diff --git a/packages/eslint-plugin/docs/rules/consistent-generic-constructors.mdx b/packages/eslint-plugin/docs/rules/consistent-generic-constructors.mdx
index e4c5e0708398..0426691ef469 100644
--- a/packages/eslint-plugin/docs/rules/consistent-generic-constructors.mdx
+++ b/packages/eslint-plugin/docs/rules/consistent-generic-constructors.mdx
@@ -79,6 +79,37 @@ const set: Set<string> = new Set<string>();
 </TabItem>
 </Tabs>
 
+### `ignore`
+
+{/* insert option description */}
+
+Some constructors have different type signatures between their type and value, for example like Uint8Array.
+
+<Tabs>
+<TabItem value="❌ Incorrect">
+
+```ts option='"constructor"'
+// Incorrect because Uint8Array has deffenrent type signature and not in ignorelist
+let a: Uint8Array<ArrayBufferLike> = new Uint8Array();
+
+// Incorrect because type arguments appear in type-annotation and not in ignorelist
+let a: UserConstructor<Type> = new UserConstructor();
+```
+
+</TabItem>
+<TabItem value="✅ Correct">
+
+```ts option='"constructor", { "ignore": ["Uint8Array", "UserConstructor"] }' showPlaygroundButton
+// Correct because Uint8Array has deffenrent type signature but are included in the ignorelist.
+let a: Uint8Array<ArrayBufferLike> = new Uint8Array();
+
+// Correct because type arguments appear in type-annotations but are included in the ignorelist.
+let a: UserConstructor<Type> = new UserConstructor();
+```
+
+</TabItem>
+</Tabs>
+
 ## When Not To Use It
 
 You can turn this rule off if you don't want to enforce one kind of generic constructor style over the other.
diff --git a/packages/eslint-plugin/src/rules/consistent-generic-constructors.ts b/packages/eslint-plugin/src/rules/consistent-generic-constructors.ts
index a26f1422460e..471cf7ab68e2 100644
--- a/packages/eslint-plugin/src/rules/consistent-generic-constructors.ts
+++ b/packages/eslint-plugin/src/rules/consistent-generic-constructors.ts
@@ -4,8 +4,13 @@ import { AST_NODE_TYPES } from '@typescript-eslint/utils';
 
 import { createRule, nullThrows, NullThrowsReasons } from '../util';
 
-export type MessageIds = 'preferConstructor' | 'preferTypeAnnotation';
-export type Options = ['constructor' | 'type-annotation'];
+type MessageIds = 'preferConstructor' | 'preferTypeAnnotation';
+type Options = [
+  'constructor' | 'type-annotation',
+  {
+    ignore?: string[];
+  }?,
+];
 
 export default createRule<Options, MessageIds>({
   name: 'consistent-generic-constructors',
@@ -29,10 +34,24 @@ export default createRule<Options, MessageIds>({
         description: 'Which constructor call syntax to prefer.',
         enum: ['type-annotation', 'constructor'],
       },
+      {
+        type: 'object',
+        additionalProperties: false,
+        properties: {
+          ignore: {
+            type: 'array',
+            description:
+              'A list of constructor names to ignore when enforcing the rule.',
+            items: {
+              type: 'string',
+            },
+          },
+        },
+      },
     ],
   },
-  defaultOptions: ['constructor'],
-  create(context, [mode]) {
+  defaultOptions: ['constructor', {}],
+  create(context, [mode, options]) {
     return {
       'VariableDeclarator,PropertyDefinition,AccessorProperty,:matches(FunctionDeclaration,FunctionExpression) > AssignmentPattern'(
         node:
@@ -77,7 +96,8 @@ export default createRule<Options, MessageIds>({
           lhs &&
           (lhs.type !== AST_NODE_TYPES.TSTypeReference ||
             lhs.typeName.type !== AST_NODE_TYPES.Identifier ||
-            lhs.typeName.name !== rhs.callee.name)
+            lhs.typeName.name !== rhs.callee.name ||
+            options?.ignore?.includes(lhs.typeName.name))
         ) {
           return;
         }
diff --git a/packages/eslint-plugin/tests/docs-eslint-output-snapshots/consistent-generic-constructors.shot b/packages/eslint-plugin/tests/docs-eslint-output-snapshots/consistent-generic-constructors.shot
index 4bb5d2eb9433..ca6745508d9e 100644
--- a/packages/eslint-plugin/tests/docs-eslint-output-snapshots/consistent-generic-constructors.shot
+++ b/packages/eslint-plugin/tests/docs-eslint-output-snapshots/consistent-generic-constructors.shot
@@ -30,3 +30,23 @@ const map: Map<string, number> = new Map();
 const set: Set<string> = new Set();
 const set = new Set();
 const set: Set<string> = new Set<string>();
+
+Incorrect
+Options: "constructor"
+
+// Incorrect because Uint8Array has deffenrent type signature and not in ignorelist
+let a: Uint8Array<ArrayBufferLike> = new Uint8Array();
+    ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ The generic type arguments should be specified as part of the constructor type arguments.
+
+// Incorrect because type arguments appear in type-annotation and not in ignorelist
+let a: UserConstructor<Type> = new UserConstructor();
+    ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ The generic type arguments should be specified as part of the constructor type arguments.
+
+Correct
+Options: "constructor", { "ignore": ["Uint8Array", "UserConstructor"] }
+
+// Correct because Uint8Array has deffenrent type signature but are included in the ignorelist.
+let a: Uint8Array<ArrayBufferLike> = new Uint8Array();
+
+// Correct because type arguments appear in type-annotations but are included in the ignorelist.
+let a: UserConstructor<Type> = new UserConstructor();
diff --git a/packages/eslint-plugin/tests/rules/consistent-generic-constructors.test.ts b/packages/eslint-plugin/tests/rules/consistent-generic-constructors.test.ts
index 1a573186b1ae..61fd41fc150e 100644
--- a/packages/eslint-plugin/tests/rules/consistent-generic-constructors.test.ts
+++ b/packages/eslint-plugin/tests/rules/consistent-generic-constructors.test.ts
@@ -45,6 +45,10 @@ class A {
     `
 const a = function (a: Foo = new Foo<string>()) {};
     `,
+    {
+      code: 'let a: Uint8Array<ArrayBufferLike> = new Uint8Array();',
+      options: ['constructor', { ignore: ['Uint8Array'] }],
+    },
     {
       code: `
 const foo: Foo<string> = new Foo();
diff --git a/packages/eslint-plugin/tests/schema-snapshots/consistent-generic-constructors.shot b/packages/eslint-plugin/tests/schema-snapshots/consistent-generic-constructors.shot
index 9220d7089030..6c47fa111765 100644
--- a/packages/eslint-plugin/tests/schema-snapshots/consistent-generic-constructors.shot
+++ b/packages/eslint-plugin/tests/schema-snapshots/consistent-generic-constructors.shot
@@ -6,6 +6,19 @@
     "description": "Which constructor call syntax to prefer.",
     "enum": ["constructor", "type-annotation"],
     "type": "string"
+  },
+  {
+    "additionalProperties": false,
+    "properties": {
+      "ignore": {
+        "description": "A list of constructor names to ignore when enforcing the rule.",
+        "items": {
+          "type": "string"
+        },
+        "type": "array"
+      }
+    },
+    "type": "object"
   }
 ]
 
@@ -14,7 +27,13 @@
 
 type Options = [
   /** Which constructor call syntax to prefer. */
-  | 'type-annotation'
-  /** Which constructor call syntax to prefer. */
-  | 'constructor',
+  (
+    | 'type-annotation'
+    /** Which constructor call syntax to prefer. */
+    | 'constructor'
+  ),
+  {
+    /** A list of constructor names to ignore when enforcing the rule. */
+    ignore?: string[];
+  },
 ];