diff --git a/src/metrics/kms-service.spec.ts b/src/metrics/kms-service.spec.ts
index a12e6106..6892884e 100644
--- a/src/metrics/kms-service.spec.ts
+++ b/src/metrics/kms-service.spec.ts
@@ -100,7 +100,7 @@ describe("KMSService", () => {
       });
 
     const kmsService = new KMSService();
-    const result = await kmsService.decryptV3(Buffer.from(ENCRYPTED_KEY, "base64"));
+    const result = await kmsService.decryptV3(Buffer.from(ENCRYPTED_KEY, "base64"), {});
     expect(Buffer.from(result).toString("ascii")).toEqual(EXPECTED_RESULT);
     fakeKmsCall.done();
   });
@@ -116,8 +116,34 @@ describe("KMSService", () => {
       });
 
     const kmsService = new KMSService();
-    const result = await kmsService.decryptV3(Buffer.from(ENCRYPTED_KEY, "base64"));
+    const result = await kmsService.decryptV3(Buffer.from(ENCRYPTED_KEY, "base64"), {});
     expect(Buffer.from(result).toString("ascii")).toEqual(EXPECTED_RESULT);
     fakeKmsCall.done();
   });
+
+  it("configures FIPS endpoint for GovCloud regions", async () => {
+    try {
+      process.env.AWS_REGION = "us-gov-west-1";
+
+      const mockKmsConstructor = jest.fn();
+      jest.mock("aws-sdk/clients/kms", () => mockKmsConstructor);
+      mockKmsConstructor.mockImplementation(() => ({
+        decrypt: () => ({
+          promise: () => Promise.resolve({ Plaintext: Buffer.from(EXPECTED_RESULT) }),
+        }),
+      }));
+
+      // Create service and call decrypt
+      const kmsService = new KMSService();
+      await kmsService.decrypt(ENCRYPTED_KEY);
+
+      // Verify FIPS endpoint was used
+      expect(mockKmsConstructor).toHaveBeenCalledWith({
+        endpoint: "https://kms-fips.us-gov-west-1.amazonaws.com",
+      });
+    } finally {
+      process.env.AWS_REGION = "us-east-1";
+      jest.restoreAllMocks();
+    }
+  });
 });
diff --git a/src/metrics/kms-service.ts b/src/metrics/kms-service.ts
index f4aab9b4..d10950f4 100644
--- a/src/metrics/kms-service.ts
+++ b/src/metrics/kms-service.ts
@@ -1,6 +1,8 @@
 // In order to avoid the layer adding the 40mb aws-sdk to a deployment, (which is always available
 // in the Lambda environment anyway), we use require to import the SDK.
 
+import { logDebug } from "../utils";
+
 export class KMSService {
   private encryptionContext;
 
@@ -12,6 +14,19 @@ export class KMSService {
     const buffer = Buffer.from(ciphertext, "base64");
     let kms;
 
+    const region = process.env.AWS_REGION;
+    const isGovRegion = region !== undefined && region.startsWith("us-gov-");
+    if (isGovRegion) {
+      logDebug("Govcloud region detected. Using FIPs endpoints for secrets management.");
+    }
+    let kmsClientParams = {};
+    if (isGovRegion) {
+      // Endpoints: https://docs.aws.amazon.com/general/latest/gr/kms.html
+      kmsClientParams = {
+        endpoint: `https://kms-fips.${region}.amazonaws.com`,
+      };
+    }
+
     // Explicitly try/catch this require to appease esbuild and ts compiler
     // otherwise users would need to mark this as `external`
     // see https://github.com/DataDog/datadog-lambda-js/pull/409
@@ -20,11 +35,12 @@ export class KMSService {
     } catch (err) {
       if ((err as any).code === "MODULE_NOT_FOUND") {
         // Node 18
-        return this.decryptV3(buffer);
+        return this.decryptV3(buffer, kmsClientParams);
       }
     }
     try {
-      const kmsClient = new kms();
+      // Configure KMS client to use FIPS endpoint
+      const kmsClient = new kms(kmsClientParams);
 
       // When the API key is encrypted using the AWS console, the function name is added as an encryption context.
       // When the API key is encrypted using the AWS CLI, no encryption context is added.
@@ -50,7 +66,7 @@ export class KMSService {
   }
 
   // Node 18 or AWS SDK V3
-  public async decryptV3(buffer: Buffer): Promise<string> {
+  public async decryptV3(buffer: Buffer, kmsClientParams: any): Promise<string> {
     // tslint:disable-next-line: variable-name one-variable-per-declaration
     let KMSClient, DecryptCommand;
     // Explicitly try/catch this require to appease esbuild and ts compiler
@@ -61,7 +77,8 @@ export class KMSService {
     } catch (e) {
       throw Error("Can't load AWS SDK v2 or v3 to decrypt KMS key, custom metrics may not be sent");
     }
-    const kmsClient = new KMSClient();
+
+    const kmsClient = new KMSClient(kmsClientParams);
     let result;
     try {
       const decryptCommand = new DecryptCommand({ CiphertextBlob: buffer });