Fibroblast growth factor 1

Details

Name
Fibroblast growth factor 1
Kind
protein
Synonyms
  • Acidic fibroblast growth factor
  • aFGF
  • ECGF
  • Endothelial cell growth factor
  • FGF-1
  • FGFA
  • HBGF-1
  • Heparin-binding growth factor 1
Gene Name
FGF1
UniProtKB Entry
P05230Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0001374|Fibroblast growth factor 1
MAEGEITTFTALTEKFNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQ
LSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEK
NWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD
Number of residues
155
Molecular Weight
17459.58
Theoretical pI
7.04
GO Classification
Functions
fibroblast growth factor receptor binding / growth factor activity / heparin binding / S100 protein binding
Processes
anatomical structure morphogenesis / angiogenesis / branch elongation involved in ureteric bud branching / cellular response to heat / fibroblast growth factor receptor signaling pathway / lung development / mesonephric epithelium development / organ induction / positive regulation of angiogenesis / positive regulation of cell division / positive regulation of cell migration / positive regulation of cholesterol biosynthetic process / positive regulation of ERK1 and ERK2 cascade / positive regulation of intracellular signal transduction / positive regulation of MAP kinase activity / regulation of endothelial cell chemotaxis to fibroblast growth factor / signal transduction
Components
cell cortex / cytosol / extracellular region / extracellular space / nucleoplasm
General Function
Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107)
Specific Function
fibroblast growth factor receptor binding
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0021840|Fibroblast growth factor 1 (FGF1)
ATGGCTGAAGGGGAAATCACCACCTTCACAGCCCTGACCGAGAAGTTTAATCTGCCTCCA
GGGAATTACAAGAAGCCCAAACTCCTCTACTGTAGCAACGGGGGCCACTTCCTGAGGATC
CTTCCGGATGGCACAGTGGATGGGACAAGGGACAGGAGCGACCAGCACATTCAGCTGCAG
CTCAGTGCGGAAAGCGTGGGGGAGGTGTATATAAAGAGTACCGAGACTGGCCAGTACTTG
GCCATGGACACCGACGGGCTTTTATACGGCTCACAGACACCAAATGAGGAATGTTTGTTC
CTGGAAAGGCTGGAGGAGAACCATTACAACACCTATATATCCAAGAAGCATGCAGAGAAG
AATTGGTTTGTTGGCCTCAAGAAGAATGGGAGCTGCAAACGCGGTCCTCGGACTCACTAT
GGCCAGAAAGCAATCTTGTTTCTCCCCCTGCCAGTCTCTTCTGATTAA
Chromosome Location
5
Locus
5q31.3
External Identifiers
ResourceLink
UniProtKB IDP05230
UniProtKB Entry NameFGF1_HUMAN
GenBank Protein ID181942
GenBank Gene IDM13361
GeneCard IDFGF1
GenAtlas IDFGF1
HGNC IDHGNC:3665
PDB ID(s)1AXM, 1DJS, 1DZC, 1DZD, 1E0O, 1EVT, 1HKN, 1JQZ, 1JT3, 1JT4, 1JT5, 1JT7, 1JTC, 1JY0, 1K5U, 1K5V, 1M16, 1NZK, 1P63, 1PZZ, 1Q03, 1Q04, 1RG8, 1RML, 1RY7, 1YTO, 1Z2V, 1Z4S, 2AFG, 2AQZ, 2AXM, 2ERM, 2HW9, 2HWA, 2HWM, 2HZ9, 2K43, 2K4A, 2K8R, 2KI4, 2KI6, 2NTD, 2Q9X, 2RQ9, 3B9U, 3BA4, 3BA5, 3BA7, 3BAD, 3BAG, 3BAH, 3BAO, 3BAQ, 3BAU, 3BAV, 3BB2, 3CQA, 3CRG, 3CRH, 3CRI, 3CU1, 3FGM, 3FJ8, 3FJ9, 3FJA, 3FJB, 3FJC, 3FJD, 3FJE, 3FJF, 3FJH, 3FJI, 3FJJ, 3FJK, 3HOM, 3JUT, 3K1X, 3O3Q, 3OJ2, 3OJM, 3OJV, 3UD7, 3UD8, 3UD9, 3UDA, 4J23, 4Q91, 4Q9G, 4Q9P, 4QAL, 4QBC, 4QBV, 4QC4, 4QO3, 4XKI, 4YOL
KEGG IDhsa:2246
NCBI Gene ID2246
General References
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Pentosan polysulfateapprovedyestargetantagonistDetails
SucrosofateexperimentalyestargetinhibitorDetails
Formic acidexperimental, investigationalyestargetinhibitorDetails
O2-Sulfo-Glucuronic AcidexperimentalunknowntargetDetails
N,O6-Disulfo-GlucosamineexperimentalyestargetinhibitorDetails
Naphthalene TrisulfonateexperimentalyestargetinhibitorDetails
5-aminonaphthalene-2-sulfonic acidexperimentalyestargetinhibitorDetails
Amlexanoxapproved, investigational, withdrawnunknowntargetinhibitorDetails
PazopanibapprovedunknowntargetinhibitorDetails
Heparinapproved, investigationalunknowntargetDetails
Foreskin fibroblast (neonatal)approvedunknowntargetagonistDetails
Foreskin keratinocyte (neonatal)approvedyestargetagonistDetails