Solute carrier family 12 member 5
Details
- Name
- Solute carrier family 12 member 5
- Kind
- protein
- Synonyms
- Electroneutral potassium-chloride cotransporter 2
- K-Cl cotransporter 2
- Kcc2
- Kiaa1176
- mKCC2
- Neuronal K-Cl cotransporter
- Gene Name
- Slc12a5
- UniProtKB Entry
- Q91V14Swiss-Prot
- Organism
- Mouse
- NCBI Taxonomy ID
- 10090
- Amino acid sequence
>lcl|BSEQ0052030|Solute carrier family 12 member 5 MSRRFTVTSLPPAASAASADPESRRHSVADPRRLPREDVKGDGNPKESSPFINSTDTEKG REYDGRNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRM GTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNG VVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAE DASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKS AFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRLLNATCDEYFTR NNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERRGMPSVGLADGTPVDMDHPYVFSDMT SYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACI EGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDG IVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACA VQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGA EKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQ LKAGKGLTIVGSVLEGTFLDNHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHL IQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGN PERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTT FLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDES RGSIRRKNPANPRLRLNVPEETACDNEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGER ETDPEVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNE VIVNKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEQLDRVMLVRGGGREVITIYS
- Number of residues
- 1138
- Molecular Weight
- 126269.555
- Theoretical pI
- Not Available
- GO Classification
- Functionsammonium transmembrane transporter activity / chloride transmembrane transporter activity / potassium / protein kinase bindingProcessesammonium transport / cell volume homeostasis / cellular chloride ion homeostasis / cellular ion homeostasis / chemical synaptic transmission / chloride ion homeostasis / chloride transmembrane transport / chloride transport / dendritic spine development / hypotonic response / intracellular pH reduction / ion transport / learning / multicellular organism growth / potassium ion homeostasis / potassium ion import across plasma membrane / potassium ion transport / response to drug / thermosensory behaviorComponentsdendrite membrane / dendritic shaft / integral component of membrane / integral component of plasma membrane / neuronal cell body / perikaryon / plasma membrane
- General Function
- Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (By similarity). As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (By similarity).
- Specific Function
- ammonium transmembrane transporter activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- 134-154 156-176 195-215 217-237 255-275 278-298 419-439 459-479 497-517 570-590 631-651 848-868
- Cellular Location
- Cell projection
- Gene sequence
>lcl|BSEQ0052031|Solute carrier family 12 member 5 (Slc12a5) ATGCTCAACAACCTGACGGACTGCGAGGACGGCGATGGGGGAGCCAACCCCGGTGATGGC AACCCCAAAGAGAGCAGTCCCTTCATCAACAGCACGGACACGGAGAAGGGCAGAGAGTAC GATGGCAGGAACATGGCCCTGTTTGAGGAGGAGATGGACACCAGCCCCATGGTATCCTCC CTGCTCAGTGGGCTGGCCAACTACACCAACCTACCCCAGGGAAGTAGAGAGCATGAAGAA GCAGAAAATAATGAGGGTGGAAAAAAGAAGCCGGTGCAGGCTCCTCGAATGGGCACCTTC ATGGGTGTGTACCTGCCGTGCCTGCAGAACATCTTTGGTGTCATCCTCTTCCTGCGGCTC ACGTGGGTGGTGGGCATCGCGGGCATCATGGAGTCCTTCTGTATGGTCTTCATTTGCTGC TCCTGTACGATGCTCACAGCCATTTCCATGAGTGCAATCGCAACCAATGGTGTTGTGCCT GCTGGTGGCTCGTACTACATGATTTCCAGGTCTCTGGGCCCGGAGTTTGGGGGCGCCGTG GGCCTCTGCTTCTACCTGGGCACCACCTTTGCTGGGGCTATGTACATCCTTGGCACGATC GAGATCCTGCTGGCTTATCTCTTCCCAGCTATGGCCATCTTCAAGGCAGAAGATGCCAGT GGGGAGGCGGCCGCCATGCTGAACAACATGCGGGTGTATGGCACCTGTGTGCTCACCTGC ATGGCCACCGTTGTCTTTGTGGGTGTCAAGTACGTCAACAAGTTTGCCTTGGTCTTCCTG GGTTGCGTCATCCTGTCCATCCTGGCCATCTATGCAGGGGTCATCAAGTCTGCCTTCGAC CCACCCAATTTCCCGATCTGCCTCCTGGGGAACCGCACGCTGTCTCGCCATGGCTTTGAT GTCTGTGCCAAGCTGGCTTGGGAAGGAAATGAGACAGTGACCACACGGCTCTGGGGCCTT TTCTGCTCCTCCCGCCTCCTCAATGCCACCTGTGATGAGTACTTCACCCGAAACAATGTC ACAGAGATCCAGGGCATTCCTGGTGCTGCCAGTGGTCTCATCAAAGAGAACCTGTGGAGT TCTTACCTGACCAAAGGGGTGATTGTCGAGAGGCGTGGGATGCCCTCTGTGGGCCTGGCA GACGGTACCCCCGTAGACATGGACCACCCCTATGTCTTCAGTGATATGACCTCCTACTTC ACCCTGCTCGTTGGTATCTACTTCCCCTCAGTCACAGGGATCATGGCTGGCTCAAACCGA TCTGGAGACCTGCGGGATGCCCAGAAGTCTATCCCTACTGGAACTATCCTGGCCATTGCT ACCACCTCTGCTGTCTACATCAGCTCTGTTGTTCTGTTTGGAGCCTGCATCGAGGGGGTC GTCTTACGGGACAAGTTTGGGGAAGCTGTGAATGGCAACTTGGTGGTGGGCACCCTGGCC TGGCCTTCTCCCTGGGTCATCGTCATAGGCTCTTTCTTCTCTACCTGTGGGGCTGGATTA CAGAGCCTCACAGGGGCCCCACGTCTGCTGCAGGCCATCTCCCGGGATGGCATAGTGCCC TTCCTGCAGGTCTTTGGCCATGGCAAAGCTAATGGAGAGCCAACCTGGGCGCTGCTGCTG ACTGCCTGCATCTGTGAGATCGGCATCCTCATAGCCTCCCTGGATGAGGTCGCCCCTATA CTTTCCATGTTCTTCCTAATGTGTTACATGTTTGTGAACTTGGCTTGTGCGGTGCAGACG CTGCTGAGGACACCCAACTGGAGGCCACGATTTCGCTATTACCACTGGACTCTCTCCTTC CTGGGCATGAGCCTCTGCCTGGCCCTCATGTTCATTTGCTCCTGGTACTACGCACTGGTG GCCATGCTCATTGCCGGACTCATTTATAAGTACATCGAGTACCGGGGGGCGGAGAAGGAG TGGGGGGATGGAATCCGAGGCCTGTCTCTCAGTGCAGCACGCTATGCTCTCTTGCGCCTG GAGGAAGGACCTCCGCATACGAAGAACTGGAGGCCCCAGCTGCTGGTGCTGGTGCGTGTG GACCAGGATCAGAACGTGGTGCATCCGCAGCTGCTCTCCCTGACCTCCCAGCTCAAGGCA GGGAAGGGCCTGACCATTGTGGGCTCCGTCCTTGAGGGCACCTTTCTGGACAACCATCCA CAGGCTCAGCGGGCAGAGGAGTCTATCAGGCGCCTGATGGAGGCTGAGAAGGTGAAGGGC TTCTGCCAGGTAGTGATCTCCTCCAACCTGCGTGATGGTGTGTCCCACCTGATCCAGTCT GGGGGCCTCGGGGGATTGCAACACAATACCGTGCTGGTGGGCTGGCCTCGCAACTGGAGG CAGAAGGAGGATCATCAGACATGGAGGAACTTCATCGAACTGGTCCGGGAAACTACAGCC GGCCACCTCGCCCTGCTGGTCACCAAGAATGTTTCCATGTTTCCCGGGAACCCTGAGCGC TTCTCGGAGGGCAGCATTGACGTGTGGTGGATTGTGCACGACGGGGGCATGCTCATGCTG CTGCCCTTCCTGCTGCGACACCACAAGGTCTGGAGGAAATGCAAAATGCGGATCTTCACC GTGGCCCAGATGGACGATAACAGTATCCAGATGAAGAAGGACCTGACCACGTTTCTGTAC CACTTACGCATTACTGCAGAGGTGGAGGTGGTGGAGATGCATGAGAGCGACATCTCGGCA TACACCTACGAGAAGACATTAGTAATGGAGCAACGATCTCAGATCCTCAAACAGATGCAC CTCACCAAGAACGAGCGGGAACGGGAGATCCAGAGCATCACAGACGAGTCTCGGGGCTCC ATTCGGAGGAAGAATCCAGCCAACCCCCGGCTCCGCCTCAATGTTCCCGAAGAGACAGCG TGTGACAATGAGGAGAAGCCAGAGGAGGAGGTGCAGCTGATCCATGACCAGAGTGCTCCC AGCTGCCCTAGCAGCTCGCCATCTCCAGGGGAGGAGCCCGAGGGGGAGAGGGAGACAGAC CCAGAGGTGCATCTTACCTGGACCAAGGATAAGTCAGTGGCAGAGAAGAATAAAGGCCCC AGTCCCGTCTCCTCCGAGGGCATCAAGGACTTCTTCAGCATGAAGCCGGAGTGGGAAAAC TTGAACCAGTCCAATGTACGGCGCATGCACACAGCTGTGCGGCTGAACGAGGTCATCGTG AATAAATCTCGGGATGCCAAGCTAGTTTTGCTCAACATGCCCGGGCCTCCCCGCAACCGC AATGGGGATGAAAACTACATGGAATTCTTGGAGGTCCTCACTGAGCAACTGGACCGGGTG ATGCTGGTCCGCGGTGGCGGCCGAGAGGTCATCACCATCTACTCCTGA
- Chromosome Location
- 2
- Locus
- 2 H3
- External Identifiers
Resource Link UniProtKB ID Q91V14 UniProtKB Entry Name S12A5_MOUSE KEGG ID mmu:57138 NCBI Gene ID 57138 - General References
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Finasteride approved unknown transporter modulator Details