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Re this thread:
https://forums.adafruit.com/viewtopic.php?f=60&t=174668
Maybe some weird edge case for this hardware combo? Used an Itsy M4 as a sanity check and it works fine there. Tested via REPL doing essentially the same I2C transaction as the library.
RPi pico
Adafruit CircuitPython 6.2.0-beta.1 on 2021-01-27; Raspberry Pi Pico with rp2040
>>> import board
>>> import busio
>>> i2c = busio.I2C(board.GP27, board.GP26)
>>> i2c.try_lock()
True
>>> buffer = bytearray(2)
>>> buffer[0] = 0x01 | 0x80
>>> buffer[1] = 100
>>> i2c.writeto(0x29, buffer)
Traceback (most recent call last):
File "<stdin>", line 1, in <module>
OSError: [Errno 19] Unsupported operation
>>> 
Itsy M4
Adafruit CircuitPython 6.1.0 on 2021-01-21; Adafruit ItsyBitsy M4 Express with samd51g19
>>> import board
>>> i2c = board.I2C()
>>> i2c.try_lock()
True
>>> buffer = bytearray(2)
>>> buffer[0] = 0x01 | 0x80
>>> buffer[1] = 100
>>> i2c.writeto(0x29, buffer)
>>> 