Cytidine deaminase
Details
- Name
- Cytidine deaminase
- Kind
- protein
- Synonyms
- 3.5.4.5
- CDD
- Cytidine aminohydrolase
- Gene Name
- CDA
- UniProtKB Entry
- P32320Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0011748|Cytidine deaminase MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACY PLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKP DGTYIVMTVQELLPSSFGPEDLQKTQ
- Number of residues
- 146
- Molecular Weight
- 16184.545
- Theoretical pI
- 6.95
- GO Classification
- Functionscytidine deaminase activity / nucleoside binding / protein homodimerization activity / zinc ion bindingProcessescell surface receptor signaling pathway / cytidine deamination / cytosine metabolic process / negative regulation of cell growth / negative regulation of nucleotide metabolic process / pyrimidine-containing compound salvageComponentscytosol / extracellular region
- General Function
- This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis
- Specific Function
- cytidine deaminase activity
- Pfam Domain Function
- dCMP_cyt_deam_1 (PF00383)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011749|Cytidine deaminase (CDA) ATGGCCCAGAAGCGTCCTGCCTGCACCCTGAAGCCTGAGTGTGTCCAGCAGCTGCTGGTT TGCTCCCAGGAGGCCAAGAAGTCAGCCTACTGCCCCTACAGTCACTTTCCTGTGGGGGCT GCCCTGCTCACCCAGGAGGGGAGAATCTTCAAAGGGTGCAACATAGAAAATGCCTGCTAC CCGCTGGGCATCTGTGCTGAACGGACCGCTATCCAGAAGGCCGTCTCAGAAGGGTACAAG GATTTCAGGGCAATTGCTATCGCCAGTGACATGCAAGATGATTTTATCTCTCCATGTGGG GCCTGCAGGCAAGTCATGAGAGAGTTTGGCACCAACTGGCCCGTGTACATGACCAAGCCG GATGGTACGTATATTGTCATGACGGTCCAGGAGCTGCTGCCCTCCTCCTTTGGGCCTGAG GACCTGCAGAAGACCCAGTGA
- Chromosome Location
- 1
- Locus
- 1p36.12
- External Identifiers
Resource Link UniProtKB ID P32320 UniProtKB Entry Name CDD_HUMAN GenBank Gene ID L27943 GeneCard ID CDA GenAtlas ID CDA HGNC ID HGNC:1712 PDB ID(s) 1MQ0 KEGG ID hsa:978 IUPHAR/Guide To Pharmacology ID 3133 NCBI Gene ID 978 - General References
- Laliberte J, Momparler RL: Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA. Cancer Res. 1994 Oct 15;54(20):5401-7. [Article]
- Demontis S, Terao M, Brivio M, Zanotta S, Bruschi M, Garattini E: Isolation and characterization of the gene coding for human cytidine deaminase. Biochim Biophys Acta. 1998 Dec 22;1443(3):323-33. [Article]
- Gran C, Boyum A, Johansen RF, Lovhaug D, Seeberg EC: Growth inhibition of granulocyte-macrophage colony-forming cells by human cytidine deaminase requires the catalytic function of the protein. Blood. 1998 Jun 1;91(11):4127-35. [Article]
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- Kuhn K, Bertling WM, Emmrich F: Cloning of a functional cDNA for human cytidine deaminase (CDD) and its use as a marker of monocyte/macrophage differentiation. Biochem Biophys Res Commun. 1993 Jan 15;190(1):1-7. [Article]
- Chung SJ, Fromme JC, Verdine GL: Structure of human cytidine deaminase bound to a potent inhibitor. J Med Chem. 2005 Feb 10;48(3):658-60. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 1-Beta-Ribofuranosyl-1,3-Diazepinone experimental unknown target Details Gemcitabine approved unknown enzyme substrate Details Cytarabine approved, investigational unknown enzyme substrate Details Azacitidine approved, investigational unknown enzyme substrate Details Capecitabine approved, investigational no enzyme substrate Details 1-Beta-Ribofuranosyl-1,3-Diazepinone experimental unknown enzyme ligand Details Cedazuridine approved, investigational yes target inhibitor Details Decitabine approved, investigational no enzyme substrate Details Tetrahydrouridine investigational yes target modulator Details