Delapril
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| Formula | C26H32N2O5 |
| Molar mass | 452.551 g·mol−1 |
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Delapril (INN, also known as alindapril) is an ACE inhibitor used as an antihypertensive drug[1] in some European and Asian countries but not in America.[2] It is taken orally, available in 15 mg and 30 mg tablets.[3]
Mechanism
[edit]Delapril is a prodrug; it is converted into two active metabolites, 5-hydroxy delapril diacid and delapril diacid. These metabolites bind completely to and inhibit angiotensin-converting enzyme (ACE), hence blocking angiotensin I to angiotensin II conversion. The resulting vasodilation prevents the vasoconstrictive effects of angiotensin II. Angiotensin II-induced aldosterone secretion by the adrenal cortex is also decreased by Delapril, leading to increases in excretion of sodium and therefore increases water outflow.[4]
References
[edit]- ^ Otero ML (2007). "Manidipine-delapril combination in the management of hypertension". Vascular Health and Risk Management. 3 (3): 255–63. PMC 2293964. PMID 17703633.
- ^ "Delapril". Drugs.com.
- ^ "Delapril". cursoenarm.net. Retrieved 2016-08-28.
- ^ "Delapril". Pubchem. U.S. National Library of Medicine. Retrieved 2016-08-28.
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