Glycine receptor subunit alpha-2

Details

Name
Glycine receptor subunit alpha-2
Kind
protein
Synonyms
Not Available
Gene Name
GLRA2
UniProtKB Entry
P23416Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0001486|Glycine receptor subunit alpha-2
MNRQLVNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDA
RIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLD
PSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFP
MDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGK
FTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQ
SSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNK
EEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDT
ISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
Number of residues
452
Molecular Weight
52001.585
Theoretical pI
9.2
GO Classification
Functions
extracellularly glycine-gated chloride channel activity / glycine-gated chloride ion channel activity / metal ion binding / neurotransmitter receptor activity / transmembrane signaling receptor activity / transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Processes
cellular response to amino acid stimulus / cellular response to ethanol / cellular response to zinc ion / monoatomic ion transmembrane transport
Components
glycinergic synapse / intracellular membrane-bounded organelle / transmembrane transporter complex
General Function
Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:15302677, PubMed:16144831, PubMed:2155780, PubMed:23895467, PubMed:25445488, PubMed:26370147, PubMed:34473954). Channel opening is also triggered by taurine and beta-alanine (PubMed:15302677). Plays a role in synaptic plasticity (By similarity). Contributes to the generation of inhibitory postsynaptic currents, and is involved in the down-regulation of neuronal excitability (PubMed:25445488). Plays a role in cellular responses to ethanol (PubMed:23895467)
Specific Function
Extracellularly glycine-gated chloride channel activity
Pfam Domain Function
Signal Regions
1-27
Transmembrane Regions
257-278 284-304 316-336 421-441
Cellular Location
Postsynaptic cell membrane
Gene sequence
>lcl|BSEQ0010525|Glycine receptor subunit alpha-2 (GLRA2)
ATGAACCGGCAGCTAGTGAACATTTTGACAGCCTTGTTTGCATTTTTCTTAGAGACAAAC
CACTTCAGGACGGCTTTCTGCAAAGACCATGACTCCAGGTCTGGAAAACAACCTTCACAG
ACCCTATCTCCTTCAGATTTCTTGGACAAGTTAATGGGAAGGACATCAGGATATGATGCA
AGAATCAGGCCAAATTTTAAAGGTCCTCCAGTAAACGTTACTTGCAATATTTTTATCAAC
AGTTTTGGATCAGTCACAGAAACGACCATGGACTACCGAGTGAATATTTTTCTGAGACAA
CAGTGGAATGATTCACGGCTGGCGTACAGTGAGTACCCAGATGACTCCCTGGACTTGGAC
CCATCCATGCTAGACTCCATTTGGAAACCAGATTTGTTCTTTGCCAATGAGAAGGGTGCC
AACTTCCACGATGTCACCACTGACAACAAATTGCTACGGATTTCGAAAAATGGCAAAGTG
CTCTACAGTATCAGACTCACCTTGACCTTATCCTGTCCCATGGACTTGAAGAACTTTCCG
ATGGATGTCCAGACCTGTACAATGCAGCTGGAGAGTTTTGGGTACACGATGAATGACCTG
ATATTTGAGTGGTTAAGTGATGGTCCAGTGCAAGTTGCTGAAGGATTGACCCTGCCCCAG
TTTATTTTGAAAGAAGAGAAGGAACTTGGCTACTGTACAAAGCACTACAACACTGGAAAG
TTTACCTGCATTGAGGTCAAGTTTCATCTGGAACGCCAAATGGGATATTATTTGATCCAG
ATGTACATCCCAAGCCTGCTTATAGTAATTTTGTCCTGGGTTTCCTTTTGGATAAATATG
GATGCAGCCCCTGCCAGGGTCGCACTGGGCATCACCACAGTCTTAACGATGACCACCCAG
AGTTCAGGCTCCAGGGCATCTCTGCCAAAGGTCTCCTATGTAAAAGCGATTGACATCTGG
ATGGCGGTGTGCCTTCTGTTTGTGTTTGCTGCCTTACTGGAATACGCAGCGGTGAACTTC
GTCTCCAGGCAACACAAGGAGTTCCTGCGCCTCCGAAGAAGACAGAAGAGGCAGAATAAG
GAAGAAGACGTTACTCGTGAAAGTCGTTTTAATTTTAGCGGTTATGGGATGGGTCACTGC
CTCCAAGTGAAAGATGGAACAGCTGTCAAGGCCACACCTGCCAACCCACTCCCACAACCG
CCAAAAGATGGAGATGCTATCAAGAAGAAGTTTGTGGACCGGGCAAAAAGGATTGACACG
ATATCTCGAGCTGCCTTCCCATTGGCCTTCCTCATTTTCAACATCTTTTACTGGATCACA
TACAAGATCATTCGGCATGAAGATGTCCACAAGAAATAG
Chromosome Location
X
Locus
Xp22.2
External Identifiers
ResourceLink
UniProtKB IDP23416
UniProtKB Entry NameGLRA2_HUMAN
GenBank Protein ID31849
GenBank Gene IDX52008
GeneCard IDGLRA2
GenAtlas IDGLRA2
HGNC IDHGNC:4327
PDB ID(s)5BKF, 5BKG, 7KUY, 7L31
KEGG IDhsa:2742
IUPHAR/Guide To Pharmacology ID424
NCBI Gene ID2742
General References
  1. Grenningloh G, Schmieden V, Schofield PR, Seeburg PH, Siddique T, Mohandas TK, Becker CM, Betz H: Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes. EMBO J. 1990 Mar;9(3):771-6. [Article]
  2. Cummings CJ, Dahle EJ, Zoghbi HY: Analysis of the genomic structure of the human glycine receptor alpha2 subunit gene and exclusion of this gene as a candidate for Rett syndrome. Am J Med Genet. 1998 Jun 30;78(2):176-8. [Article]
  3. Miller PS, Harvey RJ, Smart TG: Differential agonist sensitivity of glycine receptor alpha2 subunit splice variants. Br J Pharmacol. 2004 Sep;143(1):19-26. Epub 2004 Aug 9. [Article]
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Glycineapproved, nutraceutical, vet_approvedunknowntargetligandDetails
EthanolapprovedyestargetagonistDetails
PicrotoxinexperimentalunknowntargetantagonistDetails
Lindaneapproved, withdrawnunknowntargetantagonistDetails
Taurineapproved, nutraceuticalyestargetagonistDetails
StrychnineexperimentalyestargetantagonistDetails
Ginkgolide AnutraceuticalyestargetinhibitorDetails
GavestinelinvestigationalyestargetmodulatorDetails
ThiocolchicosideexperimentalyestargetinhibitorDetails