27/4/24, 13:51 Queratitis por herpes simple - UpToDate

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Queratitis por herpes simple

AUTOR: Alan Sugar, MD
EDITORES DE SECCIÓN: Deborah S Jacobs, MD, Martin Hirsch, MD
EDITOR ADJUNTO: Jane Givens, MD, MSCE

Todos los temas se actualizan a medida que hay nueva evidencia disponible y nuestro proceso de revisión por pares se
completa.

Revisión de la literatura vigente hasta: marzo de 2024.

Este tema se actualizó por última vez: 10 de abril de 2024.

INTRODUCCIÓN

La queratitis (infección e inflamación de la córnea) causada por el virus del herpes simple (VHS)
es una de las principales causas de ceguera en todo el mundo, debido a las cicatrices y la
opacidad de la córnea [ 1 ]. La queratitis es la forma más prevalente de enfermedad ocular por
HSV-1. Otras formas incluyen lesiones de los párpados (blefaritis herpética), conjuntivitis,
uveítis, retinitis y, raramente, escleritis [ 2 ].

Aquí se analizará el diagnóstico y el tratamiento de las infecciones corneales por HSV. La

discusión sobre la epidemiología y patogénesis de las infecciones relacionadas con el HSV-1 en
general, así como otras manifestaciones clínicas de la infección por HSV-1, se presenta por
separado. (Ver "Epidemiología, manifestaciones clínicas y diagnóstico de la infección por el virus
del herpes simple tipo 1" .)

PATOGÉNESIS

Virología del herpes simple : existen dos tipos de virus del herpes simple (VHS) clínicamente
importantes: el VHS-1 y el VHS-2. Los humanos son el único huésped natural de ambos tipos. El
HSV-1 representa la mayoría de las infecciones orales, labiales y oculares, y el HSV-2 la mayoría
de las infecciones genitales, aunque existe una superposición considerable y creciente en estas
distribuciones.

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La infección primaria por HSV-1 ocurre después de la inoculación de superficies mucosas o

cutáneas por contacto directo. Se cree que la mayoría de las enfermedades oculares por HSV
representan una reactivación del virus después del establecimiento de la latencia. La latencia se
desarrolla después de que el virus ingresa a las neuronas sensoriales y viaja a los ganglios
sensoriales (el ganglio trigémino de las enfermedades oculares) [ 3 ]. El virus permanece en los
ganglios durante toda la vida del huésped. Se ha propuesto que la latencia del HSV-1 también
puede establecerse en la córnea, aunque esto es controvertido [ 4 - 7 ]. (Consulte
"Epidemiología, manifestaciones clínicas y diagnóstico de la infección por el virus del herpes
simple tipo 1", sección sobre "Patogenia de la infección" .)

Durante la latencia, el virus no se replica y no daña las neuronas. De manera episódica, la

latencia se interrumpe y las partículas virales infecciosas viajan anterógradamente hasta las
terminaciones neuronales donde se elimina el virus. Las moléculas de ARN, conocidas como
transcripciones asociadas a la latencia, se vuelven detectables en los ganglios infectados y
desempeñan un papel en la reactivación viral [ 8 ].

Mechanisms of HSV corneal disease — The pathophysiology of HSV corneal disease is

complex and involves components of three processes: active infection, inflammation caused by
active infection, and immune reaction to past infection. Resulting structural changes in the
cornea can lead to additional forms of keratitis such as peripheral ulcerative keratitis,
neurotrophic keratopathy, and superinfection.

The cornea is the clear thin anterior refracting tissue of the eye ( figure 1). The external, tear-
covered, stratified epithelium overlies the collagenous, clear corneal stroma. The stroma
comprises the bulk of the cornea. The single cell layer endothelium, in contact with the aqueous
humor of the anterior chamber, maintains corneal clarity through fluid barrier and pump
mechanisms.

Reactivated virus enters and replicates within cells of the basal epithelium of the cornea and
spreads to adjacent cells. In primary infection, an inflammatory response triggers antigen-
specific immune responses. Immunoglobulin G (IgG) and IgA antibodies and CD4 and CD8 T
cells are involved in modulation of infection and latency [9-12]. Corneal stromal cells,
keratocytes, may support active infection with ensuing necrotizing inflammation. Retained viral
antigens may lead to subsequent immune-mediated stromal inflammation without viral
replication [13,14].

EPIDEMIOLOGY AND RISK FACTORS

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Herpes simplex virus 1 (HSV-1) infection is endemic in human populations. Most people have
been exposed by middle age, with circulating antibodies to HSV-1 detectable in 90 percent or
more of the population [1].

Primary HSV-1 infection is asymptomatic or not recognized more than 90 percent of the time
[1]. Most clinical ocular infections are manifestations of virus reactivation; ocular involvement
occurs in fewer than 5 percent of primary infections [15,16].

The majority of ophthalmic HSV cases are unilateral, with recurrences affecting the same eye.
Bilateral disease (not necessarily concurrent) occurs in 1 to 12 percent of cases and is more
common in patients with atopy or other immune abnormalities [17-19].

The incidence of ocular disease is 6.8 to 31 per 100,000 annually [20-23]. The prevalence of HSV
keratitis in the United States is about 150 per 100,000, with an estimated 20,000 new cases and
48,000 episodes annually [16,24].

Persons with HIV or other immune deficiencies are at increased risk for ocular HSV. In a
retrospective study that compared 70 patients with HSV-associated eye disease with 280
controls, persons with HIV had an increased risk of developing ocular HSV (odds ratio [OR] 3.37,
95% CI 1.09-10.40) [25].

Recurrences after an initial ocular episode have been reported in 9.6 percent at one year, 22.9
percent at two years, 40.0 percent at five years, and 67.0 percent at 10 years [19].

Risk factors for recurrence include ultraviolet laser treatment, topical ocular medications
(epinephrine, beta blockers, prostaglandins), ultraviolet light exposure, trauma, and ocular
surgery [26]. A possible association of recurrences following COVID-19 vaccination has been
suggested [27]. Immunosuppressive drugs, especially ophthalmic topical glucocorticoids, are
also a risk factor for recurrent disease.

CLINICAL MANIFESTATIONS

Symptoms — Most patients with herpes simplex virus (HSV) keratitis present with an acute
onset of symptoms including pain, visual blurring, photophobia, watery ocular discharge, and
often a red eye.

Findings by disease type — HSV keratitis has been classified in four categories: epithelial
keratitis, stromal keratitis, endotheliitis, and neurotrophic (post herpetic, meta-herpetic)
keratopathy [28,29]. Most primary ocular infection presents as epithelial keratitis, while

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subsequent ocular infection can present as recurrent epithelial keratitis, stromal keratitis, or
endotheliitis.

Primary ocular infection

Epithelial keratitis — Epithelial disease is the most frequent form of ocular HSV infection,
especially for initial episodes. Physical examination is notable for conjunctival injection near the
limbus (ciliary flush), decreased corneal sensation, and characteristic punctate or diffuse
branching (dendritic) lesions of the epithelium ( picture 1) [30]. Further findings depend on
the subtype of epithelial disease, which is further classified into dendritic keratitis, geographic
ulcerations or marginal keratitis:

● Dendritic keratitis – This is the most common initial presentation and is characterized by
dendritic lesions ( picture 1), which are classic for herpes simplex keratitis. Ocular
infection begins with granular punctate lesions that form vesicles, which rapidly coalesce
into a linear branching dendritic lesion. The lesions are caused by actively replicating virus
within epithelial cells. Dendrites may be single or multiple and vary from <1 mm to several
millimeters long. Typically, the ends of the branches of the dendrite have bulbous
thickenings. Although dendritic lesions may be somewhat visible with a hand light without
staining, slit lamp magnification and staining with dyes such as fluorescein are usually
necessary to define the details of the lesions [30,31].

● Geographic ulcers – Geographic ulcerations occur as a worsening of dendritic lesions and

are seen in up to 22 percent of cases of epithelial HSV [32]. They develop when a dendrite,
which is initially elevated, ulcerates due to lysis of the central epithelial cells. These
ulcerations may continue to have dendritic extensions at the edges [28,29]. Like dendrites,
geographic ulcers represent destruction and desquamation of epithelial cells from active
viral infection.

● Marginal keratitis – Marginal keratitis, also termed limbitis, refers to active epithelial HSV
lesions that occur at the limbus (the junctional zone of the cornea and sclera) ( figure 2)
[28]. Marginal lesions often are less dendritic in appearance than central corneal lesions
and thus may not be as easily diagnosed. The proximity to blood vessels at the limbus
allows white cell infiltration and neovascularization of the underlying corneal stroma [29].

Subsequent disease

Recurrent epithelial disease — The physical findings of recurrent epithelial disease are
similar to those on initial presentation. (See 'Epithelial keratitis' above.)

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Stromal keratitis — Stromal disease may result from an inflammatory reaction (immune
keratitis), or, less commonly, an active viral infection (necrotizing or interstitial keratitis) [13].
Stromal involvement is rarely an initial ocular finding, accounting for fewer than 2 percent of
initial presentations but for 20 to 60 percent of recurrent corneal disease [19,29,33]. Active
stromal lesions do not usually occur at the same time as epithelial disease. Stromal disease
carries a worse prognosis than epithelial keratitis. Typical physical findings depend on the type
of stromal keratitis:

● Immune keratitis – This accounts for 90 percent of recurrent stromal keratitis [33] and is
thought to represent a delayed hypersensitivity reaction to viral antigens in the cornea
[34]. Some physical examination findings include:

• A "ghost-like" superficial stromal opacity beneath the site of a previous dendrite. These
dendrite-shaped superficial lesions are clinically insignificant but may be helpful in
making the diagnosis of past HSV infection. This is usually a subtle finding only
detectable on slit lamp examination.

• Localized or diffuse inflammation of the stroma, usually without epithelial disease. The
stromal inflammatory deposits, which may look gray or white and form any shape, are
thought to represent complexes of viral antigen with antibodies and complement.
These may take the form of a ring infiltrate [34].

• Stromal neovascularization may occur. Blood vessels may grow into the normally
avascular corneal stroma, especially when the disease is longstanding. These vessels
may regress with treatment of the keratitis. Persistent vessels often leak lipids, which
opacify the cornea; this is known as lipid keratopathy [35]. Corneal stromal scarring
almost always results and may decrease vision significantly depending on location and
severity, making prompt treatment of active inflammation mandatory.

• Stromal thinning, fibrosis and vascularization beneath the epithelium (pannus), and
lipid deposits from stromal vessels are also common.

● Necrotizing keratitis – The typical physical examination finding is the presence of cellular
infiltrates within the stroma at one or more sites ( picture 2). These infiltrates may be
true abscesses and are often associated with overlying stromal ulceration. Typically, there
are white cell deposits on the corneal endothelium, keratic precipitates, and an
inflammatory reaction in the anterior chamber. Hypopyon or hyphema may result.

Corneal perforation may occur, particularly following glucocorticoid treatment without

adequate concurrent antiviral treatment ( picture 3) [8]. The severe corneal destruction

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and occasionally rapid progression may make necrotizing herpes simplex keratitis difficult
to distinguish from bacterial or fungal infection.

Endotheliitis (disciform keratitis) — Endothelial disease is uncommon but often leads to

corneal stromal edema which forms a circular (“disciform”) pattern with underlying endothelial
keratic precipitates. Rarely, a line of keratic precipitates moves slowly across the endothelium in
a pattern known as linear endotheliitis, which may be confused with cytomegalovirus keratitis
[36].

Findings are thought to be manifestations of an immune reaction rather than infection of the
endothelial cells [37]. Endotheliitis is not temporally associated with either active epithelial
infection or white blood cell infiltrative stromal disease, and triggers are unknown.

DIAGNOSIS

Herpes simplex keratitis is suspected in any patient who presents with acute onset of eye pain,
visual blurring, photophobia, and watery ocular discharge. Patients often have a red eye, but
this is not a universal finding. Presentation is usually unilateral. The diagnosis is often made on
the basis of the clinical history and examination findings without laboratory testing.

The most common presentation is that of epithelial keratitis, which has pathognomonic
dendritic lesions and may also present with geographic ulcers. The presentation of stromal
disease is more varied and the diagnosis requires an ophthalmologic examination with a slit
lamp. (See 'Findings by disease type' above.)

Certain historical features make the diagnosis more likely, including prior unilateral keratitis in
the same eye, HIV infection, a history of ultraviolet laser treatment or ultraviolet light exposure,
use of topical ocular medications (epinephrine, beta blockers, prostaglandins), or
immunosuppression. (See 'Epidemiology and risk factors' above.)

Physical findings differ based on the disease type (epithelial keratitis, stromal disease,
endotheliitis, neurotrophic keratopathy). Slit lamp examination is usually needed to confirm the
presence of typical or suspicious lesions.

Laboratory testing (ie, viral culture or herpes simplex virus [HSV] polymerase chain reaction
[PCR]) may be indicated in severe cases where the clinical findings are atypical but suspicion of
herpes simplex keratitis is high. The use of real-time PCR is increasingly available and has high
sensitivity [38]. However, even in such cases a therapeutic trial of antiviral therapy is usually
initiated. (See 'Management' below.)

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When diagnostic testing is performed, ocular samples are taken by scrapings of epithelial
lesions. Three types of tests are available: viral culture, detection of viral antigen, and detection
of viral DNA (preferred). Details of these tests are discussed elsewhere. (See "Epidemiology,
clinical manifestations, and diagnosis of herpes simplex virus type 1 infection", section on 'Tests
to confirm the diagnosis'.)

Serologic testing is generally not helpful because of the high prevalence of prior HSV exposure
in the population.

DIFFERENTIAL DIAGNOSIS

The differential diagnosis for dendritic lesions includes ophthalmic herpes zoster.
“Pseudodendrites” can also be seen with epithelial toxicity from medications or healing of
corneal abrasions. The differential diagnosis, in the absence of obvious dendritic lesions, is that
of the red eye. In recent decades Acanthamoeba keratitis has frequently been initially
misdiagnosed as HSV keratitis. (See "The red eye: Evaluation and management".)

MANAGEMENT

Ophthalmology referral — The diagnosis of epithelial herpes simplex virus (HSV) keratitis with
characteristic dendritic lesions can often be made by the primary care provider on initial
evaluation. Primary care providers can also initiate treatment for epithelial keratitis, but they
should refer the patient to an ophthalmologist within a few days for follow-up. If the initial
diagnosis is in question, or if stromal disease is suspected, a prompt ophthalmologic referral is
recommended.

Avoid topical glucocorticoid monotherapy — Primary care providers should avoid prescribing
topical glucocorticoid therapy for epithelial keratitis because applying topical glucocorticoid
drops to the infected eye (without use of concomitant antiviral medication) might lead to
involvement of deeper stromal structures with threat to vision. This has been documented in
case reports [39,40]. The use of topical glucocorticoid therapy should be reserved for the
ophthalmologist, in combination with antivirals for treatment of stromal keratitis, after
appropriate evaluation [41].

Medical treatment — The goals of treatment of HSV ocular disease are to shorten the disease
course and to prevent recurrences that can lead to corneal scarring and visual impairment.

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Epithelial keratitis — Topical antiviral therapy and oral antivirals are both effective for
treatment of dendritic and geographic herpes simplex keratitis [42-45]. The choice between oral
and topical treatment can be made based on patient preference. Oral treatments are often
preferred because of their convenience and potential to avoid corneal epithelial toxicity [44]. In
either case, a usual course of treatment is two weeks. Glucocorticoids are not recommended in
epithelial disease.

For some patients, a gentle "wiping" debridement of the corneal epithelium may be used as an
adjunct to antivirals [42,46].

Specific agents available for treatment include:

● Oral agents – Oral acyclovir (400 mg five times daily), or valacyclovir (500 mg three times
daily) are both effective. Valacyclovir has the advantage of less frequent dosing but may be
more expensive than acyclovir. Famciclovir (250 to 500 mg three times daily) may be used
for allergic patients or resistant disease. Valganciclovir, foscarnet, and cidofovir are very
rarely used because of their toxicity. Treatments can be stopped one week after healing of
the lesions.

● Topical agents – Acyclovir 3% ophthalmic ointment is the preferred topical treatment. It is

used five times daily and continued for three days after clearing of corneal lesions.

If acyclovir is not available, topical ganciclovir 0.15% gel is our preferred alternative topical
agent. It is given as one application five times daily until epithelial healing occurs and then
three times daily for one week. Ganciclovir gel appears to have less corneal toxicity than
trifluridine and may be better tolerated for long-term use [47,48].

Trifluridine 1% is given as one drop every two hours (eight or nine doses daily). Full dosing
for two weeks may be necessary to prevent early reactivation, but drops are often tapered
after the first week if there is a rapid response. Treatment is limited by epithelial toxicity,
especially when used for longer than three weeks.

Antiviral medications likely hasten the resolution of epithelial keratitis [42]. Untreated, epithelial
keratitis usually resolves in two to four weeks [19], while with antiviral treatment, healing
usually occurs in one to two weeks unless infection progresses to stromal disease [49]. A 2015
systematic review of 106 trials found that any of four topical antiviral agents (trifluridine,
acyclovir, ganciclovir, or brivudine) were equally effective and resulted in healing of 90 percent
of eyes within two weeks [42].

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Treatment with antivirals is also likely beneficial in preventing progression to stromal disease,
although clinical evidence is limited.

Geographic ulcers respond more slowly to treatment and are more likely than dendrites to lead
to scarring. Combining topical and oral antivirals does not improve the outcomes or prevent
later iritis or stromal keratitis [50].

HSV resistance to antivirals is facilitated by chronic or recurrent treatment, and the possibility of
resistance to oral antivirals should be considered in patients with recurrent HSV keratitis who do
not respond to therapy [51-53].

Stromal keratitis or endotheliitis — A combination of topical glucocorticoids and antivirals is

the standard of care for necrotizing and immune stromal keratitis [33]. Topical glucocorticoid
therapy should never be used alone, as this can cause reactivation of epithelial disease. (See
'Avoid topical glucocorticoid monotherapy' above.)

Glucocorticoids, most commonly prednisolone acetate 1% suspension, are usually given four
times daily and then tapered over several weeks depending on response. Dexamethasone 0.1%
and loteprednol 0.5% are other options. Some patients require prolonged use, over months to
years, to maintain disease suppression. Antiviral treatments are given in the same doses as for
epithelial disease, usually for the duration of glucocorticoid therapy. Oral and topical agents are
equally effective, although trifluridine is avoided due to the higher likelihood of epithelial
toxicity. (See 'Epithelial keratitis' above.)

In the Herpetic Eye Disease Study, patients with stromal keratitis were randomly assigned to
treatment with topical trifluridine 1% plus placebo or to trifluridine plus prednisolone acetate
1% administered every two hours in a tapering 10-week course [54]. The duration of
inflammation and risk of progression were significantly reduced in patients receiving
prednisolone. The rate of epithelial HSV recurrence was not increased by the topical steroids.
The addition of oral acyclovir to topical glucocorticoids and topical antivirals provided no
additional benefit [55].

The use of other antiinflammatory agents in stromal keratitis has not been well studied. Topical
cyclosporine 0.05% showed some effectiveness in several small series [56-59]. Cyclosporine 2%,
not commercially available, has similar effectiveness to topical prednisolone [60].

Endotheliitis with disciform corneal stromal edema responds well to topical glucocorticoids in
conjunction with prophylactic antivirals in controlled trials [54,61]. Linear endotheliitis appears
to be more responsive to oral antiviral agents than to topical glucocorticoids, but this has not

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been validated in controlled trials because of the infrequency of this variant [37]. Treatment is
reserved for ophthalmologists.

Expected course and follow-up — Patients treated for epithelial keratitis are usually seen one
week after initiation of treatment, at which time lesions are often healed. Treatment is then
continued for another week, at which time patients are re-evaluated.

Patients with stromal keratitis are usually also seen one week after initiation of treatment. After
that, follow-up is individualized based on severity.

Patients who have had recurrent disease are usually evaluated once a year and as needed.

Surgical treatment in select patients — Although surgical treatment is rarely warranted,

corneal transplantation may be indicated when scarring due to stromal keratitis significantly
limits vision. Rarely, endothelial keratitis may lead to permanent corneal edema, requiring
endothelial corneal transplantation.

The success rate for corneal transplantation in patients with HSV keratitis (40 percent at five
years) is lower than that in many other conditions because of a high rejection rate related to
corneal vascularization and because of recurrence of HSV keratitis [62]. Deep anterior lamellar
corneal transplantation has been recommended over full-thickness corneal transplantation
(“penetrating keratoplasty”) [63]. We administer oral acyclovir or valacyclovir to all patients
undergoing corneal transplantation for herpes simplex keratitis. This therapy is continued
indefinitely [64].

Surgical treatment of the cornea may also be necessary on an urgent basis to treat corneal
perforation [33].

Herpes simplex keratitis, even if inactive, is a relative contraindication to laser refractive surgery,
although this has been done cautiously with some success [65]. The ultraviolet light used in
excimer laser corneal refractive surgery has been associated with recurrent keratitis.

Suppression of recurrence — Recurrent ocular infections with HSV-1 are treated with the same
topical agents used for primary infections. Recurrences can lead to corneal scarring and visual
impairment in some patients. For patients with frequent or troublesome recurrences of HSV
epithelial keratitis, we suggest suppressive oral antiviral therapy with either valacyclovir or
acyclovir.

Chronic antiviral therapy reduces the frequency of recurrences in patients taking the drug, but it
is not known whether long term sequelae are reduced. Ultimately, decisions regarding chronic

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prophylactic antivirals are based on individualized assessment of recurrence frequency and

severity as well as patient preference [66].

Randomized trials indicate that recurrent infections can be prevented by daily oral suppressive
therapy [18,67-69].

● In a randomized trial, 703 patients with a history of HSV ocular disease within the
preceding year were assigned to either oral acyclovir (400 mg twice daily) or placebo for 12
months [67]. Patients assigned to the acyclovir arm had lower rates of recurrence than
patients in the placebo arm (19 versus 32 percent, rate ratio 0.55, 95% CI 0.41-0.75). The
magnitude of benefit was greatest in those with more frequent previous recurrences [18].
This effect did not persist after the drug was stopped.

● One small randomized study evaluated the efficacy of valacyclovir (one 500 mg tablet
daily) compared with acyclovir (one 400 mg tablet twice daily) in 52 immunocompetent
patients who had a history of recurrent ocular HSV disease within the past 12 months;
both suppressive regimens were found to be similarly efficacious (23 percent of patients
with recurrences in both groups) [69].

Long-term acyclovir therapy is well tolerated but has not been studied for ocular HSV. Limiting
suppressive treatment to those with more frequent episodes and the threat of vision loss may
be a cost-effective approach to management [66]. Suppressive acyclovir has been successful
and well tolerated in children and may prevent amblyopia from vision-threatening keratitis [70].
However, there is evidence that long-term oral prophylaxis may predispose to antiviral
resistance [71].

There are no vaccines approved by the US Food and Drug Administration (FDA) for HSV. Vaccines
for HSV have been studied in animal models, but they may increase the severity of immune
stromal disease [72,73]. They have not yet been successful in humans [74-77].

COMPLICATIONS AND RELATED CONDITIONS

● Herpes simplex keratouveitis – Uveitis, inflammation of the vascularized intraocular

tissues of the iris, ciliary body, and uveal tract, may occur with or without corneal
involvement by herpes simplex virus (HSV) infection. Recurrent HSV should lead the
differential diagnosis when iritis and keratitis occur together. Isolated herpes simplex iritis
may be difficult to diagnose. One feature that distinguishes uveitis due to HSV is the
tendency for involvement of the trabecular meshwork, trabeculitis, with resulting increase
in intraocular pressure. Uveitis tends to recur and is often not diagnosed as herpetic
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unless typical corneal lesions appear. Polymerase chain reaction (PCR) of aqueous humor
for HSV-1 or HSV-2 DNA can be helpful in diagnosis, although it requires an anterior
chamber paracentesis to be performed by an ophthalmologist [78].

● Post-infectious epithelial disease – Following resolution of active epithelial infection, the

corneal epithelium may be unstable. Punctate epithelial staining with fluorescein or
lissamine green dye is common. Recurrent corneal erosions and intermittent sloughing of
corneal epithelium without recurrent HSV infection may occur and may be provoked by
use of topical ocular medications, such as antivirals and preserved glaucoma drops.

● Neurotrophic keratopathy – This term refers to a condition of persistent non-healing

corneal epithelial defects associated with corneal hypoesthesia or anesthesia [49,79].
These oval defects do not represent active viral disease and are made worse by antiviral
drops. These non-healing lesions can lead to stromal scarring, corneal perforation, or
secondary bacterial infection. These lesions may be distinguished from recurrent epithelial
infection by the typical morphology on slit lamp examination and by the lack of Rose
Bengal staining at their edges.

RISK OF TRANSMISSION TO OTHERS

For patients with herpes simplex keratitis, the risk of transmitting herpes simplex virus (HSV) to
others from the infected eye is thought to be low. However, persons with HSV keratitis are likely
to also have infection elsewhere and risk of transmission from those sites should be considered.
As HSV is usually transmitted by mucosal contact, transmission of the virus would not be
expected from ocular secretions alone. However, individuals with herpes keratitis may harbor
HSV elsewhere (eg, oral secretions) and may transmit HSV from these sites. In addition,
transmission from asymptomatic donors to corneal transplant recipients has been reported
[80].

SUMMARY AND RECOMMENDATIONS

● Pathogenesis – Keratitis (corneal infection and inflammation) caused by herpes simplex

virus (HSV) is a major cause of blindness from corneal scarring and opacity worldwide.
Most ocular disease is thought to represent HSV reactivation rather than a primary ocular
infection. Corneal disease results from active infection, inflammation, and immune
reaction to past infection. (See 'Pathogenesis' above.)

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● Classification – Herpes simplex keratitis has been classified in four categories: infectious
epithelial keratitis, stromal keratitis, endotheliitis, and neurotrophic keratopathy. Epithelial
disease is most common, manifested as dendritic lesions or geographic ulcerations of the
cornea. (See 'Findings by disease type' above.)

● Diagnosis – The diagnosis of herpes simplex keratitis is largely clinical. Patients often
present with an acute onset of variable symptoms including pain, visual blurring,
photophobia, watery ocular discharge, and often a red eye. Physical examination is
notable for conjunctivitis, decreased corneal sensation, and characteristic dendritic lesions
of the cornea ( picture 1). Serologic testing is not useful. (See 'Clinical manifestations'
above and 'Diagnosis' above.)

● Subsequent disease – Stromal keratitis accounts for 20 to 60 percent of recurrent corneal

disease. Immune (non-necrotizing) keratitis usually presents as immune-mediated stromal
inflammation without concurrent epithelial disease. Necrotizing stromal keratitis is due to
active viral infection and may progress to corneal perforation. (See 'Subsequent disease'
above.)

● Management – The treatment of herpes simplex keratitis is dependent upon whether the
episode of disease is caused by active viral replication (epithelial herpes simplex keratitis)
or immune response to past infection (stromal keratitis or endotheliitis). Topical
glucocorticoids should not be used when active HSV epithelial disease is present. (See
'Management' above.)

• For patients with epithelial herpes simplex keratitis, we suggest antiviral therapy
(Grade 2C). Oral and topical antivirals are equally effective, but oral agents are more
convenient to use. Oral acyclovir (400 mg five times daily), or valacyclovir (500 mg three
times daily) can be used. Valacyclovir has the advantage of less frequent dosing but
may be more expensive than acyclovir. Treatments can be stopped one week after
healing of the lesions. (See 'Epithelial keratitis' above.)

• For patients with stromal keratitis, we suggest combination therapy with a topical
glucocorticoid and antiviral treatment (Grade 2C). Commonly used topical
glucocorticoids include prednisolone acetate 1%, dexamethasone 0.1%, and
loteprednol 0.5%. (See 'Stromal keratitis or endotheliitis' above.)

● Suppression of recurrence – We suggest that patients with frequent or troublesome

recurrences of HSV epithelial keratitis receive ongoing suppressive oral antiviral therapy
with either valacyclovir or acyclovir (Grade 2B). Valacyclovir is given 500 mg once daily and
acyclovir 400 mg twice daily. (See 'Suppression of recurrence' above.)
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● Surgical treatment – Patients who have significant vision impairment due to corneal
scarring from keratitis may require corneal transplantation. Concurrent long-term use of
oral acyclovir improves corneal graft survival. (See 'Surgical treatment in select patients'
above.)

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Tema 6896 Versión 37.0

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GRÁFICOS

Anatomía de la córnea.

Gráfico 90887 Versión 3.0

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Queratitis por herpes simple: ulceración corneal dendrítica

Úlcera corneal geográfica dendrítica característica de la queratitis por HSV. Teñido con fluoresceína y rosa
de Bengala.

VHS: virus del herpes simple.

Gráfico 69708 Versión 3.0

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Anatomía del segmento anterior del ojo.

Gráfico 62615 Versión 4.0

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Queratitis estromal por herpes simple

Gráfico 59223 Versión 3.0

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Perforación corneal en queratitis estromal por herpes simple tratada con

esteroides

Gráfico 62435 Versión 3.0

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Divulgaciones del colaborador

Alan Sugar, MD No hay relaciones financieras relevantes con empresas no elegibles para revelar.
Deborah S Jacobs, MD Consultores/Consejos asesores: Cloudbreak [Oftalmología/pterigión]; Dompé
[Oftalmología/queratitis neurotrófica]. Todas las relaciones financieras relevantes enumeradas han sido
mitigadas. Martin S Hirsch, MD No hay relaciones financieras relevantes con empresas no elegibles para
revelar. Jane Givens, MD, MSCE No hay relaciones financieras relevantes con empresas no elegibles para
revelar.

El grupo editorial revisa las divulgaciones de los contribuyentes para detectar conflictos de intereses.
Cuando se encuentran, estos se abordan mediante un proceso de revisión de varios niveles y mediante
requisitos de referencias que se deben proporcionar para respaldar el contenido. Se requiere que todos
los autores tengan contenido con las referencias adecuadas y deben cumplir con los estándares de
evidencia de UpToDate.

Política de conflicto de intereses

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