diff --git a/CHANGELOG.md b/CHANGELOG.md
index 96461ca68..63c409ff9 100644
--- a/CHANGELOG.md
+++ b/CHANGELOG.md
@@ -18,6 +18,7 @@ This document follows the conventions laid out in [Keep a CHANGELOG][].
 -   Added keyword arguments based on C# syntax for calling CPython methods (#461)
 
 ### Changed
+-   geninterop.py uses MSVC on Windows, gcc on Linux and CLang in other cases
 
 ### Fixed
 
diff --git a/tools/geninterop/fake_libc_include/basetsd.h b/tools/geninterop/fake_libc_include/basetsd.h
new file mode 100644
index 000000000..ed3102f68
--- /dev/null
+++ b/tools/geninterop/fake_libc_include/basetsd.h
@@ -0,0 +1,2 @@
+// for windows
+#define __declspec(x)
diff --git a/tools/geninterop/geninterop.py b/tools/geninterop/geninterop.py
index bf5fdb96b..1238ef14e 100644
--- a/tools/geninterop/geninterop.py
+++ b/tools/geninterop/geninterop.py
@@ -167,14 +167,22 @@ def preprocess_python_headers():
     include_dirs = [fake_libc_include]
 
     include_py = sysconfig.get_config_var("INCLUDEPY")
+    if (not (include_py == None)) and sys.platform.startswith('win32'):
+        include_dirs.append("-I")
     include_dirs.append(include_py)
-
-    defines = [
-        "-D", "__attribute__(x)=",
-        "-D", "__inline__=inline",
-        "-D", "__asm__=;#pragma asm",
-        "-D", "__int64=long long"
-    ]
+    
+    if sys.platform.startswith('win32'):
+        defines = [
+            "-D", "__cdecl=",
+            "-D", "__int64=long long"
+        ]
+    else:
+        defines = [
+            "-D", "__attribute__(x)=",
+            "-D", "__inline__=inline",
+            "-D", "__asm__=;#pragma asm",
+            "-D", "__int64=long long"
+        ]
 
     if hasattr(sys, "abiflags"):
         if "d" in sys.abiflags:
@@ -185,8 +193,14 @@ def preprocess_python_headers():
             defines.extend(("-D", "PYTHON_WITH_WIDE_UNICODE"))
 
     python_h = os.path.join(include_py, "Python.h")
-    cmd = ["clang", "-I"] + include_dirs + defines + ["-E", python_h]
-
+    if sys.platform.startswith('linux'):
+        compiler = "gcc"
+    elif sys.platform.startswith('win32'):
+        compiler = "cl.exe"
+    else:
+        compiler = "clang"
+    cmd = [compiler, "-I"] + include_dirs + defines + ["-E", python_h]
+    
     # normalize as the parser doesn't like windows line endings.
     lines = []
     for line in _check_output(cmd).splitlines():