diff --git a/Misc/NEWS.d/next/Build/2022-01-05-02-58-10.bpo-46263.xiv8NU.rst b/Misc/NEWS.d/next/Build/2022-01-05-02-58-10.bpo-46263.xiv8NU.rst
new file mode 100644
index 00000000000000..3a575ed7f556b8
--- /dev/null
+++ b/Misc/NEWS.d/next/Build/2022-01-05-02-58-10.bpo-46263.xiv8NU.rst
@@ -0,0 +1 @@
+``configure`` no longer sets ``MULTIARCH`` on FreeBSD platforms.
diff --git a/configure b/configure
index 1b1caf84de7d56..d078887b2f4856 100755
--- a/configure
+++ b/configure
@@ -5366,10 +5366,20 @@ $as_echo "none" >&6; }
 fi
 rm -f conftest.c conftest.out
 
-if test x$PLATFORM_TRIPLET != xdarwin; then
-  MULTIARCH=$($CC --print-multiarch 2>/dev/null)
-fi
+{ $as_echo "$as_me:${as_lineno-$LINENO}: checking for multiarch" >&5
+$as_echo_n "checking for multiarch... " >&6; }
+case $ac_sys_system in #(
+  Darwin*) :
+    MULTIARCH="" ;; #(
+  FreeBSD*) :
+    MULTIARCH="" ;; #(
+  *) :
+    MULTIARCH=$($CC --print-multiarch 2>/dev/null)
+ ;;
+esac
 
+{ $as_echo "$as_me:${as_lineno-$LINENO}: result: $MULTIARCH" >&5
+$as_echo "$MULTIARCH" >&6; }
 
 if test x$PLATFORM_TRIPLET != x && test x$MULTIARCH != x; then
   if test x$PLATFORM_TRIPLET != x$MULTIARCH; then
@@ -5379,6 +5389,7 @@ elif test x$PLATFORM_TRIPLET != x && test x$MULTIARCH = x; then
   MULTIARCH=$PLATFORM_TRIPLET
 fi
 
+
 if test x$MULTIARCH != x; then
   MULTIARCH_CPPFLAGS="-DMULTIARCH=\\\"$MULTIARCH\\\""
 fi
diff --git a/configure.ac b/configure.ac
index 823252be694256..431d66197bc7ff 100644
--- a/configure.ac
+++ b/configure.ac
@@ -882,10 +882,14 @@ else
 fi
 rm -f conftest.c conftest.out
 
-if test x$PLATFORM_TRIPLET != xdarwin; then
-  MULTIARCH=$($CC --print-multiarch 2>/dev/null)
-fi
-AC_SUBST(MULTIARCH)
+AC_MSG_CHECKING([for multiarch])
+AS_CASE([$ac_sys_system],
+  [Darwin*], [MULTIARCH=""],
+  [FreeBSD*], [MULTIARCH=""],
+  [MULTIARCH=$($CC --print-multiarch 2>/dev/null)]
+)
+AC_SUBST([MULTIARCH])
+AC_MSG_RESULT([$MULTIARCH])
 
 if test x$PLATFORM_TRIPLET != x && test x$MULTIARCH != x; then
   if test x$PLATFORM_TRIPLET != x$MULTIARCH; then
@@ -895,6 +899,7 @@ elif test x$PLATFORM_TRIPLET != x && test x$MULTIARCH = x; then
   MULTIARCH=$PLATFORM_TRIPLET
 fi
 AC_SUBST(PLATFORM_TRIPLET)
+
 if test x$MULTIARCH != x; then
   MULTIARCH_CPPFLAGS="-DMULTIARCH=\\\"$MULTIARCH\\\""
 fi