Thyroid hormone receptor alpha
Details
- Name
- Thyroid hormone receptor alpha
- Kind
- protein
- Synonyms
- c-erbA-1
- c-erbA-alpha
- EAR-7
- EAR7
- ERBA1
- NR1A1
- Nuclear receptor subfamily 1 group A member 1
- THRA1
- THRA2
- V-erbA-related protein 7
- Gene Name
- THRA
- UniProtKB Entry
- P10827Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0001370|Thyroid hormone receptor alpha MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKA TGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGM AMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNA QGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFS ELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIF ELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNI PHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQL GEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVC EDLAGNAASP
- Number of residues
- 490
- Molecular Weight
- 54815.055
- Theoretical pI
- 6.85
- GO Classification
- Functionschromatin DNA binding / protein domain specific binding / TBP-class protein binding / thyroid hormone binding / zinc ion bindingProcessescartilage condensation / erythrocyte differentiation / female courtship behavior / hormone-mediated signaling pathway / learning or memory / ossification / positive regulation of female receptivity / regulation of heart contraction / regulation of lipid catabolic process / regulation of myeloid cell apoptotic process / regulation of thyroid hormone mediated signaling pathway / response to cold / thyroid gland development / Type I pneumocyte differentiationComponentscytosol / nucleoplasm / nucleus
- General Function
- Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine
- Specific Function
- chromatin DNA binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Nucleus
- Gene sequence
>lcl|BSEQ0016176|Thyroid hormone receptor alpha (THRA) ATGGAACAGAAGCCAAGCAAGGTGGAGTGTGGGTCAGACCCAGAGGAGAACAGTGCCAGG TCACCAGATGGAAAGCGAAAAAGAAAGAACGGCCAATGTTCCCTGAAAACCAGCATGTCA GGGTATATCCCTAGTTACCTGGACAAAGACGAGCAGTGTGTCGTGTGTGGGGACAAGGCA ACTGGTTATCACTACCGCTGTATCACTTGTGAGGGCTGCAAGGGCTTCTTTCGCCGCACA ATCCAGAAGAACCTCCATCCCACCTATTCCTGCAAATATGACAGCTGCTGTGTCATTGAC AAGATCACCCGCAATCAGTGCCAGCTGTGCCGCTTCAAGAAGTGCATCGCCGTGGGCATG GCCATGGACTTGGTTCTAGATGACTCGAAGCGGGTGGCCAAGCGTAAGCTGATTGAGCAG AACCGGGAGCGGCGGCGGAAGGAGGAGATGATCCGATCACTGCAGCAGCGACCAGAGCCC ACTCCTGAAGAGTGGGATCTGATCCACATTGCCACAGAGGCCCATCGCAGCACCAATGCC CAGGGCAGCCATTGGAAACAGAGGCGGAAATTCCTGCCCGATGACATTGGCCAGTCACCC ATTGTCTCCATGCCGGACGGAGACAAGGTGGACCTGGAAGCCTTCAGCGAGTTTACCAAG ATCATCACCCCGGCCATCACCCGTGTGGTGGACTTTGCCAAAAAACTGCCCATGTTCTCC GAGCTGCCTTGCGAAGACCAGATCATCCTCCTGAAGGGGTGCTGCATGGAGATCATGTCC CTGCGGGCGGCTGTCCGCTACGACCCTGAGAGCGACACCCTGACGCTGAGTGGGGAGATG GCTGTCAAGCGGGAGCAGCTCAAGAATGGCGGCCTGGGCGTAGTCTCCGACGCCATCTTT GAACTGGGCAAGTCACTCTCTGCCTTTAACCTGGATGACACGGAAGTGGCTCTGCTGCAG GCTGTGCTGCTAATGTCAACAGACCGCTCGGGCCTGCTGTGTGTGGACAAGATCGAGAAG AGTCAGGAGGCGTACCTGCTGGCGTTCGAGCACTACGTCAACCACCGCAAACACAACATT CCGCACTTCTGGCCCAAGCTGCTGATGAAGGGTCCGCAGGTCCGGCAGCTTGAGCAGCAG CTTGGTGAAGCGGGAAGTCTCCAAGGGCCGGTTCTTCAGCACCAGAGCCCGAAGAGCCCG CAGCAGCGTCTCCTGGAGCTGCTCCACCGAAGCGGAATTCTCCATGCCCGAGCGGTCTGT GGGGAAGACGACAGCAGTGAGGCGGACTCCCCGAGCTCCTCTGAGGAGGAACCGGAGGTC TGCGAGGACCTGGCAGGCAATGCAGCCTCTCCCTGA
- Chromosome Location
- 17
- Locus
- 17q21.1
- External Identifiers
Resource Link UniProtKB ID P10827 UniProtKB Entry Name THA_HUMAN GenBank Protein ID 825639 GenBank Gene ID X55074 GeneCard ID THRA GenAtlas ID THRA HGNC ID HGNC:11796 PDB ID(s) 1NAV, 2H77, 2H79, 3HZF, 3ILZ, 3JZB, 4LNW, 4LNX, 7QDT KEGG ID hsa:7067 IUPHAR/Guide To Pharmacology ID 588 NCBI Gene ID 7067 - General References
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Associated Data
- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Liothyronine approved, vet_approved yes target agonist Details Levothyroxine approved yes target agonist Details NRP409 investigational unknown target Details Eprotirome investigational unknown target Details KB-141 experimental unknown target Details Liotrix approved yes target agonist Details Dextrothyroxine approved, investigational yes target agonist Details Dronedarone approved no target inhibitor Details Thyroid, porcine approved yes target substrate Details Tiratricol investigational yes target agonist Details