diff --git a/Lib/email/_header_value_parser.py b/Lib/email/_header_value_parser.py
index 5b653f66c18554..e4a342d446f6a3 100644
--- a/Lib/email/_header_value_parser.py
+++ b/Lib/email/_header_value_parser.py
@@ -949,6 +949,7 @@ class _InvalidEwError(errors.HeaderParseError):
 # up other parse trees.  Maybe should have  tests for that, too.
 DOT = ValueTerminal('.', 'dot')
 ListSeparator = ValueTerminal(',', 'list-separator')
+ListSeparator.as_ew_allowed = False
 RouteComponentMarker = ValueTerminal('@', 'route-component-marker')
 
 #
@@ -2022,7 +2023,7 @@ def get_address_list(value):
             address_list.defects.append(errors.InvalidHeaderDefect(
                 "invalid address in address-list"))
         if value:  # Must be a , at this point.
-            address_list.append(ValueTerminal(',', 'list-separator'))
+            address_list.append(ListSeparator)
             value = value[1:]
     return address_list, value
 
diff --git a/Lib/test/test_email/test__header_value_parser.py b/Lib/test/test_email/test__header_value_parser.py
index bdb0e55f21069f..f7e80749c456f8 100644
--- a/Lib/test/test_email/test__header_value_parser.py
+++ b/Lib/test/test_email/test__header_value_parser.py
@@ -2985,6 +2985,11 @@ def test_address_list_with_unicode_names_in_quotes(self):
             '=?utf-8?q?H=C3=BCbsch?= Kaktus <beautiful@example.com>,\n'
                 ' =?utf-8?q?bei=C3=9Ft_bei=C3=9Ft?= <biter@example.com>\n')
 
+    def test_address_list_with_list_separator_after_fold(self):
+        to = '0123456789' * 8 + '@foo, ä <foo@bar>'
+        self._test(parser.get_address_list(to)[0],
+                   '0123456789' * 8 + '@foo,\n =?utf-8?q?=C3=A4?= <foo@bar>\n')
+
     # XXX Need tests with comments on various sides of a unicode token,
     # and with unicode tokens in the comments.  Spaces inside the quotes
     # currently don't do the right thing.
diff --git a/Misc/NEWS.d/next/Library/2023-01-09-14-08-02.gh-issue-100884.DcmdLl.rst b/Misc/NEWS.d/next/Library/2023-01-09-14-08-02.gh-issue-100884.DcmdLl.rst
new file mode 100644
index 00000000000000..2a388178810835
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2023-01-09-14-08-02.gh-issue-100884.DcmdLl.rst
@@ -0,0 +1,2 @@
+email: fix misfolding of comma in address-lists over multiple lines in
+combination with unicode encoding.