder, for solution Intravenous; Parenteral 250 UI Powder, for solution Intravenous; Parenteral 500 UI Injection, powder, lyophilized, for solution Intravenous 1000 IU Powder, for solution Parenteral Injection, powder, for solution Intravenous 3000 IU Injection, powder, for solution Intravenous; Parenteral 1000 UI Injection, powder, for solution Intravenous; Parenteral 250 UI Injection, powder, for solution Intravenous; Parenteral 500 UI Powder Intravenous 2000 UI Injection, powder, for solution Intravenous 3000 UI Injection, powder, for solution Solution Intravenous 500 UI Injection, powder, for solution Intravenous 1000 UI Injection, powder, for solution Intravenous 1000 IU Injection, powder, for solution Intravenous 2000 IU Injection, powder, for solution Intravenous 2000 UI Injection, powder, for solution Intravenous 250 UI Injection, powder, for solution Intravenous 500 UI Injection, powder, for solution Intravenous 500 IU Powder Intravenous 3000 UI Kit Intravenous 1000 [iU]/2.5mL Kit Intravenous 2000 [iU]/5mL Kit Intravenous 250 [iU]/2.5mL Kit Intravenous 3000 [iU]/5mL Kit Intravenous 500 [iU]/2.5mL Powder, for solution Intravenous 2000 unit / vial Injection, powder, lyophilized, for solution Intravenous 1000 IU/vial Injection, powder, lyophilized, for solution Intravenous 250 IU/vial Injection, powder, lyophilized, for solution Intravenous 500 IU/vial Injection, powder, for solution Intravenous; Parenteral 2000 UI Injection, powder, for solution Intravenous; Parenteral 3000 UI Injection, powder, lyophilized, for solution; kit Intravenous 1000 [iU]/2.5mL Injection, powder, lyophilized, for solution; kit Intravenous 250 [iU]/2.5mL Injection, powder, lyophilized, for solution; kit Intravenous 3000 [iU]/5mL Injection, powder, lyophilized, for solution; kit Intravenous 500 [iU]/2.5mL Kit; powder, for solution Intravenous 1000 unit / vial Kit; powder, for solution Intravenous 2000 unit / vial Kit; powder, for solution Intravenous 250 unit / vial Kit; powder, for solution Intravenous 3000 unit / vial Kit; powder, for solution Intravenous 500 unit / vial Solution Intravenous 2000 UI Injection, powder, lyophilized, for solution Intravenous 250 IU Powder Intravenous 1000 IU Powder Intravenous 1500 IU Powder Intravenous 250 IU Injection, powder, lyophilized, for solution; kit Intravenous 375 [iU]/1mL Injection, powder, lyophilized, for solution; kit Intravenous 62.5 [iU]/1mL Injection, powder, for solution Intravenous; Parenteral 1000 IU Injection, powder, for solution Intravenous; Parenteral 2000 IU Injection, powder, for solution Intravenous; Parenteral 250 IU Injection, powder, for solution Intravenous; Parenteral 500 IU Injection, powder, for solution Parenteral 50 IU/ML Injection, powder, lyophilized, for solution Intravenous Injection, powder, for solution Intravenous 1000 IU/10ML Injection, powder, for solution Intravenous 250 IU/10ML Injection, powder, for solution Intravenous 500 IU/10ML Injection, powder, for solution Parenteral 1000 U.I./10ML Injection, powder, for solution Parenteral 1000 U.I./5ML Injection, powder, for solution Parenteral 250 U.I./5ML Injection, powder, for solution Parenteral 250 U.I./10ML Injection, powder, for solution Parenteral 500 U.I./10ML Injection, powder, for solution Parenteral 500 U.I./5ML Injection, powder, lyophilized, for solution; kit Intravenous 100 [iU]/1mL Injection, powder, lyophilized, for solution; kit Intravenous 1000 [iU]/5mL Injection, powder, lyophilized, for solution; kit Intravenous 1500 [iU]/5mL Injection, powder, lyophilized, for solution; kit Intravenous 2000 [iU]/5mL Injection, powder, lyophilized, for solution; kit Intravenous 25 [iU]/1mL Injection, powder, lyophilized, for solution; kit Intravenous 250 [iU]/5mL Injection, powder, lyophilized, for solution; kit Intravenous 50 [iU]/1mL Injection, powder, lyophilized, for solution; kit Intravenous 500 [iU]/5mL Solution Intravenous Powder, for solution Intravenous 1000 unit / vial Powder, for solution Intravenous 250 unit / vial Powder, for solution Intravenous 500 unit / vial Injection Intravenous 1000 IU/4ml Injection Intravenous 2000 IU/4ml Injection Intravenous 3000 IU/4ml Injection Intravenous 500 IU/4ml Solution Intravenous 250 IU/4ml Injection, powder, for solution Parenteral Injection, powder, for solution Intravenous 2500 UI Injection, powder, for solution Intravenous 4000 UI Powder Intravenous 500 IU Injection, powder, lyophilized, for solution Intravenous 500 IU Injection, solution Intravenous Injection, powder, for solution Intravenous 1000 iu/1vial Injection, powder, for solution Intravenous 250 iu/1vial Injection, powder, for solution Intravenous 500 iu/1vial Injection, powder, for solution 1000 IU Injection, powder, for solution 1500 IU Injection, powder, for solution 250 IU Injection, powder, for solution 500 IU - Prices
Unit description Cost Unit Advate 1201-1800 unit vial 1.68USD vial Advate 1801-2400 unit vial 1.68USD vial Advate 200-400 unit vial 1.68USD vial Advate 2400-3600 unit vial 1.68USD vial Advate 401-800 unit vial 1.68USD vial Advate 801-1200 unit vial 1.68USD vial Kogenate fs 1000 unit vial 1.68USD vial Kogenate fs 250 unit vial 1.68USD vial Kogenate fs 3000 unit vial 1.68USD vial Kogenate fs 500 unit vial 1.68USD vial Xyntha 1000 unit kit 1.66USD kit Xyntha 2000 unit kit 1.66USD kit Xyntha 250 unit kit 1.66USD kit Xyntha 500 unit kit 1.66USD kit Helixate fs 1000 unit vial 1.56USD vial Helixate fs 250 unit vial 1.56USD vial Helixate fs 3000 unit vial 1.56USD vial Helixate fs 500 unit vial 1.56USD vial Wilate 450-450 unit kit 1.38USD kit Wilate 900-900 unit kit 1.38USD kit Hemofil m 1701-2000 unit vial 1.34USD vial Hemofil m 220-400 unit vial 1.34USD vial Hemofil m 401-800 unit vial 1.34USD vial Hemofil m 801-1700 unit vial 1.34USD vial Koate-dvi 1000 unit kit 1.31USD kit Koate-dvi 250 unit kit 1.31USD kit Koate-dvi 500 unit kit 1.31USD kit Refacto 1000 unit vial 1.31USD vial Refacto 2000 unit vial 1.31USD vial Refacto 250 unit vial 1.31USD vial Refacto 500 unit vial 1.31USD vial Alphanate 1000-1500 unit vial 1.2USD vial Alphanate 250-500 unit vial 1.2USD vial Humate-p 1000 unit kit 1.2USD kit Humate-p 1200 unit kit 1.2USD kit Humate-p 2000 unit kit 1.2USD kit Humate-p 2400 unit kit 1.2USD kit Humate-p 500 unit kit 1.2USD kit Humate-p 600 unit kit 1.2USD kit Monoclate-p 1000 unit kit 1.01USD kit Monoclate-p 1500 unit kit 1.01USD kit Monoclate-p 250 unit kit 1.01USD kit Monoclate-p 500ahfu kit 1.01USD kit DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region CA2124690 No 2007-09-11 2013-10-01 Canada CA1339477 No 1997-09-23 2014-09-23 Canada
Properties
- State
- Solid
- Experimental Properties
Property Value Source hydrophobicity -0.533 Not Available isoelectric point 6.97 Not Available
Targets
Build, predict & validate machine-learning models
Use our structured and evidence-based datasets to unlock newinsights and accelerate drug research.
Use our structured and evidence-based datasets to unlock new insights and accelerate drug research.
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Activator
- General Function
- Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. Factor Xa activates pro-inflammatory signaling pathways in a protease-activated receptor (PAR)-dependent manner (PubMed:24041930, PubMed:30568593, PubMed:34831181). Up-regulates expression of protease-activated receptors (PARs) F2R, F2RL1 and F2RL2 in dermal microvascular endothelial cells (PubMed:35738824). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, in cardiac fibroblasts and umbilical vein endothelial cells in PAR-1 (F2R)-dependent manner (PubMed:30568593, PubMed:34831181). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2, IL6, TNF-alpha/TNF, IL-1beta/IL1B, IL8/CXCL8 and IL18, in endothelial cells and atrial tissues (PubMed:24041930, PubMed:35738824, PubMed:9780208). Induces expression of adhesion molecules, such as ICAM1, VCAM1 and SELE, in endothelial cells and atrial tissues (PubMed:24041930, PubMed:35738824, PubMed:9780208). Increases expression of phosphorylated ERK1/2 in dermal microvascular endothelial cells and atrial tissues (PubMed:24041930, PubMed:35738824). Triggers activation of the transcription factor NF-kappa-B in dermal microvascular endothelial cells and atrial tissues (PubMed:24041930, PubMed:35738824). Up-regulates expression of plasminogen activator inhibitor 1 (SERPINE1) in atrial tissues (PubMed:24041930)
- Specific Function
- calcium ion binding
- Gene Name
- F10
- Uniprot ID
- P00742
- Uniprot Name
- Coagulation factor X
- Molecular Weight
- 54731.255 Da
References
- BLATRIX C, SOULIER JP: [Preparation of a fraction rich in prothrombin, proconvertin, Stuart factor and antihemophilic factor B (P.P.B. fraction)]. Pathol Biol (Paris). 1959 Dec;7:2477-86. [Article]
- LUNDBLAD RL, DAVIE EW: THE ACTIVATION OF STUART FACTOR (FACTOR X) BY ACTIVATED ANTIHEMOPHILIC FACTOR (ACTIVATED FACTOR 8). Biochemistry. 1965 Jan;4:113-20. [Article]
- Radnoff OD, Saito H: Inhibition of Hageman factor, plasma thromboplastin antecedent, thrombin and other clotting factors by phenylglyoxal hydrate (38500). Proc Soc Exp Biol Med. 1975 Jan;148(1):177-82. [Article]
- Orthner CL: Characterization of proteases in AHF concentrates: effect on factor VIII:von Willebrand protein as assessed by high-pressure gel permeation chromatography. J Lab Clin Med. 1984 Nov;104(5):816-28. [Article]
- Freedman J, Mody M, Lazarus AH, Dewar L, Song S, Blanchette VS, Garvey MB, Ofosu FA: Platelet activation and hypercoagulability following treatment with porcine factor VIII (HYATE:C). Am J Hematol. 2002 Mar;69(3):192-9. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Cofactor
- General Function
- Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa
- Specific Function
- calcium ion binding
- Gene Name
- F9
- Uniprot ID
- P00740
- Uniprot Name
- Coagulation factor IX
- Molecular Weight
- 51778.11 Da
References
- Hule V: [Factor IX inhibitor (antihemophilic factor B, PTC) in a woman]. Vnitr Lek. 1975 Mar;21(3):274-7. [Article]
- Yoshitake S, Schach BG, Foster DC, Davie EW, Kurachi K: Nucleotide sequence of the gene for human factor IX (antihemophilic factor B). Biochemistry. 1985 Jul 2;24(14):3736-50. [Article]
- LUNDBLAD RL, DAVIE EW: THE ACTIVATION OF ANTIHEMOPHILIC FACTOR (FACTOR 8) BY ACTIVATED CHRISTMAS FACTOR (ACTIVATED FACTOR9 9). Biochemistry. 1964 Nov;3:1720-5. [Article]
- Hoofnagle JH, Gerety RJ, Thiel J, Barker LF: The prevalence of hepatitis B surface antigen in commercially prepared plasma products. J Lab Clin Med. 1976 Jul;88(1):102-13. [Article]
- Prince AM, Horowitz B, Brotman B, Huima T, Richardson L, van den Ende MC: Inactivation of hepatitis B and Hutchinson strain non-A, non-B hepatitis viruses by exposure to Tween 80 and ether. Vox Sang. 1984;46(1):36-43. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Yes
- Actions
- Binder
- General Function
- Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma
- Specific Function
- collagen binding
- Gene Name
- VWF
- Uniprot ID
- P04275
- Uniprot Name
- von Willebrand factor
- Molecular Weight
- 309261.83 Da
References
- Shord SS, Lindley CM: Coagulation products and their uses. Am J Health Syst Pharm. 2000 Aug 1;57(15):1403-17; quiz 1418-20. [Article]
- Lillicrap D, Poon MC, Walker I, Xie F, Schwartz BA: Efficacy and safety of the factor VIII/von Willebrand factor concentrate, haemate-P/humate-P: ristocetin cofactor unit dosing in patients with von Willebrand disease. Thromb Haemost. 2002 Feb;87(2):224-30. [Article]
- Gill JC, Ewenstein BM, Thompson AR, Mueller-Velten G, Schwartz BA: Successful treatment of urgent bleeding in von Willebrand disease with factor VIII/VWF concentrate (Humate-P): use of the ristocetin cofactor assay (VWF:RCo) to measure potency and to guide therapy. Haemophilia. 2003 Nov;9(6):688-95. [Article]
- Smith KJ, Lusher JM, Cohen AR, Salzman P: Initial clinical experience with a new pasteurized monoclonal antibody purified factor VIIIC. Semin Hematol. 1990 Apr;27(2 Suppl 2):25-9. [Article]
- Altieri DC, Capitanio AM, Mannucci PM: von Willebrand factor contaminating porcine factor VIII concentrate (Hyate:C) causes platelet aggregation. Br J Haematol. 1986 Aug;63(4):703-11. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Antagonist
- General Function
- Catalyzes the 2-hydroxylation of not only racemic phytanoyl-CoA and the isomers of 3-methylhexadecanoyl-CoA, but also a variety of other mono-branched 3-methylacyl-CoA esters (with a chain length of at least seven carbon atoms) and straight-chain acyl-CoA esters (with a chain length longer than four carbon atoms) (PubMed:10744784, PubMed:12031666, PubMed:12923223, PubMed:9326939). Does not hydroxylate long and very long straight chain acyl-CoAs or 2-methyl- and 4-methyl-branched acyl-CoAs (PubMed:10744784, PubMed:12923223)
- Specific Function
- carboxylic acid binding
- Gene Name
- PHYH
- Uniprot ID
- O14832
- Uniprot Name
- Phytanoyl-CoA dioxygenase, peroxisomal
- Molecular Weight
- 38538.065 Da
References
- Chen C, Wang Q, Fang X, Xu Q, Chi C, Gu J: Roles of phytanoyl-CoA alpha-hydroxylase in mediating the expression of human coagulation factor VIII. J Biol Chem. 2001 Dec 7;276(49):46340-6. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Binder
- General Function
- Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface
- Specific Function
- asialoglycoprotein receptor activity
- Gene Name
- ASGR2
- Uniprot ID
- P07307
- Uniprot Name
- Asialoglycoprotein receptor 2
- Molecular Weight
- 35092.04 Da
References
- Bovenschen N, Rijken DC, Havekes LM, van Vlijmen BJ, Mertens K: The B domain of coagulation factor VIII interacts with the asialoglycoprotein receptor. J Thromb Haemost. 2005 Jun;3(6):1257-65. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Chaperone
- General Function
- Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:1550958, PubMed:19538957). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (PubMed:26045166)
- Specific Function
- ATP binding
- Gene Name
- HSPA5
- Uniprot ID
- P11021
- Uniprot Name
- Endoplasmic reticulum chaperone BiP
- Molecular Weight
- 72332.425 Da
References
- Kaufman RJ, Pipe SW, Tagliavacca L, Swaroop M, Moussalli M: Biosynthesis, assembly and secretion of coagulation factor VIII. Blood Coagul Fibrinolysis. 1997 Dec;8 Suppl 2:S3-14. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Chaperone
- General Function
- Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (PubMed:7876246). Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (PubMed:11149926). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity)
- Specific Function
- calcium ion binding
- Gene Name
- CALR
- Uniprot ID
- P27797
- Uniprot Name
- Calreticulin
- Molecular Weight
- 48141.2 Da
References
- Pipe SW, Morris JA, Shah J, Kaufman RJ: Differential interaction of coagulation factor VIII and factor V with protein chaperones calnexin and calreticulin. J Biol Chem. 1998 Apr 3;273(14):8537-44. [Article]
- Srour MA, Grupp J, Aburubaiha Z, Albert T, Brondke H, Oldenburg J, Schwaab R: Modified expression of coagulation factor VIII by addition of a glycosylation site at the N terminus of the protein. Ann Hematol. 2008 Feb;87(2):107-12. Epub 2007 Sep 26. [Article]
- Kaufman RJ, Pipe SW, Tagliavacca L, Swaroop M, Moussalli M: Biosynthesis, assembly and secretion of coagulation factor VIII. Blood Coagul Fibrinolysis. 1997 Dec;8 Suppl 2:S3-14. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Chaperone
- General Function
- Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse
- Specific Function
- calcium ion binding
- Gene Name
- CANX
- Uniprot ID
- P27824
- Uniprot Name
- Calnexin
- Molecular Weight
- 67567.695 Da
References
- Pipe SW, Morris JA, Shah J, Kaufman RJ: Differential interaction of coagulation factor VIII and factor V with protein chaperones calnexin and calreticulin. J Biol Chem. 1998 Apr 3;273(14):8537-44. [Article]
- Becker S, Simpson JC, Pepperkok R, Heinz S, Herder C, Grez M, Seifried E, Tonn T: Confocal microscopy analysis of native, full length and B-domain deleted coagulation factor VIII trafficking in mammalian cells. Thromb Haemost. 2004 Jul;92(1):23-35. [Article]
- Srour MA, Grupp J, Aburubaiha Z, Albert T, Brondke H, Oldenburg J, Schwaab R: Modified expression of coagulation factor VIII by addition of a glycosylation site at the N terminus of the protein. Ann Hematol. 2008 Feb;87(2):107-12. Epub 2007 Sep 26. [Article]
- Kaufman RJ, Pipe SW, Tagliavacca L, Swaroop M, Moussalli M: Biosynthesis, assembly and secretion of coagulation factor VIII. Blood Coagul Fibrinolysis. 1997 Dec;8 Suppl 2:S3-14. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Chaperone
- General Function
- Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins
- Specific Function
- D-mannose binding
- Gene Name
- LMAN1
- Uniprot ID
- P49257
- Uniprot Name
- Protein ERGIC-53
- Molecular Weight
- 57548.665 Da
References
- Cunningham MA, Pipe SW, Zhang B, Hauri HP, Ginsburg D, Kaufman RJ: LMAN1 is a molecular chaperone for the secretion of coagulation factor VIII. J Thromb Haemost. 2003 Nov;1(11):2360-7. [Article]
- Miao HZ, Sirachainan N, Palmer L, Kucab P, Cunningham MA, Kaufman RJ, Pipe SW: Bioengineering of coagulation factor VIII for improved secretion. Blood. 2004 May 1;103(9):3412-9. Epub 2004 Jan 15. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Modulator
- General Function
- Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells (PubMed:11907044, PubMed:12713657). Required for early embryonic development (By similarity). Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an LRPAP1 alpha-2-macroglobulin receptor (PubMed:1702392, PubMed:26142438). Acts as TAU/MAPT receptor and controls the endocytosis of TAU/MAPT as well as its subsequent spread (PubMed:32296178). May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission (PubMed:12888553)
- Specific Function
- alpha-2 macroglobulin receptor activity
- Gene Name
- LRP1
- Uniprot ID
- Q07954
- Uniprot Name
- Prolow-density lipoprotein receptor-related protein 1
- Molecular Weight
- 504601.695 Da
References
- Franchini M, Montagnana M: Low-density lipoprotein receptor-related protein 1: new functions for an old molecule. Clin Chem Lab Med. 2011 Jun;49(6):967-70. doi: 10.1515/CCLM.2011.154. Epub 2011 Mar 11. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Modulator
- General Function
- The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. Plays a role in the secretion of coagulation factors
- Specific Function
- calcium ion binding
- Gene Name
- MCFD2
- Uniprot ID
- Q8NI22
- Uniprot Name
- Multiple coagulation factor deficiency protein 2
- Molecular Weight
- 16390.175 Da
References
- Zhang B, Kaufman RJ, Ginsburg D: LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway. J Biol Chem. 2005 Jul 8;280(27):25881-6. Epub 2005 May 10. [Article]
Enzymes
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Activator
- General Function
- Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Thrombin triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL8/CXCL8, in endothelial cells (PubMed:30568593, PubMed:9780208)
- Specific Function
- calcium ion binding
- Gene Name
- F2
- Uniprot ID
- P00734
- Uniprot Name
- Prothrombin
- Molecular Weight
- 70036.295 Da
References
- Alberio L, Safa O, Clemetson KJ, Esmon CT, Dale GL: Surface expression and functional characterization of alpha-granule factor V in human platelets: effects of ionophore A23187, thrombin, collagen, and convulxin. Blood. 2000 Mar 1;95(5):1694-702. [Article]
- Ratnoff OD, Lewis JH: Heckathorn's disease: variable functional dificiency of antihemophilic factor (factor VIII). Blood. 1975 Aug;46(2):161-73. [Article]
- Anderson DM, Shelley S, Crick N, Buraglio M: No effect of the novel antidiabetic agent nateglinide on the pharmacokinetics and anticoagulant properties of warfarin in healthy volunteers. J Clin Pharmacol. 2002 Dec;42(12):1358-65. [Article]
- Piet MP, Chin S, Prince AM, Brotman B, Cundell AM, Horowitz B: The use of tri(n-butyl)phosphate detergent mixtures to inactivate hepatitis viruses and human immunodeficiency virus in plasma and plasma's subsequent fractionation. Transfusion. 1990 Sep;30(7):591-8. [Article]
- Lazarchick J, Ashby MA, Lazarchick JJ, Sens DA: Mechanism of factor VIII inactivation by human antibodies. IV. Antibody binding prevents factor VIII proteolysis by thrombin. Ann Clin Lab Sci. 1986 Nov-Dec;16(6):497-501. [Article]
- Kind
- Protein
- Organism
- Humans
- Pharmacological action
- Unknown
- Actions
- Substrate
- General Function
- Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845)
- Specific Function
- calcium ion binding
- Gene Name
- PROC
- Uniprot ID
- P04070
- Uniprot Name
- Vitamin K-dependent protein C
- Molecular Weight
- 52070.82 Da
References
- Bereczky Z, Kovacs KB, Muszbek L: Protein C and protein S deficiencies: similarities and differences between two brothers playing in the same game. Clin Chem Lab Med. 2010 Dec;48 Suppl 1:S53-66. doi: 10.1515/CCLM.2010.369. Epub 2010 Nov 5. [Article]
Drug created at June 13, 2005 13:24 / Updated at October 17, 2024 13:59