Carbapenem-hydrolyzing beta-lactamase BlaB-1
Details
- Name
- Carbapenem-hydrolyzing beta-lactamase BlaB-1
- Kind
- protein
- Synonyms
- 3.5.2.6
- blaB
- CHbetaL-1
- Class B carbapenemase BlaB-1
- Gene Name
- blaB1
- UniProtKB Entry
- O08498Swiss-Prot
- Organism
- Elizabethkingia meningoseptica
- NCBI Taxonomy ID
- 238
- Amino acid sequence
>lcl|BSEQ0016867|Carbapenem-hydrolyzing beta-lactamase BlaB-1 MLKKIKISLILALGLTSLQAFGQENPDVKIEKLKDNLYVYTTYNTFNGTKYAANAVYLVT DKGVVVIDCPWGEDKFKSFTDEIYKKHGKKVIMNIATHSHDDRAGGLEYFGKIGAKTYST KMTDSILAKENKPRAQYTFDNNKSFKVGKSEFQVYYPGKGHTADNVVVWFPKEKVLVGGC IIKSADSKDLGYIGEAYVNDWTQSVHNIQQKFSGAQYVVAGHDDWKDQRSIQHTLDLINE YQQKQKASN
- Number of residues
- 249
- Molecular Weight
- 28143.82
- Theoretical pI
- 9.36
- GO Classification
- Functionsbeta-lactamase activity / zinc ion bindingProcessesantibiotic catabolic process / response to antibiotic
- General Function
- Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring.
- Specific Function
- beta-lactamase activity
- Pfam Domain Function
- Lactamase_B (PF00753)
- Signal Regions
- 1-22
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0005283|750 bp ATGTTGAAAAAAATAAAAATAAGCTTGATTCTTGCTCTTGGGCTTACCAGTTTGCAGGCA TTTGGACAGGAGAATCCTGATGTCAAAATTGAAAAGCTAAAAGATAATCTGTATGTATAC ACAACCTACAATACATTTAACGGGACTAAATATGCCGCAAATGCAGTATATCTGGTAACT GATAAGGGTGTTGTGGTTATAGACTGTCCGTGGGGAGAAGACAAATTTAAAAGCTTTACG GACGAGATTTATAAAAAACACGGAAAGAAAGTTATTATGAATATTGCAACACATTCTCAT GATGATCGTGCCGGAGGTCTTGAATATTTTGGTAAAATAGGTGCAAAAACTTATTCTACT AAAATGACAGATTCTATTTTAGCAAAAGAGAATAAGCCAAGAGCACAATATACTTTTGAC AATAATAAATCTTTCAAAGTAGGAAAATCCGAGTTTCAGGTTTACTATCCCGGAAAAGGG CACACAGCAGATAATGTGGTGGTATGGTTTCCAAAAGAAAAAGTATTGGTTGGAGGTTGT ATTATAAAAAGTGCTGATTCAAAGGACCTGGGGTATATTGGAGAAGCATATGTAAACGAC TGGACGCAGTCTGTACACAATATTCAACAAAAGTTTTCCGGTGCTCAGTACGTTGTTGCA GGGCATGATGATTGGAAAGATCAAAGATCAATACAACATACACTAGACTTAATCAATGAA TATCAACAAAAACAAAAGGCTTCAAATTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID O08498 UniProtKB Entry Name BLAB1_ELIME GenBank Gene ID X96858 PDB ID(s) 1M2X - General References
- Rossolini GM, Franceschini N, Riccio ML, Mercuri PS, Perilli M, Galleni M, Frere JM, Amicosante G: Characterization and sequence of the Chryseobacterium (Flavobacterium) meningosepticum carbapenemase: a new molecular class B beta-lactamase showing a broad substrate profile. Biochem J. 1998 May 15;332 ( Pt 1):145-52. [Article]
- Bellais S, Aubert D, Naas T, Nordmann P: Molecular and biochemical heterogeneity of class B carbapenem-hydrolyzing beta-lactamases in Chryseobacterium meningosepticum. Antimicrob Agents Chemother. 2000 Jul;44(7):1878-86. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Epicaptopril experimental unknown target Details