Studies on the effects of low-molecular uraemic toxins on the activity of 3-phospho-D-glycerol aldehyde dehydrogenase (E.C.1.2.1.12) in human erythrocytes.
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Kopczynski Z, Dryl T, Chmiel J
Studies on the effects of low-molecular uraemic toxins on the activity of 3-phospho-D-glycerol aldehyde dehydrogenase (E.C.1.2.1.12) in human erythrocytes.
Acta Physiol Pol. 1984 Sep-Dec;35(5-6):539-45.
- PubMed ID
- 6100768 [ View in PubMed]
- Abstract
The effects of known low-molecular uraemic toxins, such as guanidine, guanidinoacetic acid, creatinine, ornithine, or urea, on the activity of 3-phosphoglycerol aldehyde dehydrogenase (GDH) were studied in normal human erythrocytes. The study was carried out in vitro. Cyclic adenosine monophosphate in doses exceeding its physiological concentration was found also to exert an effect on GDH activity. The study demonstrated that various toxins affected the activity of the enzyme in various degrees depending on the type of the toxin and its concentration. Cyclic AMP in a concentration approximating that in the plasma of uraemic patients (10(-6) mol/l) inhibited 32.8% of GDH in the erythrocytes. A similar phenomenon was demonstrated also when the studied substances were given jointly.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Guanidine Aldehyde dehydrogenase, mitochondrial Protein Humans YesInhibitorDetails