diff --git a/CMakeLists.txt b/CMakeLists.txt
index 161f97f8..3367848d 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -94,8 +94,8 @@ if(ITKPythonPackage_SUPERBUILD)
 
   set(ITK_REPOSITORY "https://github.com/InsightSoftwareConsortium/ITK.git")
 
-  # release-5.4 branch, 2025-06-23
-  set(ITK_GIT_TAG "46f39a0ea702247628036fc3cffdb009caa463cf")
+  # release-5.4 branch, 2025-11-21
+  set(ITK_GIT_TAG "v5.4.5")
 
   #-----------------------------------------------------------------------------
   # A separate project is used to download ITK, so that it can reused
diff --git a/itkVersion.py b/itkVersion.py
index ff7f3050..717bad72 100644
--- a/itkVersion.py
+++ b/itkVersion.py
@@ -1,4 +1,4 @@
-VERSION = '5.4.4.post1'
+VERSION = '5.4.5'
 
 def get_versions():
     """Returns versions for the ITK Python package.