Choline-phosphate cytidylyltransferase B

Details

Name
Choline-phosphate cytidylyltransferase B
Kind
protein
Synonyms
  • 2.7.7.15
  • CCT B
  • CCT-beta
  • CCTB
  • CT B
  • CTP:phosphocholine cytidylyltransferase B
  • Phosphorylcholine transferase B
Gene Name
PCYT1B
UniProtKB Entry
Q9Y5K3Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0000986|Choline-phosphate cytidylyltransferase B
MPVVTTDAESETGIPKSLSNEPPSETMEEIEHTCPQPRLTLTAPAPFADETNCQCQAPHE
KLTIAQARLGTPADRPVRVYADGIFDLFHSGHARALMQAKTLFPNSYLLVGVCSDDLTHK
FKGFTVMNEAERYEALRHCRYVDEVIRDAPWTLTPEFLEKHKIDFVAHDDIPYSSAGSDD
VYKHIKEAGMFVPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKRY
RFQNQVDKMKEKVKNVEERSKEFVNRVEEKSHDLIQKWEEKSREFIGNFLELFGPDGAWK
QMFQERSSRMLQALSPKQSPVSSPTRSRSPSRSPSPTFSWLPLKTSPPSSPKAASASISS
MSEGDEDEK
Number of residues
369
Molecular Weight
41939.76
Theoretical pI
6.36
GO Classification
Functions
choline-phosphate cytidylyltransferase activity
Processes
CDP-choline pathway / ovarian follicle development / phosphatidylcholine biosynthetic process / spermatogenesis
Components
cytoplasm / endoplasmic reticulum membrane
General Function
Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis
Specific Function
choline-phosphate cytidylyltransferase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0010347|Choline-phosphate cytidylyltransferase B (PCYT1B)
ATGGTAGGCCATCAGGAGTGCATCATGGAAGAGGACAATCGCGCTCCCCAATTGTGGCGC
AAGACCCTGACTGCACCTGCCCCATTTGCTGATGAAACCAACTGCCAGTGTCAAGCACCC
CATGAAAAACTGACCATTGCTCAGGCCCGCTTAGGAACACCAGCTGACAGGCCTGTCAGA
GTATACGCCGATGGAATATTTGACCTCTTCCACTCAGGTCATGCAAGAGCCCTTATGCAA
GCAAAAACACTGTTTCCCAACAGCTACTTGTTGGTAGGAGTTTGCAGTGATGATCTCACC
CACAAATTCAAAGGTTTCACCGTGATGAATGAAGCCGAGAGATACGAAGCTCTCAGACAC
TGTCGCTACGTAGACGAAGTTATCAGAGATGCTCCCTGGACACTCACGCCAGAGTTTCTG
GAAAAACACAAGATTGACTTTGTGGCTCATGATGACATTCCGTATTCCTCTGCTGGCTCT
GATGATGTTTACAAGCACATAAAGGAAGCAGGGATGTTCGTTCCAACGCAGAGAACAGAA
GGCATCTCAACATCGGACATCATTACCAGAATTGTTCGTGACTATGATGTTTATGCCCGA
CGTAACCTCCAGAGAGGGTATACAGCCAAGGAACTGAATGTCAGCTTTATAAATGAGAAG
AGGTACCGTTTCCAGAACCAAGTGGACAAAATGAAGGAAAAAGTCAAGAATGTGGAGGAA
AGATCAAAGGAATTTGTGAACAGAGTGGAAGAAAAGAGCCATGATCTAATTCAAAAGTGG
GAAGAGAAGTCAAGGGAATTCATTGGCAACTTCCTAGAACTGTTTGGACCTGATGGAGCA
TGGAAGCAGATGTTCCAGGAGAGGAGCAGCCGGATGCTGCAGGCCTTATCCCCGAAGCAG
AGCCCTGTGAGCAGCCCAACCCGGAGCCGGTCCCCTTCCCGCTCCCCATCGCCCACCTTC
TCATGGCTTCCACTCAAAACCTCACCCCCTTCCTCACCCAAAGCAGCCTCAGCCTCTATC
AGCAGCATGAGCGAGGGGGATGAGGATGAAAAGTAG
Chromosome Location
X
Locus
Xp22.11
External Identifiers
ResourceLink
UniProtKB IDQ9Y5K3
UniProtKB Entry NamePCY1B_HUMAN
GenBank Protein ID3153239
GenBank Gene IDAF052510
GeneCard IDPCYT1B
GenAtlas IDPCYT1B
HGNC IDHGNC:8755
KEGG IDhsa:9468
NCBI Gene ID9468
General References
  1. Lykidis A, Murti KG, Jackowski S: Cloning and characterization of a second human CTP:phosphocholine cytidylyltransferase. J Biol Chem. 1998 May 29;273(22):14022-9. [Article]
  2. Lykidis A, Baburina I, Jackowski S: Distribution of CTP:phosphocholine cytidylyltransferase (CCT) isoforms. Identification of a new CCTbeta splice variant. J Biol Chem. 1999 Sep 17;274(38):26992-7001. [Article]
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Cholineapproved, nutraceuticalunknowntargetproduct ofDetails
Choline salicylateapproved, nutraceuticalunknowntargetproduct ofDetails
Cholesterolapproved, investigationalyestargetactivatorDetails
CT-2584investigationalyestargetmodulatorDetails
SphingosineexperimentalyestargetinhibitorDetails