G protein-activated inward rectifier potassium channel 1
Details
- Name
- G protein-activated inward rectifier potassium channel 1
- Kind
- protein
- Synonyms
- GIRK-1
- GIRK1
- Inward rectifier K(+) channel Kir3.1
- Potassium channel, inwardly rectifying subfamily J member 3
- Gene Name
- KCNJ3
- UniProtKB Entry
- P48549Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0002047|G protein-activated inward rectifier potassium channel 1 MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNL GSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNY TPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCM FIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPE GEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILE GIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKE QEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMS STTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGG AARMEGNLPAKLRKMNSDRFT
- Number of residues
- 501
- Molecular Weight
- 56602.84
- Theoretical pI
- 8.36
- GO Classification
- Functionsvoltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential / voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization / voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationProcessesmembrane repolarization during atrial cardiac muscle cell action potential / potassium ion import across plasma membrane / potassium ion transmembrane transport / regulation of heart rate by cardiac conduction / regulation of monoatomic ion transmembrane transport / ventricular cardiac muscle cell membrane repolarizationComponentsI(KACh) inward rectifier potassium channel complex / parallel fiber to Purkinje cell synapse / presynaptic membrane
- General Function
- This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat
- Specific Function
- G-protein activated inward rectifier potassium channel activity
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- 81-105 158-179
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0010718|G protein-activated inward rectifier potassium channel 1 (KCNJ3) ATGTCTGCACTCCGAAGGAAATTTGGGGACGATTATCAGGTAGTGACCACATCGTCCAGC GGCTCGGGCTTGCAGCCCCAGGGGCCAGGCCAGGACCCTCAGCAGCAGCTTGTGCCCAAG AAGAAGCGGCAGCGGTTCGTGGACAAGAACGGCCGGTGCAATGTACAGCACGGCAACCTG GGCAGCGAGACAAGCCGCTACCTCTCGGACCTCTTCACCACGCTGGTGGACCTCAAGTGG CGCTGGAACCTCTTCATCTTCATTCTCACCTACACCGTGGCCTGGCTTTTCATGGCGTCC ATGTGGTGGGTGATCGCCTACACTCGGGGCGACCTGAACAAAGCCCACGTCGGTAACTAC ACGCCTTGCGTGGCCAATGTCTATAACTTCCCTTCTGCCTTCCTCTTCTTCATCGAGACG GAGGCCACCATCGGCTATGGCTACCGATACATCACAGACAAGTGCCCCGAGGGCATCATC CTCTTCCTCTTCCAGTCCATCCTGGGCTCCATCGTGGACGCCTTCCTCATCGGCTGCATG TTCATCAAGATGTCCCAGCCCAAGAAGCGCGCCGAGACCCTCATGTTCAGCGAGCACGCG GTGATCTCCATGAGGGACGGAAAACTCACGCTTATGTTCCGGGTGGGCAACCTGCGCAAC AGCCACATGGTCTCCGCGCAGATTCGCTGCAAGCTGCTCAAAGGATGA
- Chromosome Location
- 2
- Locus
- 2q24.1
- External Identifiers
Resource Link UniProtKB ID P48549 UniProtKB Entry Name KCNJ3_HUMAN GenBank Protein ID 1055028 GenBank Gene ID U39196 GeneCard ID KCNJ3 GenAtlas ID KCNJ3 HGNC ID HGNC:6264 KEGG ID hsa:3760 IUPHAR/Guide To Pharmacology ID 434 NCBI Gene ID 3760 - General References
- Chan KW, Langan MN, Sui JL, Kozak JA, Pabon A, Ladias JA, Logothetis DE: A recombinant inwardly rectifying potassium channel coupled to GTP-binding proteins. J Gen Physiol. 1996 Mar;107(3):381-97. [Article]
- Schoots O, Yue KT, MacDonald JF, Hampson DR, Nobrega JN, Dixon LM, Van Tol HH: Cloning of a G protein-activated inwardly rectifying potassium channel from human cerebellum. Brain Res Mol Brain Res. 1996 Jul;39(1-2):23-30. [Article]
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- Pabon A, Chan KW, Sui JL, Wu X, Logothetis DE, Thornhill WB: Glycosylation of GIRK1 at Asn119 and ROMK1 at Asn117 has different consequences in potassium channel function. J Biol Chem. 2000 Sep 29;275(39):30677-82. [Article]
Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Halothane approved, vet_approved unknown target inhibitor Details B-nonylglucoside experimental unknown target Details Ethanol approved unknown target Details Atomoxetine approved unknown target inhibitor Details Dronedarone approved yes target inhibitor Details Ifenprodil investigational, withdrawn unknown target antagonist Details