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The first genome-wide association study of internet addiction; Revealed substantial shared risk factors with neurodevelopmental psychiatric disorders.

Author information

Affiliations

  • 1. Neuroimaging Genetic Laboratory, Arvin Gene Company, Tehran, Islamic Republic of Iran; Sleep Education and Research Laboratory, UCL Institute of Education, London, UK; Department of Genetics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Islamic Republic of Iran; Department of Biology, North Tehran Branch, Islamic Azad University, Tehran, Islamic Republic of Iran.
      Authors
    • Haghighatfard A 1
    (1 author)
  • 2. Neuroimaging Genetic Laboratory, Arvin Gene Company, Tehran, Islamic Republic of Iran; Vision: ScienCe First to Applications (VISTA), York University, Toronto, Canada; Department of Psychology and Hotchkiss Brain Institute, University of Calgary, Calgary, Canada.
      Authors
    • Ghaderi AH 2
    (1 author)
  • 3. Neuroimaging Genetic Laboratory, Arvin Gene Company, Tehran, Islamic Republic of Iran; Department of Genetics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Islamic Republic of Iran.
      Authors
    • Mostajabi P 3
    • Kashfi SS 3
    • Mohabati Somehsarayee H 3
    • Shahrani M 3
    • Mehrasa M 3
    (5 authors)
  • 4. Neuroimaging Genetic Laboratory, Arvin Gene Company, Tehran, Islamic Republic of Iran; Department of Genetics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Islamic Republic of Iran; Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Islamic Republic of Iran.
      Authors
    • Haghighat S 4
    (1 author)
  • 5. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Islamic Republic of Iran.
      Authors
    • Farhadi M 5
    • Momayez Sefat M 5
    • Shiryazdi AA 5
    • Ezzati N 5
    (4 authors)
    • Show all (7)

ORCIDs linked to this article

Research in Developmental Disabilities, 23 Dec 2022, 133:104393
https://doi.org/10.1016/j.ridd.2022.104393 PMID: 36566681 

Abstract 

Background

Internet addiction disorder (IAD) is listed as a disorder requiring further studies in the diagnostic and statistical manual of mental disorders (DSM-V). Psychological studies showed significant co-morbidity of IAD with depression, alcohol abuse, and anxiety disorder. Etiology and genetic bases of IAD are unclear.

Aims

Present study aimed to investigate the genetic, psychological, and cognitive bases of a tendency to internet addiction.

Methods and procedures

DNA was extracted from blood samples of IADs (N = 16,520) and 18,000 matched non-psychiatric subjects. Genotyping for the subjects was performed using SNP Array. Psychological, neuropsychological, and neurological characteristics were conducted.

Outcomes and results

Seventy-two SNPs in 24 genes have been detected significantly associated with IAD. Most of these SNPs were risk factors for psychiatric disorders. Most similarity detected with autism spectrum disorder, bipolar disorder and schizophrenia. Higher anxiety, stress, and neuroticism and deficits in working memory, attention, planning, and processing speed were detected in IADs.

Conclusions

This study is the first genome-wide association study of IAD that showed strong shared genetic bases with neurodevelopmental disabilities and psychiatric disorders.

Implications

Genetic risk factors in IADs may cause several cognitive and neurodevelopmental brain function abnormalities, which lead to excessive Internet usage. It may suggest that IAD could be a marker for vulnerability to developmental psychiatric disorders.

Full text links 

Read article at publisher's site: https://doi.org/10.1016/j.ridd.2022.104393

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Funding 

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Islamic Azad University